|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
One patient had direct cytological diagnosis of PTC also did not undergo surgical resection/diagnosis due to the advanced primary pancreatic adenocarcinoma.
|
28261999 |
2017 |
|
Adenocarcinoma, Oxyphilic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
CCI = Charlson Comorbidity Index; CCR = California Cancer Registry; CI = confidence interval; DTC = differentiated thyroid cancer; FTC = follicular thyroid carcinoma; HCC = Hürthle cell carcinoma; IQR = interquartile range; mPTC = papillary thyroid micro-carcinoma; OR = odds ratio; OSPHD = Office of Statewide Health Planning and Development; PTC = papillary thyroid carcinoma.
|
28816539 |
2017 |
|
Adenocarcinoma, Oxyphilic
|
0.020 |
Biomarker
|
disease |
BEFREE |
RNA was isolated from multinodular goiter (MNG; n=6), papillary carcinoma (PTC, n=14), follicular carcinoma (FC; n=5), and Hürthle cell carcinoma (HCC; n=7).
|
24559275 |
2014 |
|
Adenocarcinoma, Tubular
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data showed that PTC and TC-CIS were more likely to be smaller in size (<i>P</i>=0.014) and had substantially less nodal involvement (<i>P</i>=0.019), compared with TC-IC.
|
30349383 |
2018 |
|
Adenoma
|
0.030 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry analysis showed that Skp2 was overexpressed significantly in thyroid carcinomas (26 out of 51) compared with goitres (0 out of 12, P<0.001) or adenomas (1 out of 10, P<0.05), and that high Skp2 expression was detected more often in anaplastic thyroid (ATC; 83%, n=12) than follicular thyroid (FTC; 40%, n=20) or papillary thyroid (PTC; 42%, n=19) carcinomas (P<0.05).
|
17639054 |
2007 |
|
Adenoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
The frequency, if we consider exclusively the papillary carcinomas, is in both cases 12%; (b) show that the TRK oncogene plays a role in the development of a minority of radiation-associated papillary thyroid carcinomas but not in adenomas; and (c) confirm that RET/PTC rearrangements are the major genetic alteration associated with ionizing radiation-induced thyroid tumorigenesis.
|
10646882 |
2000 |
|
Adenoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Ret/PTC rearrangements were identified in 42.9% of thyroid carcinoma and 46.2% of adenoma subjects.
|
15126554 |
2004 |
|
Adenoma of large intestine
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using a case-control study of 914 colorectal adenoma cases/1188 controls, we explored associations among colorectal adenoma risk, dietary intake, and genetic variation in 3 bitter-taste receptor genes: TAS2R38 (rs713598, rs1726866, rs10246939), TAS2R16 (rs846672), and TAS2R50 (rs1376251).
|
24083639 |
2013 |
|
Adenomatous goiter
|
0.020 |
Biomarker
|
disease |
BEFREE |
Detection of retTPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method.
|
1717926 |
1991 |
|
Adenomatous goiter
|
0.020 |
Biomarker
|
disease |
BEFREE |
Analysis by a reverse transcriptase-polymerase chain reaction method showed that the ret rearrangement-positive tumor contained the PTC/retTPC chimeric transcript, which was reported to be found specifically in thyroid tumors and adenomatous goiter.
|
1381340 |
1992 |
|
Adenomatous polyp of colon
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study examined bitter taste genetics and whether variation in the TAS2R38 gene at three polymorphic loci (A49P, V262A and I296V) could alter dietary and systemic folate levels and dietary vitamin C intake, and whether a nutrigenetic circuit existed that might link bitter taste, folate/antioxidant status and risk for a colonic adenomatous polyp.
|
21769326 |
2011 |
|
Adenomatous Polyposis Coli
|
0.040 |
Biomarker
|
disease |
BEFREE |
However, the incidence and the nature of CMV-PTC among FAP patients have not been well characterized.
|
27623068 |
2016 |
|
Adenomatous Polyposis Coli
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Present data suggest that: (1) the incidence of FAP-associated thyroid cancer probably has been underestimated in the past; (2) intensive screening could detect a larger than expected number of thyroid carcinomas; (3) systematic screening is recommended in patients with ocular patches and genetic mutation in exon 15; (4) Hashimoto-like findings do not exclude carcinoma but are a frequent accompanying finding; (5) despite frequent multicentricity and early lymph node involvement, FAP-associated thyroid tumors seem to have an excellent prognosis, in particular those showing ret-PTC activation.
|
9841749 |
1998 |
|
Adenomatous Polyposis Coli
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Mutations of <i>APC</i> gene are found in the patients with CMV-PTC associated with FAP.
|
28314770 |
2017 |
|
Adenomatous Polyposis Coli
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We report a FAP-associated CMVPTC tumor with atypically aggressive features harboring a RAS mutation and review the molecular mechanisms associated with this interesting PTC subtype.
|
24702198 |
2014 |
|
Adenomatous Polyps
|
0.010 |
Biomarker
|
disease |
BEFREE |
TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps.
|
21769326 |
2011 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Strikingly, the glioblastoma growth is significantly attenuated by PTC-209 in a murine orthotopic xenograft model.
|
29886801 |
2018 |
|
Ageusia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The following data were determined for all the volunteers: alimentary frequency by clinical dieticians; genotyping of the G145C polymorphism in the TAS2r38 gene; cognitive status; sensorial (visual and hearing) acuity and drugs related to ageusia or dysgeusia.
|
21763010 |
2012 |
|
airway disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Further studies are needed to more clearly determine how TAS2R38 genotype affects patient outcomes in chronic rhinosinusitis and other upper airway diseases.
|
25304231 |
2015 |
|
airway disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
T2R38 appears to be an important mediator of sinonasal epithelial defense, but further study is needed to more clearly determine how TAS2R38 genotype affects patient outcomes in CRS and other upper airway diseases.
|
23883809 |
2013 |
|
Alcohol abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.
|
17250611 |
2007 |
|
Alcohol Use Disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.
|
17250611 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.540 |
Biomarker
|
disease |
PSYGENET |
Implications for the genetic link between PTC taste status and alcoholism are discussed.
|
16712955 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.540 |
Biomarker
|
disease |
PSYGENET |
We used family-based association methods to test for association between TAS2R38 haplotypes and alcohol dependence as well as a measure of alcohol consumption (Maxdrinks) and age of onset of drinking behaviors in a sample of families densely affected with alcoholism.
|
17250611 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.540 |
GeneticVariation
|
disease |
BEFREE |
We used family-based association methods to test for association between TAS2R38 haplotypes and alcohol dependence as well as a measure of alcohol consumption (Maxdrinks) and age of onset of drinking behaviors in a sample of families densely affected with alcoholism.
|
17250611 |
2007 |