|
Skin lesion
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Individuals with GA/AA (-308 TNF-α) and TA/AA (-3575 IL10) genotypes were at higher risk of developing arsenic-induced skin lesions, ocular, and respiratory diseases.
|
21357384 |
2011 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Kaempferol reduced CD3<sup>+</sup> T cell infiltration and gene expression of major proinflammatory cytokines, including interleukin (IL)-6, IL-17A and tumor necrosis factor (TNF)-α, in the psoriatic skin lesion.
|
31407330 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to investigate the anti-atopic effects of UMB on 2,4-dinitrochlorobenzene (DNCB)- and house dust mite extract (Dermatophagoides farinae extract, DFE)-treated mice with AD-like skin lesions and on tumor necrosis factor (TNF)-α/interferon (IFN)-γ-treated HaCaT cells.
|
31437788 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of TNF-α in palmoplantar pustulosis increased after anti-TNF-α therapy in the two examined patients with exacerbated skin lesions.
|
29611085 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, Tnf gene deficiency prevented skin lesions in cpdm mice.
|
21455173 |
2011 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Treatment of K5.Stat3C mice with TNF-α or EGFR inhibitors attenuated the skin lesions, suggesting the roles of TACE substrates in psoriasis.
|
25384035 |
2014 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
This study has the aim to identify early critical events for the resolution of inflammation in skin lesions using anti-TNF therapy.
|
23731727 |
2013 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
It was found that genistein can significantly improve IMQ-induced pathological scores of cutaneous skin lesions in mice, reduce epidermal thickness, and inhibit the expression of inflammatory factors，including interleukin (IL)-1β, IL-6, tumour necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2), IL-17 and IL-23.
|
30743203 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
After 1 year's treatment, the skin lesions exhibited a reduction in granulomas, and a concomitant reduction in deposits of TNF-alpha.
|
9115924 |
1997 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Oral administration of L. chungangensis CAU 28(T) suppressed the production of IL-4, IL-5, IL-12, IFN-γ, tumor necrosis factor-α, and thymus- and activation-regulated chemokine (TARC) in skin lesions, indicating that it strongly drives the local immune system with efficacy comparable to that of tacrolimus, a topical immunomodulatory drug used for the treatment of atopic dermatitis.
|
27289147 |
2016 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
CRT effectively mitigated the secretion of pro‑inflammatory cytokines, including tumor necrosis factor‑α and interleukin 1β, as well as immune cell infiltration into skin lesions in a mouse model of AD‑like skin disease induced by dinitrochlorobenzene.
|
29845271 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
After 1 month of prednisolone treatment the sizes of the skin granulomas were reduced, as were the grades of cells positive for TNF-alpha and IL-10 in skin lesions.
|
15908402 |
2005 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, the anti‑AD effects of a 70% ethanol extract of TAEE were investigated in 2,4‑dinitrochlorobenzene (DNCB)‑treated mice with AD‑like skin lesions and in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated human keratinocytes (HaCaT cells).
|
30066901 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, C5aR1 deficiency significantly decreased IMQ-induced infiltration of plasmacytoid dendritic cells (pDCs), monocytes and neutrophils in psoriatic skin lesions and functions of pDCs, evidenced by the remarkable reduction in the IMQ-induced production of interferon-α (IFN-α) and tumor necrosis factor α (TNF-α), and FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent pDCs differentiation.
|
31447855 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Treatment with antibody to TNF-alpha prevented death, resulted in near normal growth, and produced a marked decrease in skin lesions and a profound reduction in the expression of HIV-1 mRNA and gp120.
|
12388730 |
2002 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
ASC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor-α (TNF-α) in AD skin lesions of Nc/Nga mice.
|
29996938 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
BS significantly reduced the protein and mRNA expression of TSLP, IL-6, and tumor necrosis factor-α in the AD skin lesions.
|
29455734 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
The prevalence of immunoreactant deposits in the skin lesions measured by DIF was 54.7% (35 of 64 patients).
|
19839494 |
2009 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics.
|
29143979 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor inhibitors decrease the risk of cardiovascular events in moderate to severe psoriasis, but the association between their effects on endothelial function and those on skin lesions has not been well studied.
|
30168849 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Upregulation and nuclear localization of TNF-like cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesions.
|
21672030 |
2011 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
We analyzed the presence of M4 macrophage markers (CD68, MRP8, MMP7, IL-6, and TNF-α) in 33 leprosy skin lesion samples from 18 patients with tuberculoid leprosy and 15 with lepromatous leprosy by immunohistochemistry.
|
30442123 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously identified 6-sulfo LacNAc-expressing monocytes (slanMo) as TNF-α- and IL-23-producing cells in psoriatic skin lesions and as inducers of IFN-γ-, IL-17-, and IL-22-producing T cells.
|
29977237 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
CCL27 may act early in the course of disease, via the circulation, whereas TNF-α acts throughout the course of disease, in skin lesions.
|
29713456 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Ethanolic Extracts of <i>Artemisia apiacea</i> Hance Improved Atopic Dermatitis-Like Skin Lesions In Vivo and Suppressed TNF-Alpha/IFN-Gamma⁻Induced Proinflammatory Chemokine Production In Vitro.
|
29932162 |
2018 |