|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
It was predominantly found in MLL-rearranged AML (13/47), monosomy 7 (2/3), or FAB M6/7 (6/10), and mutually exclusive with core-binding factor AML, t(15;17), and NPM1 mutations.
|
20357826 |
2010 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving the mixed lineage leukemia (MLL) gene, localized at 11q23, frequently occur in pediatric acute myeloid leukemia (AML).
|
20861917 |
2010 |
|
Acute monocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Segmental amplification of MLL gene associated with high expression of AURKA and AURKB genes in a case of acute monoblastic leukemia with complex karyotype.
|
20303016 |
2010 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ras activation seems to complement the MLLT3-MLL oncogene in transformation with features of de novo and t-AML with MLLT3-MLL being similar.
|
20395514 |
2010 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We retrospectively collected outcome data of 756 children with 11q23- or MLL-rearranged AML from 11 collaborative groups to identify differences in outcome based on translocation partners.
|
19528532 |
2009 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A bone marrow examination confirmed the diagnosis of acute monocytic leukemia with a t(11;19) MLL-ELL fusion transcript.
|
19405140 |
2009 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A novel AF9 breakpoint in MLL-AF9-positive acute monoblastic leukemia.
|
18000862 |
2008 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
RT-PCR and sequencing revealed that exon 7 of MLL was fused to exon 2 of MAML2 in the AML and MDS cells.
|
17551948 |
2007 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report a t(4;11)(p12;q23) with rearrangement of MLL and FRYL (also known as AF4p12), a human homolog to the furry gene of Drosophila, in an adult patient with therapy-related AML after fludarabine and rituximab therapy for small lymphocytic lymphoma and radiation therapy for breast carcinoma.
|
17854671 |
2007 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results confirm recent reports of perturbed HOX expression in NPM1-mutated adult AML, and provide the first evidence that the NPM1-mutated signature is distinct from MLL-rearranged AML.
|
17597811 |
2007 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML.
|
16956839 |
2006 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have identified a new mixed lineage leukemia (MLL) gene fusion partner in a patient with treatment-related acute myeloid leukemia (AML) presenting a t(2;11)(q37;q23) as the only cytogenetic abnormality.
|
16682951 |
2006 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL fusion genes are a predominant feature of acute leukemias in infants and in secondary acute myeloid leukemia (AML) associated with prior chemotherapy with topo-II poisons.
|
16688745 |
2006 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that the leukemic cells of AML patients with MLL gene rearrangements express low to undetectable amounts of SPARC whereas normal hematopoietic progenitors and most AML patients express this gene.
|
16424866 |
2006 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation.
|
15621793 |
2005 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MYO1F, unconventional myosin type 1F, gene is fused to MLL in infant acute monocytic leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22.
|
15897884 |
2005 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
For the vegetable and fruit index, there were significant or near-significant inverse linear trends for all leukemias combined, ALL(MLL+), and AML(MLL-).
|
15767345 |
2005 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the MLL (11q23) gene in AML are usually related to the morphological phenotype FAB M5.
|
16044313 |
2005 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On the molecular level, no differences in FLT3 expression levels were detected between AML with and without any FLT3 mutation as well as for FAB M5 with or without MLL abnormalities (p=0.495).
|
16330434 |
2005 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity.
|
15262427 |
2004 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a second case--an infant acute monocytic leukemia (AML M5b)--with an MLL/GRAF fusion.
|
15382263 |
2004 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases.
|
12805060 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MLL/SEPTIN6 chimeric transcript from inv ins(X;11)(q24;q23q13) in acute monocytic leukemia: report of a case and review of the literature.
|
12874781 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides.
|
12619163 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Karyotyping detected abnormal chromosome 11 only in 4/43 patients and Classical t(4:11) in one AML patient but combination of Painting FISH and LS-FISH confirmed ALL-1 gene alteration in 17/18 cases.
|
12860012 |
2003 |