|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Recent studies have indicated that SRF plays a role in the development of some tumors, including hepatocellular, thyroid, esophageal, and lung carcinomas.
|
23134219 |
2013 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression of SRF or Igf1R partially reversed tumor suppressor function of miR-122.
|
19726678 |
2009 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Binding of LNC CRYBG3 to G-actin blocked nuclear localization of MAL, which consequently kept serum response factor (SRF) away from the promoter region of several immediate early genes, including JUNB and Arp3, which are necessary for cellular proliferation, tumor growth, adhesion, movement, and metastasis.
|
29934435 |
2018 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In addition, miR-101-3p could directly target and suppress the expression of the serum response factor (SRF) gene, which is a transcription factor of HOTAIR, a well-characterized tumor promoter lncRNA. miR-101-3p negatively regulated SRF-mediated transcription of HOTAIR.
|
28251884 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
We defined a new role of SRF as a nuclear repressor of the tumor growth factor beta1 (TGF-beta1) growth-inhibitory signal during cell proliferation.
|
16819512 |
2007 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
SRF expression correlated with the tumor size of the PTCs (P<0.05).
|
19513551 |
2009 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
FA-modified albumin nanoparticles are good carriers for delivering SRF to the tumor tissue, which can improve the therapeutic effect and reduce the side effects of the drug.
|
30744448 |
2019 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A fusion between SRF exon 4 and ICA1L exon 10 or 11 was identified in a total of 4 spindle cell tumors with similar clinicopathologic features.
|
31478943 |
2020 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This results in enhanced SRF-dependent transcriptional activity and promotes tumor cell growth and invasion.
|
30371874 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In vivo anticancer analysis results clearly suggest that nanoparticle encapsulation of combination of SRF and miRNA (with miRNA) will have greater antitumor efficacy in tumor mice.
|
29181687 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Depletion of myoferlin in tumour cells from SRF-VP16-derived murine HCCs induced a senescence phenotype.
|
28114277 |
2017 |
|
Malignant Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
Consistent with its role as a Rho/SRF pathway inhibitor, CCG-1423 displays activity in several in vitro cancer cell functional assays.
|
17699722 |
2007 |
|
Malignant Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
We show that the MRTF-SRF pathway is activated in cancer-associated fibroblasts (CAFs).
|
29317486 |
2017 |
|
Malignant Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
Analysis of the immunohistochemical staining of benign versus cancer cores showed higher expression of nuclear SRF protein expression in cancer cores compared with benign for all the three TMAs analysed (P < 0.001, n = 615).
|
29608018 |
2018 |
|
Malignant Neoplasms
|
0.380 |
Biomarker
|
group |
BEFREE |
This is the first study to document a change in expression of the alternatively spliced isoform of SRF in human malignancy.
|
15313381 |
2004 |
|
Malignant Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
MKL1 and SRF were further demonstrated to promote the expression of <i>IL11</i>, which is essential for miR-206's function in inhibiting both invasion and stemness of breast cancer.<b>Conclusions:</b> The identification of the miR-206/TWF1/MKL1-SRF/IL11 signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis.<i>Clin Cancer Res; 23(4); 1091-103.©2016 AACR</i>.
|
27435395 |
2017 |
|
Malignant Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
The majority of these SRF/IGF2BP1-enhanced genes, including PDLIM7 and FOXK1, show conserved upregulation with SRF and IGF2BP1 synthesis in cancer.
|
30371874 |
2019 |
|
Malignant Neoplasms
|
0.380 |
Biomarker
|
group |
BEFREE |
We discovered a breast cancer-specific set of genes including tenascin-C, which is regulated by Mkl1 in a SAP domain-dependent, serum response factor-independent manner and is strongly implicated in cell proliferation, cell motility and cancer.
|
24495796 |
2014 |
|
Malignant Neoplasms
|
0.380 |
Biomarker
|
group |
BEFREE |
MRTF-A, co-activators of serum response factor (SRF), promoted tumor cell invasion and metastasis in cancer.
|
28035058 |
2017 |
|
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
High SRF expressing HCC tissues showed higher levels of expression of MMP-2 and MMP-9, compared with low SRF expressing HCC tissues.
|
21842128 |
2011 |
|
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
There is mounting evidence that MRTFs and SRF represent promising targets for hepatocellular carcinoma (HCC) growth.
|
31844251 |
2020 |
|
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
Depletion of myoferlin in tumour cells from SRF-VP16-derived murine HCCs induced a senescence phenotype.
|
28114277 |
2017 |
|
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Co-labeling studies demonstrated exclusive localization of miR-122 in the benign livers, whereas SRF predominantly expressed in HCC.
|
19726678 |
2009 |
|
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
SRF-VP16iHep mHCC reveal convergent Ras/MAPK and Rho/actin signaling as a highly oncogenic driver mechanism for hepatocarcinogenesis.
|
25266280 |
2015 |
|
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Expression of SRF and Snail were detected in 37.6% (55 of 146 cases) and in 12.3% (18 of 146 cases) of the HCCs, respectively.
|
24173109 |
2014 |