|
Primary Myelofibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BM from PMF expressed a noncanonical transforming growth factor β (TGF-β) signature, which included activation of ID1, JUN, GADD45b, and genes with binding motifs for the JUN transcriptional complex AP1.
|
31678370 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study indicates that GADD45B and PMAIP1 could be promising tumor suppressors for NSCLC and might be useful as prognostic markers for use in NSCLC therapy.
|
31296259 |
2019 |
|
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggested that the ALK5 signaling pathway plays a critical role in mediating neural plasticity and neurological function recovery via Gadd45b after cerebral ischemia, representing a new potential target for cerebral I/R injury.
|
31043581 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In clinical manifestation, the odds ratio of GADD45b -712CT genotype with anti-RNP antibody was 4.14 (95% CI, 1.10-15.63) in SLE patients.
|
31195707 |
2019 |
|
Premature Menopause
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, MB-MSCs combined with BSTCR rescued epirubicin induced POF through down-regulating GADD45b and pCDC2 expressions, and up-regulating CyclinB1 and CDC2 expressions.
|
31311554 |
2019 |
|
Progeria
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of progerin production in cells of aged non-HGPS donors <i>in vivo</i> increases the proliferative activity, H3K9me3, and HP1, and decreases the senescence markers p21, IGFBP3, and GADD45B to the levels of young donor cells.
|
31156709 |
2019 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
In our previous studies, growth arrest and DNA damage protein 45b (Gadd45b) mediated axonal plasticity after stroke.
|
31043581 |
2019 |
|
Thymoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Real-time PCR analysis confirmed that CCL25 was upregulated; and MYC, GADD45B, TNFRSF12 downregulated in thymoma with MG. Our study thus provided important genetic information on thymoma.
|
30787364 |
2019 |
|
Ovarian Failure, Premature
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, MB-MSCs combined with BSTCR rescued epirubicin induced POF through down-regulating GADD45b and pCDC2 expressions, and up-regulating CyclinB1 and CDC2 expressions.
|
31311554 |
2019 |
|
essential thrombocytopenia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By contrast, the expression of ID1 and GADD45b was not altered and there was a modest signal for JUN activation in ET.
|
31678370 |
2019 |
|
social stress
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, these data suggest that Gadd45b in NAc contributes to susceptibility to social stress.
|
30874581 |
2019 |
|
Myeloid Leukemia, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
BCR-ABL Gadd45b deficient CML progenitors exhibited increased proliferation and decreased apoptosis, associated with hyper-activation of c-Jun NH<sub>2</sub>-terminal kinase and Stat5.
|
30279966 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The immunohistochemical analysis of Gadd45β expression revealed that 75% of histological specimens from patients with CCA expressed high levels of Gadd45β, and that high Gadd45β expression was associated with metastasis.
|
29435034 |
2018 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of Gadd45β in CCA was examined using siRNA-mediated gene knockdown in HuCCA-1, a human CCA cell line established from a Thai patient.
|
29435034 |
2018 |
|
Congenital contractural arachnodactyly
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of Gadd45β in CCA was examined using siRNA-mediated gene knockdown in HuCCA-1, a human CCA cell line established from a Thai patient.
|
29435034 |
2018 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Matrine may be used to treat prostate cancer patients to increase the levels of GADD45B to inhibit tumor invasion and improve patient survivals.
|
29356020 |
2018 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Matrine may be used to treat prostate cancer patients to increase the levels of GADD45B to inhibit tumor invasion and improve patient survivals.
|
29356020 |
2018 |
|
Stage II Colorectal Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
GADD45B as a Prognostic and Predictive Biomarker in Stage II Colorectal Cancer.
|
30029519 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Matrine may be used to treat prostate cancer patients to increase the levels of GADD45B to inhibit tumor invasion and improve patient survivals.
|
29356020 |
2018 |
|
Progression of prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B.
|
29356020 |
2018 |
|
Stage II Colorectal Cancer AJCC v7
|
0.010 |
Biomarker
|
disease |
BEFREE |
GADD45B as a Prognostic and Predictive Biomarker in Stage II Colorectal Cancer.
|
30029519 |
2018 |
|
Kaposi Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target GADD45B To Protect Infected Cells from Cell Cycle Arrest and Apoptosis.
|
27852859 |
2017 |
|
Malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MDR (multifactor dimensionality reduction) analyses showed that smoking history as main effect and three-way models (smoking duration, 19p13.3-GADD45B rs3783501, 19q13.3-CD3EAP rs967591) (P = 0.001-0.002) indicated statistically significant association with lung cancer risk.
|
28870783 |
2017 |
|
Social Anxiety
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this context, we investigated the effects of chronic social defeat stress (CSDS) on anxiety-, social- and cognitive-related behaviors, as well as hippocampal Bdnf, synaptic plasticity markers (PSD-95, Synaptophysin, Spinophilin, Synapsin I and MAP-2), and epigenetic modifying enzymes (MYST2, HDAC2, HDAC6, MLL3, KDM5B, DNMT3B, GADD45B) gene expression in C57BL/6J mice.
|
28374847 |
2017 |
|
Carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MDR (multifactor dimensionality reduction) analyses showed that smoking history as main effect and three-way models (smoking duration, 19p13.3-GADD45B rs3783501, 19q13.3-CD3EAP rs967591) (P = 0.001-0.002) indicated statistically significant association with lung cancer risk.
|
28870783 |
2017 |