ATG16L1, autophagy related 16 like 1, 55054

N. diseases: 120; N. variants: 31
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. 20144769 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease BEFREE ATG16L1 and NOD2 were found to contribute independently to CD risk. 18671817 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease BEFREE ATG16L1 and NOD2 are components of an autophagy-mediated antibacterial pathway that is altered in a cell- and function-specific manner by CD-associated mutations. 20637199 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease BEFREE ATG16L1 and TNFSF15 are associated with CD in Taiwan. 21930071 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Autophagy-related 16 like-1 (ATG16L-1), immunity-related GTPase-M (IRGM), and nucleotide-binding oligomerization domain-containing 2 (NOD2) regulate autophagy, and variants in these genes have been associated with predisposition to Crohn's disease (CD). 22285936 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease BEFREE ATG16L1, an essential component for autophagy and a risk gene for Crohn's disease, contains two binding sites in the 3'UTR for miR-17 family, including miRs-20a, -93, -106a, and -106b. 23899543 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE ATG16L1 and IL23R variants and genetic susceptibility to crohn's disease: mode of inheritance based on meta-analysis of genetic association studies. 25738374 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease BEFREE ATG16L1, a protein essential for early stages of autophagy, has been implicated in the pathogenesis of Crohn's disease. 25767270 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 AlteredExpression disease BEFREE ATG16L1 and LC3 expression was analyzed in the inflamed ileum and colon of 28 patients with Crohn's disease (CD), 14 with ulcerative colitis (UC) and 23 controls by western blot. 27335178 2016
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE ATG16L1 polymorphisms have been linked to the development of Crohn's disease (CD), and phosphorylation of CD-associated ATG16L1 T300A (caATG16L1) has been hypothesized to contribute to cleavage and autophagy dysfunction. 31267703 2019
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE Thr300Ala polymorphism in ATG16L1 was reported as a susceptibility factor to Crohn's disease (CD). 19575361 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE A genetic risk factor associated specifically with Crohn's disease is a variant in ATG16L1 that reduces autophagy. 27435106 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. 17200669 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease LHGDN A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. 17200669 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE A genome-wide association study has shown an association of Crohn's disease with the autophagy related 16-like 1 gene. 19026604 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASCAT A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. 22936669 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. 22936669 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASCAT A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. 22412388 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASDB A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. 22412388 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. 17484864 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 Biomarker disease LHGDN A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. 17484864 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE All nine ATG16L1 gene variants analyzed displayed highly significant associations with CD demonstrating a CD-protective effect for the minor allele. 18162085 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE An alteration in ATG16L1 stability in Crohn disease. 25136803 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016