GAL, galanin and GMAP prepropeptide, 51083

N. diseases: 226; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4225318
Disease: EPILEPSY, FAMILIAL TEMPORAL LOBE, 8
EPILEPSY, FAMILIAL TEMPORAL LOBE, 8 		0.600 Biomarker disease CTD_human
CUI: C0149958
Disease: Complex partial seizures
Complex partial seizures 		0.100 Biomarker disease HPO
CUI: C0270834
Disease: Complex partial seizure with impairment of consciousness
Complex partial seizure with impairment of consciousness 		0.100 Biomarker disease HPO
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.010 Biomarker disease BEFREE <i>Bacillus anthracis</i>, the causative agent of anthrax disease, elaborates a secondary cell wall polysaccharide (SCWP) that is essential for bacterial growth and cell division.<i>B. anthracis</i> SCWP is comprised of trisaccharide repeats with the structure, [→4)-β-ManNAc-(1→4)-β-GlcNAc(<i>O</i>3-α-Gal)-(1→6)-α-GlcNAc(<i>O</i>3-α-Gal, <i>O</i>4-β-Gal)-(1→]<sub>6-12</sub> The genes whose products promote the galactosylation of <i>B. anthracis</i> SCWP are not yet known. 29229702 2018
CUI: C0014060
Disease: Encephalitis, St. Louis
Encephalitis, St. Louis 		0.010 AlteredExpression disease BEFREE SLE T-cells expressed lower amounts of Gal-1 than healthy T-cells and were less sensitive to exGal-1. 25468561 2015
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.010 AlteredExpression disease BEFREE SLE T-cells expressed lower amounts of Gal-1 than healthy T-cells and were less sensitive to exGal-1. 25468561 2015
CUI: C0020757
Disease: Ichthyoses
Ichthyoses 		0.010 Biomarker disease BEFREE Ichthyoses lacked the epidermal differentiation and tight junction alterations of patients with AD (loricrin, filaggrin, and claudin 1) but showed characteristic alterations in lipid metabolism genes (ELOVL fatty acid elongase 3 and galanin), with parallel reductions in extracellular lipids and corneocyte compaction in all ichthyoses except epidermolytic ichthyosis, suggesting phenotypic variations. 29803800 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.040 GeneticVariation disease BEFREE Epilepsy modulating neuropeptides (galanin, neuropeptide Y, dynorphin) are also involved. 30892153 2019
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.060 Biomarker disease BEFREE Galanin binding was measured on endogenous galanin type 1 receptors in the Bowes neuroblastoma cell line. 10415087 1999
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.050 Biomarker disease BEFREE Galanin binding was measured on endogenous galanin type 1 receptors in the Bowes neuroblastoma cell line. 10415087 1999
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.050 Biomarker disease BEFREE Galanin binding was measured on endogenous galanin type 1 receptors in the Bowes neuroblastoma cell line. 10415087 1999
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE GAL peptide concentrations up to 674 +/- 166 fmol/mg of tissue were detected by radioimmunoassay, but no significant correlation with standard tumor markers or the prognosis of the 14 patients investigated was observed. 11867941 2002
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.030 AlteredExpression disease BEFREE Gal-1 mRNA levels were increased in more than 95% of the examined ovary carcinoma samples, compared with a wedge resection of a normal ovary. 12649338 2003
CUI: C0085136
Disease: Central Nervous System Neoplasms
Central Nervous System Neoplasms 		0.010 Biomarker group BEFREE Galanin-like immunoreactivity (GAL-LI) and specific GAL binding sites have been shown to be widely distributed in the central nervous system (CNS) and in CNS tumors. 12734662 2003
CUI: C0242852
Disease: Proliferative vitreoretinopathy
Proliferative vitreoretinopathy 		0.010 Biomarker disease BEFREE Gal-1 mRNA expression was present in human specimens of PVR membranes, and staining for Gal-1 was distributed throughout the extracellular matrix (ECM) of PVR membranes. 16384992 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Gal-1(hi) expression was associated with male gender, older patients, reduced CD8(+) T cell infiltration at the tumor site, and most importantly, an impaired latent membrane protein 1 and 2-specific CD8(+) T-cell responses. 17438085 2007
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.010 AlteredExpression disease BEFREE Galanin is up-regulated in colon adenocarcinoma. 18006926 2007
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.080 Biomarker disease BEFREE GAL fiber hyperinnervation of cholinergic NB neurons upregulates the expression of ChAT, the synthetic enzyme for ACh, suggesting that GAL regulates the cholinergic tone of CBF neurons in AD. 18322398 2008
CUI: C1333064
Disease: Classical Hodgkin's Lymphoma
Classical Hodgkin's Lymphoma 		0.020 AlteredExpression disease BEFREE Gal1 is selectively expressed by malignant Reed-Sternberg cells in >90% of primary cHLs, and Gal1 expression is concordant with the activated AP1 component, c-Jun. 18519761 2008
CUI: C2347747
Disease: Adult Classical Hodgkin Lymphoma
Adult Classical Hodgkin Lymphoma 		0.020 AlteredExpression disease BEFREE Gal1 is selectively expressed by malignant Reed-Sternberg cells in >90% of primary cHLs, and Gal1 expression is concordant with the activated AP1 component, c-Jun. 18519761 2008
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE GAL, coding for the neuropeptide galanin, and GALR1, a galanin receptor, were identified as candidate genes of oncogenesis in SCC. 18973137 2009
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.050 Biomarker disease BEFREE GAL, coding for the neuropeptide galanin, and GALR1, a galanin receptor, were identified as candidate genes of oncogenesis in SCC. 18973137 2009
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.050 AlteredExpression disease BEFREE Gal-1 is highly expressed in the invasive front of primary tumors and in the cancer cells of metastatic lesions in the lymph nodes of patients with oral squamous cell carcinoma. 19276182 2009
CUI: C0278996
Disease: Malignant Head and Neck Neoplasm
Malignant Head and Neck Neoplasm 		0.030 Biomarker disease BEFREE Galanin receptor subtype 2 suppresses cell proliferation and induces apoptosis in p53 mutant head and neck cancer cells. 19276245 2009
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma 		0.030 Biomarker disease BEFREE Galanin receptor subtype 2 suppresses cell proliferation and induces apoptosis in p53 mutant head and neck cancer cells. 19276245 2009