|
Kaposi Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target GADD45B To Protect Infected Cells from Cell Cycle Arrest and Apoptosis.
|
27852859 |
2017 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GADD45beta was expressed at higher levels in cartilage from normal donors and patients with early OA than in cartilage from patients with late-stage OA.
|
18576389 |
2008 |
|
Synovitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling.
|
19877043 |
2009 |
|
Psychotic Disorders
|
0.310 |
Biomarker
|
group |
PSYGENET |
Gadd45b is abnormally expressed in subjects with autism and psychosis, two disorders associated with cognitive deficits.
|
22802593 |
2012 |
|
Nonorganic psychosis
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Gadd45b is abnormally expressed in subjects with autism and psychosis, two disorders associated with cognitive deficits.
|
22802593 |
2012 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
GADD45B, a tumor suppressor gene potentially through the p53-mediated apoptotic pathways, is paradoxically overexpressed in CRC and as such may play an unappreciated role in tumorigenesis.
|
23110778 |
2012 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
GADD45B, a tumor suppressor gene potentially through the p53-mediated apoptotic pathways, is paradoxically overexpressed in CRC and as such may play an unappreciated role in tumorigenesis.
|
23110778 |
2012 |
|
Giant Cell Arteritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GADD45B expression was not correlated with GCA patients survival, while GADD45A and GADD45G methylation status and protein expression were independently associated with GCA patients' survival.
|
23616123 |
2013 |
|
Rheumatoid Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
GADD45B (induced by TNFα in monocytes) and PDE4D (induced by TNFα in FLS) immunostaining was significantly higher in overall poor-responders to therapy in 46 independent baseline samples obtained from early untreated RA patients prior to initiation of therapy.
|
26792343 |
2016 |
|
Refractory anemias
|
0.010 |
Biomarker
|
disease |
BEFREE |
GADD45B (induced by TNFα in monocytes) and PDE4D (induced by TNFα in FLS) immunostaining was significantly higher in overall poor-responders to therapy in 46 independent baseline samples obtained from early untreated RA patients prior to initiation of therapy.
|
26792343 |
2016 |
|
Stage II Colorectal Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
GADD45B as a Prognostic and Predictive Biomarker in Stage II Colorectal Cancer.
|
30029519 |
2018 |
|
Stage II Colorectal Cancer AJCC v7
|
0.010 |
Biomarker
|
disease |
BEFREE |
GADD45B as a Prognostic and Predictive Biomarker in Stage II Colorectal Cancer.
|
30029519 |
2018 |
|
Germ Cell Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment.
|
27572311 |
2016 |
|
Adrenoleukodystrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
All 4 agents down-regulated the expression of Gadd45b in the presence of ethanol, which could explain the mechanism of DNA demethylation associated with the up-regulation of the gene expression observed in experimental ALD.
|
21352821 |
2011 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Among the nine genes, we focused on growth arrest and DNA-damage-inducible beta (GADD45B) and phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) as representative TFAP2C-regulated tumor suppressor genes.
|
31296259 |
2019 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
An increase in P21 expression as a consequence of downregulation of Snail accompanied by the induction of GADD45B expression is the main mechanism leading to cell cycle arrest in HCCs.
|
27134688 |
2016 |
|
Myeloid Leukemia, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
BCR-ABL Gadd45b deficient CML progenitors exhibited increased proliferation and decreased apoptosis, associated with hyper-activation of c-Jun NH<sub>2</sub>-terminal kinase and Stat5.
|
30279966 |
2018 |
|
Primary Myelofibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BM from PMF expressed a noncanonical transforming growth factor β (TGF-β) signature, which included activation of ID1, JUN, GADD45b, and genes with binding motifs for the JUN transcriptional complex AP1.
|
31678370 |
2019 |
|
essential thrombocytopenia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By contrast, the expression of ID1 and GADD45b was not altered and there was a modest signal for JUN activation in ET.
|
31678370 |
2019 |
|
Rheumatoid Arthritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Deficient Gadd45beta expression in RA can contribute to activation of JNK, exacerbate clinical arthritis, and augment joint destruction.
|
19877043 |
2009 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of GADD45beta has been verified to be specific in hepatocellular cancer (HCC) and consistent with the p53 mutant, and degree of malignancy of HCC.
|
15509538 |
2004 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of GADD45beta has been verified to be specific in hepatocellular cancer (HCC) and consistent with the p53 mutant, and degree of malignancy of HCC.
|
15509538 |
2004 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of GADD45beta has been verified to be specific in hepatocellular cancer (HCC) and consistent with the p53 mutant, and degree of malignancy of HCC.
|
15509538 |
2004 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of GADD45beta, which is known to influence cell growth control, apoptosis, and cellular response to DNA damage, has been verified to be specific in hepatocellular carcinoma and consistent with the degree of malignancy.
|
17591973 |
2007 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of GADD45beta, which is known to influence cell growth control, apoptosis, and cellular response to DNA damage, has been verified to be specific in hepatocellular carcinoma and consistent with the degree of malignancy.
|
17591973 |
2007 |