|
Alcoholic Intoxication, Chronic
|
0.540 |
GeneticVariation
|
disease |
BEFREE |
We develop a pharmacokinetic model describing how genetic variations in ADH1B, ADH1C, ADH7, ALDH2, and TAS2R38 affect consumption behavior, and alcohol and acetaldehyde levels over time in various tissues of individuals with a particular genotype to predict their susceptibility to alcohol dependence.
|
20714161 |
2010 |
|
Alcoholic Intoxication, Chronic
|
0.540 |
Biomarker
|
disease |
PSYGENET |
We develop a pharmacokinetic model describing how genetic variations in ADH1B, ADH1C, ADH7, ALDH2, and TAS2R38 affect consumption behavior, and alcohol and acetaldehyde levels over time in various tissues of individuals with a particular genotype to predict their susceptibility to alcohol dependence.
|
20714161 |
2010 |
|
Alcoholic Intoxication, Chronic
|
0.540 |
Biomarker
|
disease |
CTD_human |
We used family-based association methods to test for association between TAS2R38 haplotypes and alcohol dependence as well as a measure of alcohol consumption (Maxdrinks) and age of onset of drinking behaviors in a sample of families densely affected with alcoholism.
|
17250611 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.540 |
Biomarker
|
disease |
BEFREE |
These results are inconsistent with the view that excessive use of alcohol causes the association between nontasting and alcoholism and are consistent with the view that there is a genetic association between PROP/PTC-tasting and alcoholism.
|
1641428 |
1992 |
|
Alcoholic Intoxication, Chronic
|
0.540 |
Biomarker
|
disease |
BEFREE |
Implications for the genetic link between PTC taste status and alcoholism are discussed.
|
16712955 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.540 |
Biomarker
|
disease |
PSYGENET |
These results are inconsistent with the view that excessive use of alcohol causes the association between nontasting and alcoholism and are consistent with the view that there is a genetic association between PROP/PTC-tasting and alcoholism.
|
1641428 |
1992 |
|
Alexithymia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings suggest that: 1) alexithymia, in addition to the TAS2R38 polymorphism, may play a role in responsiveness to the aversive and bitter taste of PROP; and 2) alexithymia, in combination with other personality traits, may provide important insights for better understanding food liking.
|
26805725 |
2016 |
|
Anaplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
This review will cover several cellular signaling pathways and mechanisms, including RET/PTC, RAS, BRAF, Notch, p53, and histone deacetylase, which are identified to play roles in the transformation and dedifferentiation process, and therapies that target these pathways.
|
25260367 |
2014 |
|
Anaplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Compared with normal tissues, PTC had 307 out of 494 (60%) genes over-expressed, FTC had 137 out of 171 (80%) genes under-expressed, whereas PDTC had 92 out of 107 (86%) genes under-expressed, suggesting that gene downregulation is involved in tumour dedifferentiation.
|
19809427 |
2009 |
|
Anaplastic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Papillary thyroid carcinomas in humans are associated with the ret/PTC oncogene and, following loss of p53 function, may progress to anaplastic carcinomas.
|
10934169 |
2000 |
|
Anaplastic thyroid carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
All miRNAs of 'set 2' were significantly upregulated in PTC (p<0.004) and downregulated in ATC (p<0.03); in PDTC only 3/5 were downregulated (p<0.011).
|
19370508 |
2009 |
|
Anaplastic thyroid carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
There are limited therapy options for advanced thyroid cancer, including papillary and anaplastic thyroid cancer (PTC and ATC).
|
27259715 |
2016 |
|
Anaplastic thyroid carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Using Western blot analysis, we found that Sin1 and p-AKT were detected at a greater level in cultured primary cells from aggressive PTC compared with conventional PTC as well as in cell lines of medullary and anaplastic thyroid carcinoma.
|
25456951 |
2014 |
|
Anaplastic thyroid carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that many ATCs with papillary components are derived from BRAF-mutated PTC, because of the addition of p53 mutation.
|
15880523 |
2005 |
|
Anaplastic thyroid carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In conclusion, chromosomal abnormalities are frequent in ATCs associated with FTC, but uncommon in those associated with PTC and in ATCs with no associated differentiated thyroid cancer.
|
12729478 |
2003 |
|
Anaplastic thyroid carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We characterized and utilized mouse cell lines derived from PTC and ATC tumors arising in genetically engineered mice with thyroid-specific expression of endogenous Braf(V600E/WT) and deletion of either Trp53 (p53) or Pten.
|
24295207 |
2014 |
|
Anaplastic thyroid carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
The histologic distinction between PTC-PC and PTC's with a focal anaplastic thyroid cancer (ATC) component (denoted in the 2004 WHO classification as "papillary thyroid carcinoma with spindle and giant cell carcinoma", PTC-SGC) is debated, however the prognosis is thought to be different (excellent for PTC-PC, poor for PTC-SGC).
|
29976183 |
2018 |
|
Anorexia Nervosa
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Current data reinforce the impact of TAS2R38 gene on phenotypic and clinical outputs affecting obesity, showing significant associations with extreme weight conditions (i.e., obesity and anorexia nervosa), and changes in both olfactory capacity and immune traits.
|
27059147 |
2016 |
|
Ataxia Telangiectasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We characterized and utilized mouse cell lines derived from PTC and ATC tumors arising in genetically engineered mice with thyroid-specific expression of endogenous Braf(V600E/WT) and deletion of either Trp53 (p53) or Pten.
|
24295207 |
2014 |
|
Autoimmune thyroiditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
From the PTC patients, one had MNG and fvPTC, one MNG, lymphocytic thyroiditis and papillary pattern of PTC, one lymphocytic thyroiditis and fvPTC, and one MNG and papillary pattern of PTC.
|
16405407 |
2005 |
|
Bacterial Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The aim of this study is to investigate for the first time the relevance of TAS2R38 genetic variants in the susceptibility to bacterial infections associated with in vivo biofilm formation in chronic rhinosinusitis with nasal polyps (CRSwNP) patients.
|
29570813 |
2018 |
|
Basal Cell Nevus Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
While mutations of the PTC gene could not be detected in 4 BCNS-associated OKCs by direct DNA sequencing, 3 of 5 primary and 4 of 4 recurrent OKCs had several mutations of this gene.
|
15308259 |
2004 |
|
Basal Cell Nevus Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To find genetic alterations in PTC or other genes of the Shh/PTCH pathway in tumorous and non- tumorous samples from three families and to correlate them with the varying expression of disorders in presented nevoid basal cell carcinoma syndrome (NBCCS) phenotypes.
|
10554356 |
1999 |
|
Benign Neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The surgical resection specimen demonstrated 16 (25%) FVPTCs, five (8%) follicular thyroid carcinomas, one (2%) classical type PTC, and 41 (65%) benign tumors/nodules.
|
27219469 |
2016 |
|
Benign Neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Thyroid carcinomas that harbor RET/PTC oncogenes are well differentiated, relatively benign neoplasms compared with those expressing oncogenic RAS or BRAF mutations despite signaling through shared transforming pathways.
|
22158616 |
2012 |