|
Fetal Alcohol Syndrome
|
0.300 |
Biomarker
|
disease |
PSYGENET |
These findings suggest that overexpression of SRF exclusively in astrocytes can improve neuronal plasticity in FASD.
|
22742904 |
2012 |
|
Fetal Alcohol Syndrome
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Overexpression of serum response factor restores ocular dominance plasticity in a model of fetal alcohol spectrum disorders.
|
20164336 |
2010 |
|
HIV Coinfection
|
0.300 |
Biomarker
|
disease |
CTD_human |
Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency.
|
15308739 |
2004 |
|
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
High SRF expressing HCC tissues showed higher levels of expression of MMP-2 and MMP-9, compared with low SRF expressing HCC tissues.
|
21842128 |
2011 |
|
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
There is mounting evidence that MRTFs and SRF represent promising targets for hepatocellular carcinoma (HCC) growth.
|
31844251 |
2020 |
|
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
Depletion of myoferlin in tumour cells from SRF-VP16-derived murine HCCs induced a senescence phenotype.
|
28114277 |
2017 |
|
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
RGD |
SRF may play an important role in the development of hepatocellular carcinoma in LEC rats by mediating the proto-oncogene c-fos induction.
|
9570363 |
1997 |
|
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Co-labeling studies demonstrated exclusive localization of miR-122 in the benign livers, whereas SRF predominantly expressed in HCC.
|
19726678 |
2009 |
|
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
SRF-VP16iHep mHCC reveal convergent Ras/MAPK and Rho/actin signaling as a highly oncogenic driver mechanism for hepatocarcinogenesis.
|
25266280 |
2015 |
|
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Expression of SRF and Snail were detected in 37.6% (55 of 146 cases) and in 12.3% (18 of 146 cases) of the HCCs, respectively.
|
24173109 |
2014 |
|
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
In the HCC cell lines examined, siSRF797 reduced both the mRNA and protein levels of SRF without inducing unspecific interferon response or cytotoxicity.
|
20144681 |
2010 |
|
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
The identification of SRF/MCM7 complex as a target of ATO provides new insights into ATO's mechanism, which may benefit the appropriate use of this agent in the treatment of HCC.
|
31186405 |
2019 |
|
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
The role of serum response factor in hepatocellular carcinoma: implications for disease progression.
|
20811705 |
2010 |
|
Hepatoblastoma
|
0.200 |
Biomarker
|
disease |
RGD |
Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat.
|
9570363 |
1997 |
|
Malignant neoplasm of liver
|
0.200 |
Biomarker
|
disease |
RGD |
Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat.
|
9570363 |
1997 |
|
Hepatoblastoma Caused By Somatic Mutation
|
0.200 |
Biomarker
|
disease |
RGD |
Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat.
|
9570363 |
1997 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor (SRF) that promotes the expression of genes associated with cell proliferation, motility, adhesion, and differentiation-processes that also involve dynamic cytoskeletal changes in the cell.
|
26554816 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we investigated the effects of cAMP-induced cytoskeletal remodelling on the serum response factor (SRF) co-factors Megakaryoblastic Leukemia-1 and -2 (MKL1 and MKL2) and their role in controlling VSMC and EC proliferation and migration.
|
28623279 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1), identified as part of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF).
|
19136660 |
2009 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Active SRF along with its coactivator megakaryoblastic leukemia 1 (MKL1) binds DNA near hedgehog target genes and forms a previously unknown protein complex with the hedgehog transcription factor glioma-associated oncogene family zinc finger-1 (GLI1), causing amplification of GLI1 transcriptional activity.
|
29400712 |
2018 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
TGF-β-induced TNS1 expression is dependent on signaling through the TGF-β receptor 1 and is Rho coiled-coiled kinase/actin/megakaryoblastic leukemia-1/serum response factor dependent.
|
28005397 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, application of dynamic strain or matrix stiffness to 4T1 cells converted the predominant SRF/Mkl1 action into SAP domain-dependent Mkl1 signaling independent of SRF, accompanied by a switch to SAP-dependent tumor cell migration.
|
25999144 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that one of the SRF-regulated neuronal IEGs, activity-regulated cytoskeleton-associated protein (Arc; also termed Arg3.1), is regulated by an SRF coactivator, megakaryoblastic leukemia (MKL).
|
30244496 |
2019 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
TGF-β promoted a delayed nuclear accumulation of the SRF coactivator megakaryoblastic leukemia-1 (MKL1)/myocardin-related transcription factor-A, which was inhibited by latrunculin B.
|
21856814 |
2011 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extracellular signals regulate Srf in part via a pathway involving megakaryoblastic leukemia 1 (Mkl1, also known as myocardin-related transcription factor A [Mrtf-a]), which coactivates Srf-responsive genes downstream of Rho GTPases.
|
16847333 |
2006 |