|
Nonorganic psychosis
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Gadd45b is abnormally expressed in subjects with autism and psychosis, two disorders associated with cognitive deficits.
|
22802593 |
2012 |
|
Nonorganic psychosis
|
0.310 |
Biomarker
|
disease |
BEFREE |
On the basis of these results, we conclude that GADD45b may be increased in psychosis compensatory to its inability to access gene promoter regions.
|
22048458 |
2012 |
|
Nonorganic psychosis
|
0.310 |
Biomarker
|
disease |
PSYGENET |
On the basis of these results, we conclude that GADD45b may be increased in psychosis compensatory to its inability to access gene promoter regions.
|
22048458 |
2012 |
|
Arsenic Poisoning, Inorganic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Nervous System, Organic Arsenic Poisoning
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Arsenic Poisoning
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Arsenic Encephalopathy
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Arsenic Induced Polyneuropathy
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of GADD45beta has been verified to be specific in hepatocellular cancer (HCC) and consistent with the p53 mutant, and degree of malignancy of HCC.
|
15509538 |
2004 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Subsequently, lncRNA FENDRR and GADD45B were revealed to have poor expressions in HCC.
|
31351327 |
2019 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
LHGDN |
Moreover, we found that expression of GADD45beta was inversely correlated to the presence of mutant p53 in HCC tissue (P < 0.05).
|
12759252 |
2003 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The growth-arrest DNA damage inducible gene 45beta (Gadd45beta) has been reported as a potential diagnostic marker for aggressive hepatocellular carcinoma.
|
18225533 |
2008 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of GADD45beta, which is known to influence cell growth control, apoptosis, and cellular response to DNA damage, has been verified to be specific in hepatocellular carcinoma and consistent with the degree of malignancy.
|
17591973 |
2007 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of Gadd45beta in HCC cell lines also induces drug resistance against 5-FU.
|
17711513 |
2007 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Thus, these data reveal nuclear receptor CAR interacts with GADD45B to repress p38 MAPK signaling and elicit hepatocyte proliferation in male mice.<b>Implications:</b> This GADD45B-regulated male-predominant proliferation can be expanded as a phenobarbital promotion signal of HCC development in future studies.<b>Visual Overview:</b> http://mcr.aacrjournals.org/content/molcanres/16/8/1309/F1.large.jpg <i></i>.
|
29716964 |
2018 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells.
|
21062976 |
2010 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
An increase in P21 expression as a consequence of downregulation of Snail accompanied by the induction of GADD45B expression is the main mechanism leading to cell cycle arrest in HCCs.
|
27134688 |
2016 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we found that expression of GADD45beta was inversely correlated to the presence of mutant p53 in HCC tissue (P < 0.05).
|
12759252 |
2003 |
|
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
GADD45B (induced by TNFα in monocytes) and PDE4D (induced by TNFα in FLS) immunostaining was significantly higher in overall poor-responders to therapy in 46 independent baseline samples obtained from early untreated RA patients prior to initiation of therapy.
|
26792343 |
2016 |
|
Rheumatoid Arthritis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The odds ratio of GADD45b genotype -712CT (rs3795024) in DR4-negative RA patients was 0.41 (95% CI, 0.18-0.95).
|
31195707 |
2019 |
|
Rheumatoid Arthritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Deficient Gadd45beta expression in RA can contribute to activation of JNK, exacerbate clinical arthritis, and augment joint destruction.
|
19877043 |
2009 |
|
Malignant tumor of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here we showed that in the SW620 human colon cancer cell line, TSA and butyrate induced the growth arrest and DNA damage gene 45alpha (GADD45alpha) and GADD45beta.
|
12406558 |
2002 |
|
Malignant tumor of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
In further studies of multiple human cancer tissues, GADD45beta strongly stained tissues such as colon cancer, breast cancer, prostate cancer, squamous cell cancer, lymphoma, and leiomyosarcoma, suggesting that the decreased expression of GADD45beta is specific to HCC.
|
12759252 |
2003 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In further studies of multiple human cancer tissues, GADD45beta strongly stained tissues such as colon cancer, breast cancer, prostate cancer, squamous cell cancer, lymphoma, and leiomyosarcoma, suggesting that the decreased expression of GADD45beta is specific to HCC.
|
12759252 |
2003 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here we showed that in the SW620 human colon cancer cell line, TSA and butyrate induced the growth arrest and DNA damage gene 45alpha (GADD45alpha) and GADD45beta.
|
12406558 |
2002 |