|
Psychotic Disorders
|
0.310 |
Biomarker
|
group |
BEFREE |
On the basis of these results, we conclude that GADD45b may be increased in psychosis compensatory to its inability to access gene promoter regions.
|
22048458 |
2012 |
|
Nonorganic psychosis
|
0.310 |
Biomarker
|
disease |
BEFREE |
On the basis of these results, we conclude that GADD45b may be increased in psychosis compensatory to its inability to access gene promoter regions.
|
22048458 |
2012 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of GADD45beta has been verified to be specific in hepatocellular cancer (HCC) and consistent with the p53 mutant, and degree of malignancy of HCC.
|
15509538 |
2004 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Subsequently, lncRNA FENDRR and GADD45B were revealed to have poor expressions in HCC.
|
31351327 |
2019 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The growth-arrest DNA damage inducible gene 45beta (Gadd45beta) has been reported as a potential diagnostic marker for aggressive hepatocellular carcinoma.
|
18225533 |
2008 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of GADD45beta, which is known to influence cell growth control, apoptosis, and cellular response to DNA damage, has been verified to be specific in hepatocellular carcinoma and consistent with the degree of malignancy.
|
17591973 |
2007 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of Gadd45beta in HCC cell lines also induces drug resistance against 5-FU.
|
17711513 |
2007 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Thus, these data reveal nuclear receptor CAR interacts with GADD45B to repress p38 MAPK signaling and elicit hepatocyte proliferation in male mice.<b>Implications:</b> This GADD45B-regulated male-predominant proliferation can be expanded as a phenobarbital promotion signal of HCC development in future studies.<b>Visual Overview:</b> http://mcr.aacrjournals.org/content/molcanres/16/8/1309/F1.large.jpg <i></i>.
|
29716964 |
2018 |
|
Liver carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells.
|
21062976 |
2010 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
An increase in P21 expression as a consequence of downregulation of Snail accompanied by the induction of GADD45B expression is the main mechanism leading to cell cycle arrest in HCCs.
|
27134688 |
2016 |
|
Liver carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we found that expression of GADD45beta was inversely correlated to the presence of mutant p53 in HCC tissue (P < 0.05).
|
12759252 |
2003 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
GADD45B, a tumor suppressor gene potentially through the p53-mediated apoptotic pathways, is paradoxically overexpressed in CRC and as such may play an unappreciated role in tumorigenesis.
|
23110778 |
2012 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The 19p13.3-GADD45B encoded protein product is involved in apoptosis and inhibiting tumor growth.
|
28870783 |
2017 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Among the nine genes, we focused on growth arrest and DNA-damage-inducible beta (GADD45B) and phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) as representative TFAP2C-regulated tumor suppressor genes.
|
31296259 |
2019 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Matrine promoted the expression of GADD45B, a tumor suppressive gene that is involved in the regulation of cell cycle, DNA damage repair, cell survival, aging, apoptosis and other cellular processes through p38/JNK, ROS-GADD45B-p38, or other signal pathways.
|
29356020 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors.
|
21810943 |
2011 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)].
|
24190252 |
2014 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of GADD45beta, which is known to influence cell growth control, apoptosis, and cellular response to DNA damage, has been verified to be specific in hepatocellular carcinoma and consistent with the degree of malignancy.
|
17591973 |
2007 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
For example, we found that the different genotypes of SNP GADD45B E1122 are all associated with cancer risk.
|
16026601 |
2005 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Importantly, this study also provides the groundwork to further examine the regulation of gadd45b expression in in vivo settings using animal models and tissues obtained from normal individuals and cancer patients prior to and after chemotherapeutic intervention.
|
19834918 |
2009 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of GADD45beta has been verified to be specific in hepatocellular cancer (HCC) and consistent with the p53 mutant, and degree of malignancy of HCC.
|
15509538 |
2004 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of GADD45beta, which is known to influence cell growth control, apoptosis, and cellular response to DNA damage, has been verified to be specific in hepatocellular carcinoma and consistent with the degree of malignancy.
|
17591973 |
2007 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
For example, we found that the different genotypes of SNP GADD45B E1122 are all associated with cancer risk.
|
16026601 |
2005 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Importantly, this study also provides the groundwork to further examine the regulation of gadd45b expression in in vivo settings using animal models and tissues obtained from normal individuals and cancer patients prior to and after chemotherapeutic intervention.
|
19834918 |
2009 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Down-regulation of GADD45beta has been verified to be specific in hepatocellular cancer (HCC) and consistent with the p53 mutant, and degree of malignancy of HCC.
|
15509538 |
2004 |