|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
ATG16L1 and TNFSF15 are associated with CD in Taiwan.
|
21930071 |
2011 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
MAP, rs2241880 (ATG16L1) and rs10045431 (IL12B) were found to be significantly associated with CD.
|
24522266 |
2014 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
ATG16L1, a protein essential for early stages of autophagy, has been implicated in the pathogenesis of Crohn's disease.
|
25767270 |
2015 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis.
|
22346247 |
2012 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
IRGM, NOD2, and ATG16L1, all of which are Crohn's disease risk factors, form a molecular complex to modulate autophagic responses to microbial products.
|
25891078 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the genetic polymorphisms of the autophagy-associated genes autophagy-related 16-like 1 (ATG16L1), immunity-related GTPase M (IRGM), Unc-51-like kinase 1 (ULK1), and NOD2 with respect to early-onset Crohn disease (CD) among Korean children.
|
25944217 |
2015 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
With the recent completion of the human genome project, whole genome association studies (WGAS) have now become possible and have identified additional genes (IL23R, IRGM, PTGER4, ATG16L1) for Crohn's disease and ulcerative colitis, that have subsequently been replicated.
|
18473763 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The ATG16L1 T300A polymorphism contributes to susceptibility to CD and UC in adults, but different in children, which implicates a role for autophagy in the pathogenesis of IBD.
|
20222171 |
2010 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Indeed, genes important in the regulation of the IL-17-IL-23 pathway and, in Crohn's disease, genes important for autophagy (that is, NOD2 and ATG16L1 and IRGM) have a role in conferring susceptibility of individuals to these diseases.
|
22487796 |
2012 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
We found strong evidence of CD-association for 195 genes, identifying novel susceptibility genes (e.g., ISX, SLCO6A1, TMEM183A) as well as confirming many previously identified susceptibility genes in CD GWAS (e.g., IL23R, NOD2, CYLD, NKX2-3, IL12RB2, ATG16L1).
|
23071489 |
2012 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
In particular, the importance of the innate immune system has been reaffirmed with the identification of IRGM and ATG16L1 genes in the autophagy pathway as CD susceptibility genes.
|
19897957 |
2009 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
ATG16L1 and NOD2 are components of an autophagy-mediated antibacterial pathway that is altered in a cell- and function-specific manner by CD-associated mutations.
|
20637199 |
2010 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The critical next step is functional characterization of the CD-associated genetic variants in IRGM and ATG16L.
|
17921695 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians.
|
19337756 |
2009 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.
|
17200669 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Conclusion In this meta-analysis, the ATG16L1 genotype was significantly associated with the risk of developing Crohn's disease.
|
27698206 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease.
|
17625155 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
All nine ATG16L1 gene variants analyzed displayed highly significant associations with CD demonstrating a CD-protective effect for the minor allele.
|
18162085 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association of ATG16L1 T300A with CD was confirmed [P = 0.004, odds ratio (OR) = 1.69, 95% CI: 1.19-2.41], and both IL23R variants were found to represent significant risk for the disease (P = 0.008, OR = 2.05, 95% CI: 1.20-3.50 for rs1004819 AA; P < 0.001, OR = 2.97, 95% CI: 1.65-5.33 for rs2201841 CC).
|
20066736 |
2010 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In contrast to the North American population, PHOX2B, NCF4, FAM92B, and rs224136 are not associated with CD in the European population, whereas NOD2/CARD15, IL23R, and ATG16L1 are strongly associated with CD in both the North American and European populations, confirming these three genes as major CD susceptibility genes in Caucasian populations.
|
19262523 |
2009 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Low serum zinc levels predict presence of depression symptoms, but not overall disease outcome, regardless of ATG16L1 genotype in Crohn's disease patients.
|
29487628 |
2018 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Gene-gene interaction analysis revealed significant interactions between MST1 and other susceptibility genes, including NOD2, MUC19 and ATG16L1 in contributing to Crohn's disease risk.
|
29441677 |
2018 |