|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, intraperitoneal injection of a galanin antagonist reduced MMCs and inhibited the inflammation of dextran sodium sulfate-induced colitis in mice.
|
31706262 |
2020 |
|
Post-kala-azar dermal leishmaniasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We developed Gal enzyme-linked immunosorbent assay to measure specific anti-gal IgG isotype in the sera of 71 Indian patients with PKDL.
|
31397399 |
2020 |
|
Ichthyoses
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ichthyoses lacked the epidermal differentiation and tight junction alterations of patients with AD (loricrin, filaggrin, and claudin 1) but showed characteristic alterations in lipid metabolism genes (ELOVL fatty acid elongase 3 and galanin), with parallel reductions in extracellular lipids and corneocyte compaction in all ichthyoses except epidermolytic ichthyosis, suggesting phenotypic variations.
|
29803800 |
2019 |
|
Immune System Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Galectin 1(Gal-1), a β-galactoside binding mammalian lectin of 14KDa, is implicated in many signalling pathways, immune responses associated with cancer progression and immune disorders.
|
30834831 |
2019 |
|
Neck Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In this issue of the JCI, Nambiar et al. used patient head and neck tumors and a mouse model system to investigate the role of galactose-binding lectin 1 (Gal1) in immunotherapy resistance.
|
31710312 |
2019 |
|
Hyperkeratosis, Epidermolytic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ichthyoses lacked the epidermal differentiation and tight junction alterations of patients with AD (loricrin, filaggrin, and claudin 1) but showed characteristic alterations in lipid metabolism genes (ELOVL fatty acid elongase 3 and galanin), with parallel reductions in extracellular lipids and corneocyte compaction in all ichthyoses except epidermolytic ichthyosis, suggesting phenotypic variations.
|
29803800 |
2019 |
|
Left Ventricular Hypertrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The serum lyso-Gb3 level can be relevant for clinically significant FD, and combined measurement of lyso-Gb3 and α-GAL can provide better screening of FD in unexplained LVH patients.
|
31308318 |
2019 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study was designed to assess the ability of the full-length galanin (GWTLNSAGYLLGPHAIDNHRSFSDKHGLT-NH2, G1), the natural fragments WTLNSAGYLL-NH2 (G2) and WTLNSAGYLLGPHA (G3), and their modified analogs WTLNAAGYLL (G4) and WTLNSAGYLLGPβAH (G5) to limit acute myocardial infarction in rats in vivo.
|
29730241 |
2019 |
|
Anhedonia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
|
31081442 |
2019 |
|
Memory impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Moreover, GAL(1-15) reversed the effects of memory impairment induced by FLX(10 mg/kg) in the Novel Object Recognition task.
|
31128121 |
2019 |
|
Physical addiction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Preclinical studies have demonstrated that galanin affects physical dependence and rewarding actions associated with morphine.
|
31135380 |
2019 |
|
Forgetful
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Moreover, GAL(1-15) reversed the effects of memory impairment induced by FLX(10 mg/kg) in the Novel Object Recognition task.
|
31128121 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, galanin mRNA and protein expression levels in the preoperative samples from patients with gastric cancer were significantly correlated with lymph node metastasis, tumor node metastasis stage, and size of the gastric cancer.
|
30616468 |
2019 |
|
Malignant Peripheral Nerve Sheath Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gal-1 was upregulated in MPNST patients and was highly expressed in MPNST cells.
|
31127849 |
2019 |
|
Lewy Body Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Galanin immunohistochemistry was carried out in the anterior nucleus basalis of Meynert of 27 Parkinson's disease (PD) cases without cognitive impairment (mild cognitive impairment [MCI]), 15 with PD with MCI, 42 with Parkinson's disease dementia (PDD), 12 with Dementia with Lewy bodies (DLB), 19 with AD, 12 mixed AD/DLB and 16 controls.
|
31454423 |
2019 |
|
Spondylometaphyseal dysplasia with dentinogenesis imperfecta
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In spite of reduced abundance, residual GMAP variants maintain partial Golgi integrity, normal global protein secretion, and subcellular distribution of IFT20 in ODCD.
|
30728324 |
2019 |
|
Anthrax disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>Bacillus anthracis</i>, the causative agent of anthrax disease, elaborates a secondary cell wall polysaccharide (SCWP) that is essential for bacterial growth and cell division.<i>B. anthracis</i> SCWP is comprised of trisaccharide repeats with the structure, [→4)-β-ManNAc-(1→4)-β-GlcNAc(<i>O</i>3-α-Gal)-(1→6)-α-GlcNAc(<i>O</i>3-α-Gal, <i>O</i>4-β-Gal)-(1→]<sub>6-12</sub> The genes whose products promote the galactosylation of <i>B. anthracis</i> SCWP are not yet known.
|
29229702 |
2018 |
|
Patent ductus arteriosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gal-1 sensitivity and specificity values were similar to that of the CA19-9 biomarker (the only FDA-approved blood test biomarker for PDA), and the combination of Gal-1 and CA19-9 significantly improved their individual discriminatory powers.
|
30250644 |
2018 |
|
Heart Block
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report that photostimulation of VLPO<sup>GAL</sup> neurons in mice promotes sleep with low frequency stimulation (1-4 Hz), but causes conduction block and waking at frequencies above 8 Hz.
|
30297727 |
2018 |
|
Keratoconus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ultrastructural analysis of keratocytes showed a marked increase of endogenous Gal-3 levels, but not Gal-1, in KC.
|
29439091 |
2018 |
|
Periodontal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Both ADM and GAL potentially are new candidates to consider as biomolecules associated with periodontal disease activity.
|
29676776 |
2018 |
|
Depressive Symptoms
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Implication of galanin gene rs948854 polymorphism in depressive symptoms in adolescents.
|
28987550 |
2018 |
|
Malignant neoplasm of mouth
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Recently, GALR1 was also suggested as a tumor suppressor gene that was frequently silenced in head and neck squamous cell carcinoma; moreover, galanin and GALR1 were reported to inhibit human oral cancer cell proliferation.
|
29462183 |
2018 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Recently, GALR1 was also suggested as a tumor suppressor gene that was frequently silenced in head and neck squamous cell carcinoma; moreover, galanin and GALR1 were reported to inhibit human oral cancer cell proliferation.
|
29462183 |
2018 |
|
Neuromuscular inhibition
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neurite outgrowth in vitro and erectile response to electrostimulation after BCNI in vivo, immunohistochemical localization of galanin and receptors, and penile muscle relaxation in vitro.
|
29550465 |
2018 |