|
Cardiomyopathy, Dilated
|
0.220 |
Biomarker
|
group |
MGD |
|
|
|
|
Rous Sarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The serum unresponsive Rous sarcoma virus promoter sustains a high serum response factor-dependent transcription in vitro.
|
8240335 |
1993 |
|
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
RGD |
SRF may play an important role in the development of hepatocellular carcinoma in LEC rats by mediating the proto-oncogene c-fos induction.
|
9570363 |
1997 |
|
Liver neoplasms
|
0.200 |
Biomarker
|
group |
RGD |
Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat.
|
9570363 |
1997 |
|
Hepatoblastoma
|
0.200 |
Biomarker
|
disease |
RGD |
Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat.
|
9570363 |
1997 |
|
Malignant neoplasm of liver
|
0.200 |
Biomarker
|
disease |
RGD |
Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat.
|
9570363 |
1997 |
|
Hepatoblastoma Caused By Somatic Mutation
|
0.200 |
Biomarker
|
disease |
RGD |
Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat.
|
9570363 |
1997 |
|
Rheumatoid Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore increased serum response factor activity or failure of Egr-1 repressing signals may account for Egr-1 overexpression in RA synovial fibroblasts.
|
10050673 |
1999 |
|
Epilepsy
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Persistent increased DNA-binding and expression of serum response factor occur with epilepsy-associated long-term plasticity changes.
|
10493724 |
1999 |
|
Status Epilepticus
|
0.020 |
Biomarker
|
disease |
BEFREE |
NMDA receptor activation during SE was required for these changes to take place, and the spontaneous seizures seen in epileptic rats did not appear to be responsible for the increase in SRF.
|
10493724 |
1999 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Overall, these results suggest that the nuclear receptor coactivator ASC-2 also mediates transactivations by SRF, AP-1, and NFkappaB, which may contribute to the putative, ASC-2-mediated tumorigenesis.
|
10847592 |
2000 |
|
Cardiomyopathies
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor.
|
11247792 |
2001 |
|
Heart failure
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that expression of SRF-Delta4,5 in failing hearts may in part contribute to impaired cardiac gene expression and consequently to the pathogenesis of heart failure.
|
11893590 |
2002 |
|
Congestive heart failure
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that expression of SRF-Delta4,5 in failing hearts may in part contribute to impaired cardiac gene expression and consequently to the pathogenesis of heart failure.
|
11893590 |
2002 |
|
Malignant neoplasm of prostate
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neither the R52C nor the S48A substitution affected serum response factor coactivation by NKX3.1 We conclude that the polymorphic NKX3.1 allele codes for a variant protein with altered DNA binding activity that may affect prostate cancer risk.
|
11980664 |
2002 |
|
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neither the R52C nor the S48A substitution affected serum response factor coactivation by NKX3.1 We conclude that the polymorphic NKX3.1 allele codes for a variant protein with altered DNA binding activity that may affect prostate cancer risk.
|
11980664 |
2002 |
|
Lymphangioleiomyomatosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
High SRF level upregulated the expression of matrix metalloproteinase (MMP)-2 and MMP-14, two MMPs previously shown to be increased in LAM.
|
12654640 |
2003 |
|
Lymphangioleiomyomatosis
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Tissue inhibitor of metalloproteinase-3 downregulation in lymphangioleiomyomatosis: potential consequence of abnormal serum response factor expression.
|
12654640 |
2003 |
|
Heart failure
|
0.050 |
Biomarker
|
disease |
BEFREE |
Caspase 3 activation in heart failure sequentially cleaved SRF and generated a dominant-negative transcription factor, which may explain the depression of cardiac-specific genes.
|
12874181 |
2003 |
|
Congestive heart failure
|
0.050 |
Biomarker
|
disease |
BEFREE |
Caspase 3 activation in heart failure sequentially cleaved SRF and generated a dominant-negative transcription factor, which may explain the depression of cardiac-specific genes.
|
12874181 |
2003 |
|
End stage cardiac failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined SRF protein levels from cardiac samples taken at the time of transplantation in 13 patients with end-stage heart failure and 7 normal hearts.
|
12874181 |
2003 |
|
Heart failure
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
A possible dual consequence of increased myocardin and decreased HOP expression levels on serum response factor-dependent cardiac-specific expression in the normal heart and at heart failure is discussed.
|
12920479 |
2003 |
|
Congestive heart failure
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
A possible dual consequence of increased myocardin and decreased HOP expression levels on serum response factor-dependent cardiac-specific expression in the normal heart and at heart failure is discussed.
|
12920479 |
2003 |
|
Gastric ulcer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Injection of SRF antisense expression plasmid into gastric ulcers in rats significantly inhibited in vivo angiogenesis in granulation tissue.
|
15180964 |
2004 |
|
HIV Infections
|
0.300 |
Biomarker
|
group |
CTD_human |
Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency.
|
15308739 |
2004 |