|
Neuromuscular inhibition
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sugammadex (2.0mg/kg at second twitch reappearance [T<sub>2</sub>; moderate NMB], 4.0mg/kg at 1-2 post-tetanic counts [PTC; deep NMB] or 16.0mg/kg at 3min after rocuronium 1.2mg/kg), neostigmine or placebo.
|
28802619 |
2017 |
|
Caffeine related disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Ratings of the bitterness of caffeine and quinine and three other bitter stimuli (urea, propylthiouracil, and denatonium benzoate) were compared with relative taste papilla mRNA abundance of bitter receptors that respond to the corresponding bitter stimuli in cell-based assays ( TAS2R4, TAS2R10, TAS2R38, TAS2R43, and TAS2R46).
|
28118781 |
2017 |
|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
One patient had direct cytological diagnosis of PTC also did not undergo surgical resection/diagnosis due to the advanced primary pancreatic adenocarcinoma.
|
28261999 |
2017 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Therefore, Se-PTC is effective against OUA-induced hyperactivity and alterations in brain oxidative status of rats.
|
28432028 |
2017 |
|
Recurrent upper respiratory tract infection
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in T2R38 functionality has been shown to be associated with susceptibility to upper respiratory tract infections and chronic rhinosinusitis (CRS).
|
28214914 |
2017 |
|
Malignant neoplasm of gastrointestinal tract
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genotyping Analysis of Bitter-Taste Receptor Genes TAS2R38 and TAS2R46 in Japanese Patients with Gastrointestinal Cancers.
|
28552880 |
2017 |
|
Hurthle Cell Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eleven of those (55%) underwent surgical resection with final diagnosis of PTC in 8 cases, follicular carcinoma in one case (5%), follicular adenoma in one case (5%), and Hurthle cell adenoma in one case (5%).
|
28261999 |
2017 |
|
Thyroid Gland Oncocytic Adenoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eleven of those (55%) underwent surgical resection with final diagnosis of PTC in 8 cases, follicular carcinoma in one case (5%), follicular adenoma in one case (5%), and Hurthle cell adenoma in one case (5%).
|
28261999 |
2017 |
|
Alexithymia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings suggest that: 1) alexithymia, in addition to the TAS2R38 polymorphism, may play a role in responsiveness to the aversive and bitter taste of PROP; and 2) alexithymia, in combination with other personality traits, may provide important insights for better understanding food liking.
|
26805725 |
2016 |
|
Anorexia Nervosa
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Current data reinforce the impact of TAS2R38 gene on phenotypic and clinical outputs affecting obesity, showing significant associations with extreme weight conditions (i.e., obesity and anorexia nervosa), and changes in both olfactory capacity and immune traits.
|
27059147 |
2016 |
|
Choroideremia
|
0.010 |
Biomarker
|
disease |
BEFREE |
This comprehensive study on the use of PTC124 and PTC-414 as successful nonsense suppression agents for the treatment of CHM highlights the translational potential of these drugs for inherited retinal disease.
|
27329764 |
2016 |
|
Cystic Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
T2R38 is a bitter taste receptor expressed in the sinonasal tract, and nonfunctional alleles of this receptor have been implicated in treatment-refractory CRS in non-CF patients.
|
26678226 |
2016 |
|
Dental Plaque
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
It can be concluded that variation in CA6 (T55M), DEFB1 (G-20A), and TAS2R38 (A49P) may be associated with caries experience in Turkish adults with a high level of dental plaque, lactobacilli count, and age and when saliva buffer capacity is low.
|
26377569 |
2016 |
|
Malignant neoplasm of stomach
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Findings suggest that TAS2R38 may be associated with the risk for gastric cancer in Koreans, although the TAS2R38 diplotype did not influence dietary intake.
|
27245112 |
2016 |
|
Respiration Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Future studies should focus on understanding the polymorphisms of taste receptors beyond T2R38 to fully elucidate their potential therapeutic use and lay the groundwork for their modulation in a clinical setting to decrease the health impact and economic burden of upper respiratory disease.
|
26731661 |
2016 |
|
Respiratory Tract Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Future studies should focus on understanding the polymorphisms of taste receptors beyond T2R38 to fully elucidate their potential therapeutic use and lay the groundwork for their modulation in a clinical setting to decrease the health impact and economic burden of upper respiratory disease.
|
26731661 |
2016 |
|
Retinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
This comprehensive study on the use of PTC124 and PTC-414 as successful nonsense suppression agents for the treatment of CHM highlights the translational potential of these drugs for inherited retinal disease.
|
27329764 |
2016 |
|
Stomach Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Findings suggest that TAS2R38 may be associated with the risk for gastric cancer in Koreans, although the TAS2R38 diplotype did not influence dietary intake.
|
27245112 |
2016 |
|
Biliary Tract Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that PTC-209 might be a promising drug for future in vitro and in vivo studies in BTC.
|
26623561 |
2016 |
|
Medullary carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
RET/PTC mutations are often discovered both in papillary and in medullary carcinomas, while B-RAF mutation is typical of papillary and anaplastic histologies.
|
25465739 |
2015 |
|
Thyroid Hurthle Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Of 265 TC, 34 (12.8%) harbored TERT promoter mutations, including 10/153 (6.5%) conventional papillary TC (CPTC), 8/57 (14.0%) follicular variant PTC, 9/30 (30%) tall cell variant PTC, 1/3 (30%) Hurthle cell thyroid cancer (HTC), 1/5 (20%) follicular TC, and 5/13 (38.5%) poorly differentiated TC.
|
26354077 |
2015 |
|
Ataxia Telangiectasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We characterized and utilized mouse cell lines derived from PTC and ATC tumors arising in genetically engineered mice with thyroid-specific expression of endogenous Braf(V600E/WT) and deletion of either Trp53 (p53) or Pten.
|
24295207 |
2014 |
|
melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
BRAF(V600E) allele was detected in PTC and melanoma but not in MTC tissues.
|
24858900 |
2014 |
|
Cutaneous Melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study is to describe a case of concurrent medullary and papillary thyroid carcinoma (MTC and PTC) and cutaneous melanoma and to analyze BRAF(V600E) mutation in plasma and tissues.
|
24858900 |
2014 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The decreased MARVELD1 level in lung cancer reduces NMD efficiency through diminishing the association between NMD complex component UPF1/SMG1 and premature termination codons containing mRNA (PTC-mRNA).
|
25520033 |
2014 |