ATG16L1, autophagy related 16 like 1, 55054

N. diseases: 120; N. variants: 31
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE MAP, rs2241880 (ATG16L1) and rs10045431 (IL12B) were found to be significantly associated with CD. 24522266 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The aim of the present study was to investigate the genetic polymorphisms of the autophagy-associated genes autophagy-related 16-like 1 (ATG16L1), immunity-related GTPase M (IRGM), Unc-51-like kinase 1 (ULK1), and NOD2 with respect to early-onset Crohn disease (CD) among Korean children. 25944217 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The ATG16L1 T300A polymorphism contributes to susceptibility to CD and UC in adults, but different in children, which implicates a role for autophagy in the pathogenesis of IBD. 20222171 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The critical next step is functional characterization of the CD-associated genetic variants in IRGM and ATG16L. 17921695 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians. 19337756 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. 17200669 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 17554300 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Conclusion In this meta-analysis, the ATG16L1 genotype was significantly associated with the risk of developing Crohn's disease. 27698206 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease LHGDN Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease. 17625155 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE All nine ATG16L1 gene variants analyzed displayed highly significant associations with CD demonstrating a CD-protective effect for the minor allele. 18162085 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The association of ATG16L1 T300A with CD was confirmed [P = 0.004, odds ratio (OR) = 1.69, 95% CI: 1.19-2.41], and both IL23R variants were found to represent significant risk for the disease (P = 0.008, OR = 2.05, 95% CI: 1.20-3.50 for rs1004819 AA; P < 0.001, OR = 2.97, 95% CI: 1.65-5.33 for rs2201841 CC). 20066736 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE In contrast to the North American population, PHOX2B, NCF4, FAM92B, and rs224136 are not associated with CD in the European population, whereas NOD2/CARD15, IL23R, and ATG16L1 are strongly associated with CD in both the North American and European populations, confirming these three genes as major CD susceptibility genes in Caucasian populations. 19262523 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients. 29487628 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE The associated polymorphisms in ATG16L1 and IRGM have been confirmed, and functional studies have begun to shed light on how they link to CD pathogenesis. 21830281 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Autophagy-related 16 like-1 (ATG16L-1), immunity-related GTPase-M (IRGM), and nucleotide-binding oligomerization domain-containing 2 (NOD2) regulate autophagy, and variants in these genes have been associated with predisposition to Crohn's disease (CD). 22285936 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE We found a genetic interaction between reference SNP (rs)2241880 (ATG16L1) and rs10065172 (IRGM) in CD. 24247223 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously identified as a risk factor in Crohn's disease (CD), was associated with more favourable clinical outcomes in thyroid cancer. 25645662 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable. 18366306 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Two SNPs (rs2241880 and rs6754677) in the ATG16L1 gene were significantly associated with the onset of CD in the Malaysian population. 31654602 2020
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15; rs2241880 A/G of ATG16L1, and rs11209026 (rs11209026;rs901312933" genes_norm="149233;55054">R381Q) of IL23R gene were assessed in 110 childhood-onset CD, 364 adult-onset CD, and 539 healthy individuals. 20380008 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE A genome-wide association study has shown an association of Crohn's disease with the autophagy related 16-like 1 gene. 19026604 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE ATG16L1 and IL23R variants and genetic susceptibility to crohn's disease: mode of inheritance based on meta-analysis of genetic association studies. 25738374 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. 17484864 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE We confirmed the association of CD with ATG16L1 rs2241880 variant in early-onset CD. 19659808 2009