|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Results of this study indicate that leptin (15.92 ± 10.50 vs.9.43 ± 4.39 pg/ml, p < 0.001), L:A ratio (1.08 ± 1.06 vs.0.42 ± 0.38 pg/ml, p < 0.001), HOMA-IR, the lipid profile, and other metabolic risk factors (waist circumference (WC), waist-to-hip ratio(WHR), body mass index((BMI)), fasting plasma glucose (FPG) level and fasting plasma insulin(FPI)) were significantly higher but HDL, HDL/LDL and adiponectin level (20.55 ± 10.76 vs.30.08 ± 13.08 pg/ml, p < 0.001)were significantly lower in postmenopausal women with metabolic syndrome than in women without the syndrome (p < 0.001).
|
29410303 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pro-inflammatory cytokines related to insulin resistance and MetS in children are tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1β, interferon gamma, pigment epithelium-derived factor, chemerin, vaspin, and fetuin A. Anti-inflammatory cytokines associated with insulin resistance and MetS in children are leptin, adiponectin, omentin, fibroblast growth factor (FGF)-21, osteocalcin, and irisin.
|
30338401 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Two SNPs in the HTR2C gene but not LEP and LEPR were associated with the presence of MS after adjustment for the combination of atypical antipsychotics.
|
29441581 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study investigated the effect of yoga on MetS people with high-normal blood pressure by exploring modulations in proinflammatory adipokines (leptin, chemerin, visfatin, and plasminogen activator inhibitor-1 or PAI-1) and an anti-inflammatory adipokine (adiponectin).
|
29205515 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
This emerging biomarker correlates with insulin resistance better than adiponectin or leptin alone, or even HOMA and is decreased with increasing number of metabolic risk factors having been proposed as a predictive marker for the MS.
|
29205099 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Leptin levels and homeostatic model assessment (HOMA) scores were significantly higher in SLE MetS<sup>+</sup> than SLE MetS<sup>-</sup> ( p = 0.018; p = 0.04).
|
29954279 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The apolipoprotein A5 Q139X, lipoprotein lipase (LPL) Hinf I, human paraoxonase 1 (PON1) 192Arg/Gln, cholesteryl ester transfer protein (CETP) Taq1B, adiponectin 45T>G and leptin (LEP) 25CAG were genotyped by real-time polymerase chain reaction in participants with and without MetS.
|
30381540 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The interactions between neurotrophins, leptin, and mast cells and the alterations in the hypothalamo-hypophyseal-adrenal axis in MetS are discussed.
|
30037593 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The relationships between RBP4 levels, the established adipokines (leptin and adiponectin) and the components of MS were examined in 3445 school-aged children recruited in 2004 for the Beijing Child and Adolescent Metabolic Syndrome study.
|
29759068 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The present results point that high leptin, resistin and ghrelin levels may be involved in the early pathophysiological process which can lead to later obesity and MeS in patients with bipolar disorder.
|
29132244 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The leptin and free leptin levels in plasma and SF were significantly higher in MetS-OA group than those in nMetS-OA group, while the adiponectin levels were lower (All p < 0.01).
|
29335849 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study aimed to compare the strength of association between MetS and leptin, adiponectin and L/A ratio, as well as to assess their performance to diagnose MetS in patients with schizophrenia.
|
29625373 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Lipodystrophy was only associated with increased macrophage infiltration (P = .04) and adiponectin messenger ribonucleic acid ([mRNA] P = .008), whereas metabolic syndrome was associated with larger adipocytes (P < .0001), decreased expression of genes related to adipogenesis and adipocyte function (P values between <.0001 and .08), increased leptin mRNA (P = .04), and a trend towards increased expression of inflammatory genes (P values between .08 and .6).
|
29788076 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The interacting effect of central obesity with all of the other four MetS risk factors increased the proinflammatory status of adipokines (TNF-α, leptin) and decreased the anti-inflammatory status of adipokine (adiponectin).
|
30114249 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Fasting plasma leptin, triglycerides, cholesterol and phospholipids are elevated, suggesting metabolic syndrome.
|
29206867 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notably, L/A outperformed individual leptin or adiponectin in discriminating a diagnosis of MS (all P < 0.02 in AUC comparisons).
|
29020116 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Patients with MetS had higher levels of leptin (14 ± 12.4) compared with those without MetS (11.2 ± 9.3 vs. 7 ± 7.1 obese and normal weight without MetS, respectively; p = .002).
|
27550773 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
A concentration of leptin > 52.18 pg/ml (AUC = 0.81, <i>p</i> < 0.0001) and resistin > 4419.27 ng/ml (AUC = 0.67, <i>p</i> = 0.049) had a good predictive value for improvement of the LVEF in the patients without MeS.
|
28721146 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Relationships of thyroid stimulating hormone (TSH) and free thyroxine (free T<sub>4</sub>) with leptin, adiponectin and the L/A ratio in euthyroid subjects were documented in 67 fasting subjects with metabolic syndrome (Mets) and 86 euthyroid subjects without MetS (TSH and free T<sub>4</sub> levels within the institutional reference range).
|
28077136 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin administration prior to tamoxifen treatment blocks development of the metabolic syndrome without affecting adipocyte loss or regeneration.
|
28065828 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Although the associations between adiponectin, leptin, resistin and metabolic abnormalities in our paediatric population were similar to those in adults, correlations of FGF21 levels with obesity, IR and MetS were the inverse of those found in adults.
|
28139438 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A 1SD increase in leptin and L/A ratio z-scores or a 1SD decrease in adiponectin z-score were significantly associated with higher risk of MetS.
|
28511904 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
In MetS patients, a positive correlation was found between leptin and waist, triglycerides, and number of MetS criteria.
|
27470535 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T. Further studies are needed to elucidate the true role of SHBG in the pathogenesis of MetS and possible mechanisms associated with serum adiponectin and leptin levels.
|
28577342 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study evaluated some probable predictors of metabolic syndrome (MS), such as leptin and adiponectin concentrations, the leptin/adiponectin ratio, insulin resistance, and adiposity, in a sample of child survivors of lymphoma and leukemia in Mexico City.
|
28193268 |
2017 |