|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Twenty one patients with IBD (10 with ulcerative colitis (UC), 11 with Crohn's disease (CD)), seven disease specificity controls (DSC), and seven healthy controls were studied.
|
11171821 |
2001 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.
|
17200669 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.
|
17200669 |
2007 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.
|
17435756 |
2007 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
We confirmed the findings that ATG16L1 is a CD susceptibility gene and found no evidence of interaction with CARD15, IL23R, or IBD5.
|
17455206 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.
|
17484864 |
2007 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
LHGDN |
A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.
|
17484864 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recently, positive association of CD with the variants in interleukin 23 receptor (IL23R), autophagy-related 16-like 1 (ATG16L1) genes and chromosome 5p13.1 locus was reported through genome-wide association studies which are now recognised as a robust tool for the identification of susceptibility genes for complex diseases.
|
17534574 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease.
|
17625155 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
|
17684544 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We replicated the previously reported associations between CD and rs11209026 and rs2241880, confirming that IL23R and ATG16L1 are susceptibility loci for CD in the New Zealand population.
|
17894849 |
2007 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
LHGDN |
We replicated the previously reported associations between CD and rs11209026 and rs2241880, confirming that IL23R and ATG16L1 are susceptibility loci for CD in the New Zealand population.
|
17894849 |
2007 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The critical next step is functional characterization of the CD-associated genetic variants in IRGM and ATG16L.
|
17921695 |
2008 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
LHGDN |
The critical next step is functional characterization of the CD-associated genetic variants in IRGM and ATG16L.
|
17921695 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Five hundred eighteen Dutch white IBD patients (311 CD and 207 UC, including 176 trios of patients with both parents), 508 celiac disease patients, and 893 healthy controls were studied for association with the rs11209026 (IL23R) and rs2241880 (ATG16L1) single nucleotide polymorphisms (SNP).
|
18047540 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to assess whether germline variation of ATG16L1 acts as an independent determinant of susceptibility to childhood-onset CD in the high-incidence Scottish population.
|
18088053 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
All nine ATG16L1 gene variants analyzed displayed highly significant associations with CD demonstrating a CD-protective effect for the minor allele.
|
18162085 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping for CARD15 (R702W, G908R, 3020insC), IL23R (rs1004819, rs7517847, rs11209026, rs10889677, rs1495965), and ATG16L1 (rs2241880) was performed in 187 children and adults with CD and 255 healthy ethnically matched controls.
|
18200510 |
2008 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
LHGDN |
With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable.
|
18366306 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
With respect to ATG16L1, the G allele of SNP rs2241880 has been shown in multiple association studies to confer strong risk for CD, although its association with UC remains more debatable.
|
18366306 |
2008 |