GAL, galanin and GMAP prepropeptide, 51083

N. diseases: 226; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4225318
Disease: EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
EPILEPSY, FAMILIAL TEMPORAL LOBE, 8 		0.600 GeneticVariation disease UNIPROT Galanin pathogenic mutations in temporal lobe epilepsy. 25691535 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 GeneticVariation disease BEFREE In conclusion, the SNP rs948854 in the GAL gene seems to be involved in the modulation of depressive state, especially in individuals with GG genotype. 28987550 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 GeneticVariation disease BEFREE The findings clearly indicate that the GAL gene polymorphism is closely correlated to the incidence of depression in the Chinese Han female patients. 23741354 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE The findings clearly indicate that the GAL gene polymorphism is closely correlated to the incidence of depression in the Chinese Han female patients. 23741354 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). 21042317 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 GeneticVariation disease BEFREE The aim of our study was, for the first time, to identify GAL haplotypes and investigate associations with alcoholism and anxiety. 16314872 2006
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.330 GeneticVariation disease BEFREE Reward-related ventral striatum reactivity mediates gender-specific effects of a galanin remote enhancer haplotype on problem drinking. 23489876 2013
CUI: C0019569
Disease: Hirschsprung Disease
Hirschsprung Disease 		0.320 GeneticVariation disease BEFREE Our study for the first time indicates that genetic variants within GAL, GAP43 and NRSN1 and related gene-gene interaction networks might be involved in the altered susceptibility to HSCR in the Han Chinese population, which might shed more light on HSCR pathogenesis. 29654647 2018
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.310 GeneticVariation disease BEFREE Initial findings showed a positive relationship of cannabis usage (OR = 2.070, P = 0.007, N = 406 (individuals who had used cannabis at least once within the last 12 months, total sample size 2731) with the GG haplotype, consistent with the previous published data linking galanin with an increased release of dopamine. 25228436 2014
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.210 GeneticVariation disease BEFREE Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses. 10982176 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 GeneticVariation group BEFREE GALN is located at chromosome 11q13, a frequently amplified locus in diverse tumor types including breast cancer. 9537228 1998
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 GeneticVariation phenotype BEFREE The findings clearly indicate that the GAL gene polymorphism is closely correlated to the incidence of depression in the Chinese Han female patients. 23741354 2013
CUI: C0003467
Disease: Anxiety
Anxiety 		0.090 GeneticVariation disease BEFREE A role of galanin in depression is also supported by a recent candidate gene study, showing that variants in genes for galanin and its three receptors confer increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. 30627087 2018
CUI: C0003467
Disease: Anxiety
Anxiety 		0.090 GeneticVariation disease BEFREE Here we report that variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events in a European white population cohort totaling 2,361 from Manchester, United Kingdom and Budapest, Hungary. 24706871 2014
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.090 GeneticVariation group BEFREE Here we report that variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events in a European white population cohort totaling 2,361 from Manchester, United Kingdom and Budapest, Hungary. 24706871 2014
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.090 GeneticVariation group BEFREE A role of galanin in depression is also supported by a recent candidate gene study, showing that variants in genes for galanin and its three receptors confer increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. 30627087 2018
CUI: C0002986
Disease: Fabry Disease
Fabry Disease 		0.070 GeneticVariation disease BEFREE Previously, we have reported the structure of human alpha-GAL, which revealed the overall structure of the enzyme and established the locations of hundreds of mutations that lead to the development of Fabry disease. 19940122 2010
CUI: C0002986
Disease: Fabry Disease
Fabry Disease 		0.070 GeneticVariation disease BEFREE Examining the frequency of mutation around each alpha-GAL residue identifies the active site as a hotspot for mutations leading to Fabry disease. 12359124 2003
CUI: C0002986
Disease: Fabry Disease
Fabry Disease 		0.070 GeneticVariation disease BEFREE We hypothesize that the three new mutations affect the GAL-A protein, leading to conformational FD. 19941952 2010
CUI: C0028754
Disease: Obesity
Obesity 		0.060 GeneticVariation disease BEFREE In addition, we performed a pedigree transmission disequilibrium test (PDT) for one SNP (GAL: g.-244G-->A) in 610 (518 independent) obesity-trios (obese child or adolescent and both of its parents). 15930442 2005
CUI: C0016952
Disease: Galactosemias
Galactosemias 		0.050 GeneticVariation disease BEFREE The development of POF in females with galactosemia is more likely if the patient's genotype is Q188R/Q188R, if the mean erythrocyte Gal-1-P is >3.5 mg/dL during therapy, and if the recovery of (13)CO(2) from whole-body (13)C-galactose oxidation is reduced below 5% of administered (13)C-galactose. 11113841 2000
CUI: C0268151
Disease: Classical galactosemia
Classical galactosemia 		0.050 GeneticVariation disease BEFREE The development of POF in females with galactosemia is more likely if the patient's genotype is Q188R/Q188R, if the mean erythrocyte Gal-1-P is >3.5 mg/dL during therapy, and if the recovery of (13)CO(2) from whole-body (13)C-galactose oxidation is reduced below 5% of administered (13)C-galactose. 11113841 2000
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.040 GeneticVariation disease BEFREE Epilepsy modulating neuropeptides (galanin, neuropeptide Y, dynorphin) are also involved. 30892153 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.030 GeneticVariation disease BEFREE Single-nucleotide polymorphism rs948854 in human galanin gene and multiple sclerosis: a gender-specific risk factor. 27870457 2017
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
Epilepsy, Temporal Lobe 		0.020 GeneticVariation disease BEFREE In a cohort of 582 cases, we did not observe any pathogenic mutations indicating that mutations in GAL are a rare cause of TLE. 25691535 2015