|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The genetic location on chromosome 6q, near marker D6S264 (6q25.2-q26), was also identified by the bivariate analysis as exerting significant pleiotropic influences on IRS-related phenotypes (e.g., LOD(eq) for traits-specific insulin and leptin was 4.1).
|
11283790 |
2001 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In first-degree relatives normal glucose tolerant women, fasting hyperinsulinemia, independently of the presence of metabolic syndrome, is associated with elevated IL-6 and leptin levels, suggesting an increased cardiovascular risk.
|
19685554 |
2009 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A 1SD increase in leptin and L/A ratio z-scores or a 1SD decrease in adiponectin z-score were significantly associated with higher risk of MetS.
|
28511904 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, in a metabolic syndrome animal model, the effects of leptin in ventilatory control, carotid sinus nerve activity and adenosine release by the CB are blunted.
|
29271068 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
CRP was significantly associated (P < 0.05) with multiple features of the metabolic syndrome in twins, including body mass index (BMI), blood pressure (BP), leptin and lipids.
|
17211240 |
2007 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In obese males, the rs164147 polymorphism of the NPY gene is associated with leptin, insulin level, HOMA-IR, and an increased risk of MetS and its related phenotypes, such as central obesity and hyperglycemia.
|
27788523 |
2016 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin administration to protein-restricted dams inhibits the suppression of 11beta-HSD-2 and may be one mechanism by which the metabolic syndrome is prevented.
|
15960859 |
2005 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We previously found that blood C-reactive protein (CRP), interleukin-6 (IL-6), and leptin levels were predictors of current metabolic syndrome in schizophrenia.
|
31118157 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
In MetS patients, a positive correlation was found between leptin and waist, triglycerides, and number of MetS criteria.
|
27470535 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transcription factors (AMP-activated protein kinase-1, STAT3, sterol regulatory element-binding protein-1 and peroxisome proliferator-activated receptor-γ), leptin and adiponectin receptors seem to be the most promising molecular targets for the therapy of cancers associated with MS.
|
29115033 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity.
|
16246967 |
2005 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Leptin regulates olfactory-mediated behavior in ob/ob mice.
|
16549076 |
2006 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Threshold for glucose-stimulated insulin secretion in pancreatic islets of genetically obese (ob/ob) mice is abnormally low.
|
8360782 |
1993 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No associations were detected between genetic variants of leptin-melanocortin genes and MS components.
|
23817596 |
2013 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
CTD_human |
Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men.
|
16793964 |
2006 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, this is the first study demonstrating a complex of immunochemical and immunohistochemical expression of the key adipokines including leptin, NGF and adiponectin in women with metabolic syndrome.
|
25916157 |
2014 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin, leptin and hs-CRP were significantly modified in the group with MetS (p=0.04, p=0.04, p=0.01, respectively).
|
30530892 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent studies suggest that neurotherapy comprising a single central administration of recombinant adeno-associated virus vector encoding the leptin gene severely depletes fat and ameliorates the major symptoms of metabolic syndrome for extended periods in rodents.
|
16125798 |
2005 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Leptin-deficient mice are a well characterized model for analysing the metabolic syndrome.
|
25144618 |
2014 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T. Further studies are needed to elucidate the true role of SHBG in the pathogenesis of MetS and possible mechanisms associated with serum adiponectin and leptin levels.
|
28577342 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
We selected six tagging single nucleotide polymorphisms (SNPs) representing 18 common variants in the protein tyrosine phosphatase-1B gene (PTPN1) and tested their effect on serum leptin, body fat, and measures of insulin sensitivity and the metabolic syndrome in a large sample of normal female Caucasian twins (n = 2,777; mean age, 47.4 +/- 12.5 years) from the St. Thomas' U.K.Adult Twin Registry.
|
16249458 |
2005 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Highly significant, but widely spread, h2 values were obtained for: height (0.68), weight (0.68), BMI (0.68), serum HDL (0.63), serum leptin (0.55), percentage body fat (0.53), total serum cholesterol (0.53), fasting serum insulin (0.51), homeostasis model assessment-insulin resistance index (0.48), serum TG (0.43), waist circumference (0.40), diastolic blood pressure (0.38), and 2-hour glucose level (0.17), whereas for the metabolic syndrome itself, h2 was 0.38.
|
17372303 |
2007 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our primary goal is to study the functional polymorphism (G-2548A) of the leptin (LEP) gene in the genetic predisposition of psoriasis, and our secondary goal is to examine factors affecting plasma leptin levels in psoriasis and to compare patients with and without metabolic syndrome (MS).
|
21569107 |
2011 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adipokines such as leptin and adiponectin are thought to be important, but there is new interest in other inflammatory mechanisms related to visceral obesity, insulin resistance, and the metabolic syndrome.
|
19844182 |
2010 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Results of this study indicate that leptin (15.92 ± 10.50 vs.9.43 ± 4.39 pg/ml, p < 0.001), L:A ratio (1.08 ± 1.06 vs.0.42 ± 0.38 pg/ml, p < 0.001), HOMA-IR, the lipid profile, and other metabolic risk factors (waist circumference (WC), waist-to-hip ratio(WHR), body mass index((BMI)), fasting plasma glucose (FPG) level and fasting plasma insulin(FPI)) were significantly higher but HDL, HDL/LDL and adiponectin level (20.55 ± 10.76 vs.30.08 ± 13.08 pg/ml, p < 0.001)were significantly lower in postmenopausal women with metabolic syndrome than in women without the syndrome (p < 0.001).
|
29410303 |
2018 |