|
Peritoneal Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, miR-145 promotes the EMT during the development of peritoneal fibrosis by suppressing FGF10 activity, suggesting that miR-145 represents a potential therapeutic target for managing peritoneal fibrosis.
|
31431501 |
2019 |
|
Carcinoma of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer decreased, the higher the expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer were, the better the prognosis was. miRNA-145 and miRNA-218 were used as indicators of assessing the prognosis of patients with laryngeal cancer.
|
31289552 |
2019 |
|
Middle Cerebral Artery Occlusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
It is downregulated in peripheral blood mononuclear cells of MS patients; nonetheless, its role in MS has not been fully clear. miR-145-5p known as a putative regulator of NR4A2 and in a middle cerebral artery occlusion/reperfusion model, anti-miR-145-5p administration promoted neurological outcomes in rat.
|
30684217 |
2019 |
|
early pregnancy
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of miR-145 was found to be downregulated during the decidualization period of early pregnancy and also in artificially induced decidualization in rat uterus.
|
30729278 |
2019 |
|
Facial Neuritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Besides, miR-145/Bnip3/mitophagy axis may be considered as a potential target for the treatment of facial neuritis in clinical practice.
|
30551550 |
2019 |
|
Hypospadias
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of microarray indicated miR-145 as a differentially expressed biomarker between hypospadias tissues and normal tissues (p < 0.05).
|
30565690 |
2019 |
|
skin damage
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
It was found that the miR-155 has a certain diagnostic value in arsenic-induced skin damage (AUC = 0.83), miR-21 and miR-145 have diagnostic value for liver damage (AUC = 0.80, 0.81) and miR-191 has diagnostic value for kidney damage (AUC = 0.83).
|
31085440 |
2019 |
|
Drug Resistant Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We suggested that decreased expression of miRNA-145-5p could be a potential non-invasive biomarker for early detection and clinical evaluation of refractory epilepsy.
|
31022636 |
2019 |
|
Myxoid cyst
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study is to investigate the role of miR-145-5p in high glucose-induced RGC injury.
|
31272285 |
2019 |
|
Vascular lesions
|
0.010 |
Biomarker
|
disease |
BEFREE |
MicroRNA-145 Involves in the Pathogenesis of Renal Vascular Lesions and May Become a Potential Therapeutic Target in Patients with Juvenile Lupus Nephritis.
|
31430759 |
2019 |
|
Tumor Angiogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Collectively, DANCR plays a promotional role in tumor angiogenesis in ovarian cancer through regulation of miR-145/VEGF axis.
|
31545000 |
2019 |
|
Penile hypospadias
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of microarray indicated miR-145 as a differentially expressed biomarker between hypospadias tissues and normal tissues (p < 0.05).
|
30565690 |
2019 |
|
NUT midline carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484.
|
29322795 |
2019 |
|
Luminal A Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ROC curve and AUC analysis of the data found that the combination of three miRNAs (miR-145, miR-195 and miR-486) had the best diagnostic value for luminal A breast cancer with an AUC of 0.875, with 76% sensitivity and 81% specificity.
|
30840191 |
2019 |
|
Inflammatory dermatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that miR-145-5p negatively regulates proliferation and chemokine secretion of NHEKs by targeting MLK3, and downregulation of miR-145-5p contributes to skin inflammation in psoriasis lesions.
|
30269330 |
2019 |
|
Complete Trisomy 21 Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
An integrated analysis of miR and mRNA expression in the thymus in Down syndrome is reported in the present study. miR‑30c, miR‑145, miR‑183 and their targets may serve important roles in the pathogenesis and development of complications in Down syndrome.
|
31257513 |
2019 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-145-5p Increases Osteoclast Numbers In Vitro and Aggravates Bone Erosion in Collagen-Induced Arthritis by Targeting Osteoprotegerin.
|
30059491 |
2018 |
|
Carotid Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-145 is critical for modulation of vascular smooth muscle cell proliferation in human carotid artery stenosis.
|
29921375 |
2018 |
|
Cystic Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-145 is increased fourfold in CF BAL fluid compared with non-CF (P < 0.01) and increased 10-fold in CF primary airway epithelial cells (P < 0.01).
|
29232160 |
2018 |
|
Hyperglycemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sustained high glucose concentration (hyperglycaemia) significantly decreased miR-145 expression in cardiomyocytes.
|
29178342 |
2018 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
MiR-145 might be one of the candidates for anti-inflammatory treatment for metabolic diseases.
|
29388044 |
2018 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
MiR-145 can mollify neuropathic pain in a chronic constriction injury rat model by reducing inflammation and ion channel overexpression through Akt3/mTOR and Akt3/NF-κB signaling pathways.
|
29162479 |
2018 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis showed that participants with anxiety, high body mass index, abdominal obesity and family history of hypertension had higher risk for EH, whereas those with bland diet and occupational physical activities had lower risk for EH. qPCR assays showed that NR_027032 (P = 0.015) and NR_034083 (P = 0.004) were significantly reduced in EH patients compared with controls, whereas NR_104181 (P = 0.007), miR-143 (P = 0.005) and miR-145 (P = 0.015) were significantly elevated.
|
29609545 |
2018 |
|
Androgen-Insensitivity Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Microarray analysis identified miRNA-145-5p (miR-145) as a potential upstream regulator. miR-145 and β-catenin mRNA ( CTNNB1) were overexpressed in AIS bone tissues and primary osteoblasts, and their expression correlated positively in AIS.
|
29906249 |
2018 |
|
Urinary tract infection
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Most importantly, miR-145-5p expression in IFTA patients was significantly downregulated and displayed a high diagnostic accuracy compared to SGF alone (AUC = 0.891) and compared to SGF, UTI, BL, TCMR and ABMR patients combined (AUC = 0.835), which was verified by cross-validation.
|
30102719 |
2018 |