Abnormal behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Thus, SRF deletion in adult neurons recapitulates some aspects of morphological, electrophysiological, and behavioral changes that are observed in such psychiatric disorders as schizophrenia and autism spectrum disorders.
|
31375980 |
2019 |
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor (SRF) that promotes the expression of genes associated with cell proliferation, motility, adhesion, and differentiation-processes that also involve dynamic cytoskeletal changes in the cell.
|
26554816 |
2015 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we investigated the effects of cAMP-induced cytoskeletal remodelling on the serum response factor (SRF) co-factors Megakaryoblastic Leukemia-1 and -2 (MKL1 and MKL2) and their role in controlling VSMC and EC proliferation and migration.
|
28623279 |
2017 |
Acute Megakaryocytic Leukemias
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1), identified as part of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF).
|
19136660 |
2009 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Active SRF along with its coactivator megakaryoblastic leukemia 1 (MKL1) binds DNA near hedgehog target genes and forms a previously unknown protein complex with the hedgehog transcription factor glioma-associated oncogene family zinc finger-1 (GLI1), causing amplification of GLI1 transcriptional activity.
|
29400712 |
2018 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
TGF-β-induced TNS1 expression is dependent on signaling through the TGF-β receptor 1 and is Rho coiled-coiled kinase/actin/megakaryoblastic leukemia-1/serum response factor dependent.
|
28005397 |
2017 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, application of dynamic strain or matrix stiffness to 4T1 cells converted the predominant SRF/Mkl1 action into SAP domain-dependent Mkl1 signaling independent of SRF, accompanied by a switch to SAP-dependent tumor cell migration.
|
25999144 |
2015 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that one of the SRF-regulated neuronal IEGs, activity-regulated cytoskeleton-associated protein (Arc; also termed Arg3.1), is regulated by an SRF coactivator, megakaryoblastic leukemia (MKL).
|
30244496 |
2019 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
TGF-β promoted a delayed nuclear accumulation of the SRF coactivator megakaryoblastic leukemia-1 (MKL1)/myocardin-related transcription factor-A, which was inhibited by latrunculin B.
|
21856814 |
2011 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extracellular signals regulate Srf in part via a pathway involving megakaryoblastic leukemia 1 (Mkl1, also known as myocardin-related transcription factor A [Mrtf-a]), which coactivates Srf-responsive genes downstream of Rho GTPases.
|
16847333 |
2006 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor and together regulate transcription of actin cytoskeleton genes.
|
31582539 |
2019 |
Acute Megakaryocytic Leukemias
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, we provide initial evidence supporting the ability of Pfn to influence MKL and SRF expression.
|
28546428 |
2017 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lysophosphatidic acid receptors stimulate a Galpha(12/13)/RhoA-dependent gene transcription program involving the serum response factor (SRF) and its coactivator and oncogene, megakaryoblastic leukemia 1 (MKL1).
|
17699722 |
2007 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
The megakaryoblastic leukaemia (MKL) family are serum response factor (SRF) coactivators, which are highly expressed in the brain.
|
29335431 |
2018 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
De novo synthesis of cytoskeleton-regulatory proteins triggered by the megakaryoblastic leukemia (MKL)/serum response factor (SRF) transcriptional system in response to pro-angiogenic growth factors lies at the heart of endothelial cell (EC) migration (a critical element of angiogenesis) and neovascularization.
|
28638990 |
2017 |
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1), also known as MAL or myocardin-related transcription factor A (MRTF-A), is a coactivator of serum response factor, which regulates transcription of actin and actin cytoskeleton-related genes.
|
26224645 |
2015 |
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Western blotting demonstrates that full-length SRF is the predominant form of SRF in rat IEC-6 cells, normal human colonic mucosa, and HT-29 cells, derived from a well-differentiated human colonic adenocarcinoma.
|
15313381 |
2004 |
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
In comclusion, our study suggests that MCM1-10 can serve as diagnostic biomarkers for LUAD patients.
|
31323040 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
In our study, we examined a new therapeutic alternative in the treatment of multiresistant lung adenocarcinoma via siRNA-specific transfection of six crucial molecules involved in lung carcinogenesis [serum response factor(SFR), E2F1, Survivin, hypoxia inducible factor1 (HIF1), HIF2 and signal transducer and activator of transcription (STAT3)].
|
24627437 |
2014 |
Adenomatous goiter
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression level of SRF was significantly up-regulated in PTC (combined staining score of 5.21+/-0.43) and anaplastic carcinoma (5.67+/-1.45) compared to that of follicular adenoma (2.30+/-0.44) (P<0.001), or adenomatous goiter (1.13+/-0.28) (P<0.001).
|
19513551 |
2009 |
Adult Acute Megakaryoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1), identified as part of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF).
|
19136660 |
2009 |
Adult Leiomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Application of the framework to study the differences between gastrointestinal stromal tumor (GIST) and leiomyosarcoma (LMS) resulted in the identification of nine transcription factors (SRF, NKX2-5, CCDC6, LEF1, VDR, ZNF250, TRIM63, MAF, and MYC).
|
21192842 |
2011 |
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, SRF-MYOCD overexpression in small cerebral arteries appears to initiate independently of Abeta a pathogenic pathway mediating arterial hypercontractility and CBF dysregulation, which are associated with Alzheimer's dementia.
|
17215356 |
2007 |
Anaplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Macrophage migration inhibitory factor triggers vascular smooth muscle cell dedifferentiation by a p68-serum response factor axis.
|
28165114 |
2017 |
Anaplastic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SRF was expressed in 50 of 63 cases of papillary carcinoma (79%), 18 of 30 cases of follicular adenoma (60%), 10 of 30 cases of nodular hyperplasia (33%) and 6 of 9 cases of anaplastic carcinoma (67%).
|
19513551 |
2009 |