Fanconi Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results suggest a role for the FA core complex in regulating Rev1-dependent DNA damage tolerance independently of FANCD2, FANCI, and PCNA monoubiquitination.
|
18448394 |
2008 |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results suggest a role for the FA core complex in regulating Rev1-dependent DNA damage tolerance independently of FANCD2, FANCI, and PCNA monoubiquitination.
|
18448394 |
2008 |
Brucella melitensis infection
|
0.020 |
Biomarker
|
disease |
BEFREE |
Live attenuated Brucella melitensis Rev 1 is the most effective vaccine against brucellosis in small ruminants.
|
17050051 |
2007 |
Malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
|
15609317 |
2005 |
Carcinoma of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
|
15609317 |
2005 |
Primary malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
|
15609317 |
2005 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
The DNA repair protein- Fanconi anemia complementation group F protein (FANCF) and the translesion synthesis DNA polymerase REV1 protein is frequently abundant in the context of mutant p53 of BrCa.
|
31511498 |
2019 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The DNA repair protein- Fanconi anemia complementation group F protein (FANCF) and the translesion synthesis DNA polymerase REV1 protein is frequently abundant in the context of mutant p53 of BrCa.
|
31511498 |
2019 |
Brucellosis in animals
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>Brucella abortus</i> strain 19 (S19), <i>Brucella melitensis</i> Rev 1 (Rev1), and <i>B. abortus</i> strain RB51 (RB51) are the three licensed animal brucellosis vaccines, and they have been most commonly and successfully used in prevent brucellosis in animals.
|
29867505 |
2018 |
Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, survival and mutagenesis assays in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells treated with cisplatin and ultraviolet light indicate that these compounds inhibit mutagenic Rev1/Polζ-dependent TLS in cells, validating the Rev1-CT/RIR PPI for future anticancer drug discovery and identifying the first small molecule inhibitors of TLS that target Rev1-CT.
|
28541665 |
2017 |
Adult Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, survival and mutagenesis assays in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells treated with cisplatin and ultraviolet light indicate that these compounds inhibit mutagenic Rev1/Polζ-dependent TLS in cells, validating the Rev1-CT/RIR PPI for future anticancer drug discovery and identifying the first small molecule inhibitors of TLS that target Rev1-CT.
|
28541665 |
2017 |
Leukopenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic REV1 rs3087403 allele and REV1 TGT haplotype were associated with increased risk for leukopenia (p = 0.013 and p = 0.047, respectively) and neutropenia (p = 0.048 and p = 0.024, respectively).
|
24956248 |
2014 |
Neutropenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic REV1 rs3087403 allele and REV1 TGT haplotype were associated with increased risk for leukopenia (p = 0.013 and p = 0.047, respectively) and neutropenia (p = 0.048 and p = 0.024, respectively).
|
24956248 |
2014 |
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined coordinated gene expression patterns of ligand/receptor (L/R) pairs using the L/R database DRLP-rev1 and five publicly available thyroid cancer datasets of gene expression on a total of 41 paired PTC/normal thyroid tissues.
|
20877637 |
2010 |
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined coordinated gene expression patterns of ligand/receptor (L/R) pairs using the L/R database DRLP-rev1 and five publicly available thyroid cancer datasets of gene expression on a total of 41 paired PTC/normal thyroid tissues.
|
20877637 |
2010 |
Papillary thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined coordinated gene expression patterns of ligand/receptor (L/R) pairs using the L/R database DRLP-rev1 and five publicly available thyroid cancer datasets of gene expression on a total of 41 paired PTC/normal thyroid tissues.
|
20877637 |
2010 |
Thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined coordinated gene expression patterns of ligand/receptor (L/R) pairs using the L/R database DRLP-rev1 and five publicly available thyroid cancer datasets of gene expression on a total of 41 paired PTC/normal thyroid tissues.
|
20877637 |
2010 |
Cervical Squamous Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Compared with the REV1 Phe257Ser, women carrying Ser257Ser and Phe257Ser genotypes had a significantly decreased the risk for cervical carcinoma or cervical squamous cell carcinoma.
|
18470628 |
2008 |
Cervix carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Compared with the REV1 Phe257Ser, women carrying Ser257Ser and Phe257Ser genotypes had a significantly decreased the risk for cervical carcinoma or cervical squamous cell carcinoma.
|
18470628 |
2008 |
Human papilloma virus infection
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNPs) (REV1 Phe257Ser and REV1 Asn373Ser) were genotyped by PCR-squencing, and analysis the correlation to clinical character including HPV infection.
|
18470628 |
2008 |