|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TT genotype of exon 21 MDR1 polymorphisms is associated with a higher risk of CsA failure in patients with steroid resistant UC.
|
17206635 |
2007 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Differences in P-glycoprotein-170 expression and activity between Crohn's disease and ulcerative colitis.
|
10439313 |
1999 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we found that protein expression of ABCB1 (ATP Binding Cassette Subfamily B Member 1) / MDR1 (multidrug resistance 1) was diminished in the intestinal mucosa of patients with active UC with or without CAC, but not in non-UC patients with sporadic colon cancer.
|
28686677 |
2017 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether common MDR1 variants were associated with UC in the genetically heterogeneous North Indian population.
|
19005421 |
2009 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of both efflux transporters BCRP and MDR1 is reduced, but only in inflamed tissue of patients with active UC.
|
19052456 |
2008 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, active UC in patients carrying the TLR2-R753Q and MDR1-C3435T polymorphisms was associated with increased nuclear expression of caspase-1 protein and cell death in areas of acute inflammation, compared with active UC patients without these variants.
|
23636052 |
2013 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We tried to determine the frequency of C3435T polymorphism of the MDR1 gene in Iranian patients with ulcerative colitis and to compare it with a healthy control population.
|
17242936 |
2007 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated DNA methylation of the MDR1 gene in ulcerative colitis (UC) and its relation to MDR1 C3435T genotypes.Eighty-three UC patients were enrolled.
|
19288029 |
2009 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MDR1 gene variants and haplotypes were associated with UC in Serbian IBD patients, further supporting their potential role in susceptibility to UC.
|
29543864 |
2018 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that the increase in P-glycoprotein expression from normal to inflamed and dysplastic areas reflects the premalignant nature of ulcerative colitis and occurs early in the course of the disease.
|
1353719 |
1992 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Messenger RNA expression of ABCB1 (MDR1) and PXR was significantly reduced in the colon of patients with UC but was unaffected in patients with Crohn's disease.
|
15236169 |
2004 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Three hundred eighty-eight German IBD patients [244 with Crohn's disease (CD), 144 with ulcerative colitis (UC)] and 1,005 German healthy controls were genotyped for the two MDR1 SNPs on positions 2677G>T/A and 3435C>T.
|
17665184 |
2007 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
LHGDN |
We investigated whether common MDR1 variants were associated with UC in the genetically heterogeneous North Indian population.
|
19005421 |
2009 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis.
|
12512026 |
2003 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
LHGDN |
This 'candidate gene' approach provides compelling evidence to support the contribution of the ABCB1/MDR1 gene in determining risk to UC but not to CD and provides new insights into the localization of the critical susceptibility determinants within the gene.
|
16434479 |
2006 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese.
|
16462040 |
2006 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
The amounts of MDR1 mRNA in PBMCs of UC patients having experienced GC therapy significantly correlated with the total dose of GCs administered (p = 0.0175).
|
15102868 |
2004 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC.
|
16374256 |
2006 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
In patients with extensive UC a significantly different distribution of genotypes of the MDR1 G/A change located in intron 3 (rs3789243) was observed between carriers/noncarriers of the -25385T risk allele (P = 0.005).
|
17828778 |
2007 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis.
|
16773678 |
2006 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Three hundred eighty-eight German IBD patients [244 with Crohn's disease (CD), 144 with ulcerative colitis (UC)] and 1,005 German healthy controls were genotyped for the two MDR1 SNPs on positions 2677G>T/A and 3435C>T.
|
17665184 |
2007 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|