|
THIOUREA TASTING
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
|
Color blindness
|
0.020 |
Biomarker
|
disease |
BEFREE |
Colour-blindness and sensitivity to PTC in Hadza.
|
16431664 |
1975 |
|
Color blindness
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A low frequency of the PTC non-taster allele was found (t = 0.142 +/- 0.029) as was the overall frequency for colour blindness (cb = 0.013 +/- 0.009).
|
310801 |
1979 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The same structural alterations of PTC and TRK (gene rearrangements) as well as of N-RAS (point mutation) detected in the NIH3T3 transformants, were also found in the original tumour DNAs, thus indicating that their activation was not due to transfection procedures.
|
2594368 |
1989 |
|
Papillary thyroid carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since both PTC, a novel rearranged form of RET, and TRK display a tyrosine protein kinase activity, it is proposed that the activation of this class of oncogenes is specifically involved in the pathogenesis of papillary thyroid cancer.
|
2594368 |
1989 |
|
Carcinoma, Papillary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have recently reported the identification of a new oncogene, named PTC, frequently activated in human thyroid papillary carcinomas.
|
1701232 |
1990 |
|
Papillary thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that intrachromosomal rearrangements are responsible for PTC activation in papillary thyroid carcinomas.
|
2000227 |
1991 |
|
Thyroid Gland Follicular Adenoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Detection of retTPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method.
|
1717926 |
1991 |
|
Adenomatous goiter
|
0.020 |
Biomarker
|
disease |
BEFREE |
Detection of retTPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method.
|
1717926 |
1991 |
|
Alcoholic Intoxication, Chronic
|
0.540 |
Biomarker
|
disease |
BEFREE |
These results are inconsistent with the view that excessive use of alcohol causes the association between nontasting and alcoholism and are consistent with the view that there is a genetic association between PROP/PTC-tasting and alcoholism.
|
1641428 |
1992 |
|
Alcoholic Intoxication, Chronic
|
0.540 |
Biomarker
|
disease |
PSYGENET |
These results are inconsistent with the view that excessive use of alcohol causes the association between nontasting and alcoholism and are consistent with the view that there is a genetic association between PROP/PTC-tasting and alcoholism.
|
1641428 |
1992 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
We did not find any ret transcripts in papillary carcinomas negative for PTC activation, nor in normal thyroid and in non-papillary thyroid neoplasias.
|
1457350 |
1992 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the PTC/retTPC chimeric transcripts were detected in two PCs with the rearrangement by reverse transcription polymerase chain reaction.
|
1620547 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We did not find any ret transcripts in papillary carcinomas negative for PTC activation, nor in normal thyroid and in non-papillary thyroid neoplasias.
|
1457350 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis by a reverse transcriptase-polymerase chain reaction method showed that the ret rearrangement-positive tumor contained the PTC/retTPC chimeric transcript, which was reported to be found specifically in thyroid tumors and adenomatous goiter.
|
1381340 |
1992 |
|
Thyroid Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis by a reverse transcriptase-polymerase chain reaction method showed that the ret rearrangement-positive tumor contained the PTC/retTPC chimeric transcript, which was reported to be found specifically in thyroid tumors and adenomatous goiter.
|
1381340 |
1992 |
|
Adenomatous goiter
|
0.020 |
Biomarker
|
disease |
BEFREE |
Analysis by a reverse transcriptase-polymerase chain reaction method showed that the ret rearrangement-positive tumor contained the PTC/retTPC chimeric transcript, which was reported to be found specifically in thyroid tumors and adenomatous goiter.
|
1381340 |
1992 |
|
Papillary neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here we show the detection by in situ hybridisation, of activated ret transcripts in human thyroid papillary neoplasms that were positive for PTC activation by Southern blot analysis.
|
1457350 |
1992 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study questions the relevance of PTC/retTPC oncogene in the carcinogenesis of thyroid papillary carcinomas in the Saudi population.
|
8275421 |
1994 |
|
Thyroid Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study, the frequency of PTC/retTPC oncogene in thyroid tumors from Saudi Arabia was investigated.
|
8275421 |
1994 |
|
Papillary thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic background among races may contribute to the different frequencies of PTC/retTPC oncogene in thyroid papillary carcinoma.
|
8275421 |
1994 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This study questions the relevance of PTC/retTPC oncogene in the carcinogenesis of thyroid papillary carcinomas in the Saudi population.
|
8275421 |
1994 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas.
|
7566982 |
1995 |
|
Papillary thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PTC-1, the predominant form of PTC oncogene in human papillary thyroid carcinoma, encodes a fusion protein containing the N-terminus of H4 (D10S170) fused 5' to the ret tyrosine kinase domain.
|
7753554 |
1995 |
|
Papillary thyroid carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RET is activated, as RET/PTC oncogene, by somatic rearrangements which link the TK domain to a constitutive dimerization interface in papillary thyroid carcinomas.
|
8570194 |
1995 |