|
Gastrointestinal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, the meta-analysis indicates that TAS2R38 diplotype minimally modified the GI neoplasm risk.
|
30663393 |
2019 |
|
Taste Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
We study the role of the TAS2R38 receptor in taste disorders with the aim of understanding if these can be genetically determined.
|
30675726 |
2019 |
|
Tumor Initiation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Strikingly, serial in vivo re-transplantation assays demonstrated a marked reduction in tumor initiation ability of recurrent MB cells upon re-transplantation of PTC-028-treated cells into secondary recipient mouse brains.
|
30348991 |
2019 |
|
Poorly differentiated carcinoma
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Histology was reviewed, and the patients were divided in the following three groups: poorly differentiated carcinoma [PDTC; group 1 (n = 27)]; papillary thyroid carcinoma with PDA [PTC with PDA; group 2 (n = 27)]; and follicular thyroid carcinoma with PDA [FTC with PDA; group 3 (n = 88)].
|
30673845 |
2019 |
|
Poorly Differentiated Thyroid Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Histology was reviewed, and the patients were divided in the following three groups: poorly differentiated carcinoma [PDTC; group 1 (n = 27)]; papillary thyroid carcinoma with PDA [PTC with PDA; group 2 (n = 27)]; and follicular thyroid carcinoma with PDA [FTC with PDA; group 3 (n = 88)].
|
30673845 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, the miR-96-3p is involved in PTC metastasis and invasion by direct targeting SDHB and the downstream molecule AKT and mTOR.
|
31749660 |
2019 |
|
Bacterial Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The aim of this study is to investigate for the first time the relevance of TAS2R38 genetic variants in the susceptibility to bacterial infections associated with in vivo biofilm formation in chronic rhinosinusitis with nasal polyps (CRSwNP) patients.
|
29570813 |
2018 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Strikingly, the glioblastoma growth is significantly attenuated by PTC-209 in a murine orthotopic xenograft model.
|
29886801 |
2018 |
|
Paraneoplastic Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
The clinicopathologic characteristics of CCV-PTC and the paraneoplastic syndromes in follicular cell differentiated thyroid carcinoma were further summarized using literature review.
|
29446856 |
2018 |
|
Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results show that 6-n-propylthiouracil taster status and TAS2R38 locus are associated with PD.
|
29575306 |
2018 |
|
polyps
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Specific T2R38 polymorphisms, correlating with bitter taste sensitivity to phenylthiocarbamide (PTC), have been identified as an independent risk factor for surgical intervention in CRS patients without polyps; however, the exact role of PTC tasting ability in clinical practice remains unknown.
|
29972727 |
2018 |
|
Scoliosis, unspecified
|
0.010 |
Biomarker
|
disease |
BEFREE |
Risser sign, preoperative LC, postoperative RSH, correction rate of PTC at follow-up, correction rate of MTC at follow-up, and LC at follow-up were risk factors for PSI in patients with scoliosis.
|
28889339 |
2018 |
|
Adenocarcinoma, Tubular
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data showed that PTC and TC-CIS were more likely to be smaller in size (<i>P</i>=0.014) and had substantially less nodal involvement (<i>P</i>=0.019), compared with TC-IC.
|
30349383 |
2018 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Strikingly, the glioblastoma growth is significantly attenuated by PTC-209 in a murine orthotopic xenograft model.
|
29886801 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Strikingly, the glioblastoma growth is significantly attenuated by PTC-209 in a murine orthotopic xenograft model.
|
29886801 |
2018 |
|
Epithelial ovarian cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, PTC-028 has the potential to be used as an effective therapeutic agent in patients with epithelial ovarian cancer, where treatment options are limited.<i></i>.
|
29158468 |
2018 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Strikingly, the glioblastoma growth is significantly attenuated by PTC-209 in a murine orthotopic xenograft model.
|
29886801 |
2018 |
|
NEUROTICISM
|
0.010 |
Biomarker
|
disease |
BEFREE |
PTC taste sensitivity did not predict preferences, while Openness to Experience and Neuroticism predicted preference for IDR water.
|
29104107 |
2018 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, our results suggested that the HOXA-AS2/miR-520c-3p/GPC3 axis may play an important role in the regulation of PTC progression, which could serve as a biomarker and therapeutic target for HCC.
|
30415263 |
2018 |
|
Locally Recurrent Malignant Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Locoregional recurrence is common in papillary thyroid cancer PTC and an optimal surgical treatment with respect to the multifocal nature of the disease stays controversial.
|
28550398 |
2018 |
|
Stage 0 Breast Cancer AJCC v6 and v7
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients were categorized into the following three groups: patients with pure TC of the breast (the PTC group), patients with TC and carcinoma in situ of the breast (the TC-CIS group), and patients with TC and other invasive carcinomas of the breast (the TC-IC group).
|
30349383 |
2018 |
|
Chronic rhinosinusitis with nasal polyps
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to investigate for the first time the relevance of TAS2R38 genetic variants in the susceptibility to bacterial infections associated with in vivo biofilm formation in chronic rhinosinusitis with nasal polyps (CRSwNP) patients.
|
29570813 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, PTC-028 has the potential to be used as an effective therapeutic agent in patients with epithelial ovarian cancer, where treatment options are limited.<i></i>.
|
29158468 |
2018 |
|
Metastatic Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TPO (mAb EP159) may be a useful addition to immunohistochemical panels for FNA specimens where metastatic PTC is a consideration, particularly in cases where metastatic lung carcinoma features in the differential diagnosis.
|
29508480 |
2018 |
|
Muscular Dystrophy, Duchenne
|
0.010 |
Biomarker
|
disease |
BEFREE |
McDonald has been a consultant for GSK, Sarepta, PTC Therapeutics, Biomarin, and Catabasis on clinical trials regarding Duchenne muscular dystrophy clinical trial design, endpoint selection, and data analysis; Mitobridge for drug development; and Eli Lilly as part of a steering committee for clinical trials.
|
28530521 |
2017 |