|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor inhibitors decrease the risk of cardiovascular events in moderate to severe psoriasis, but the association between their effects on endothelial function and those on skin lesions has not been well studied.
|
30168849 |
2019 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Administration of CK onto DNCB-induced AD-like skin lesions in NC/Nga mice ameliorated lesion intensity scores, levels of IgE, thymus and activation-regulated chemokine (TARC), TNF-α, and IL-4 in serum and ears.
|
22407167 |
2012 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
After 1 month of prednisolone treatment the sizes of the skin granulomas were reduced, as were the grades of cells positive for TNF-alpha and IL-10 in skin lesions.
|
15908402 |
2005 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
After 1 year's treatment, the skin lesions exhibited a reduction in granulomas, and a concomitant reduction in deposits of TNF-alpha.
|
9115924 |
1997 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics.
|
29143979 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
ASC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor-α (TNF-α) in AD skin lesions of Nc/Nga mice.
|
29996938 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Assessment of the concentration of the proinflammatory cytokines (IL-12, IL-23, IL-17 and TNF-α) in blood serum and their correlation with the intensity of skin lesions, the presence of psoriatic arthritis and the risk of development of obesity and metabolic syndrome.
|
30206447 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
BS significantly reduced the protein and mRNA expression of TSLP, IL-6, and tumor necrosis factor-α in the AD skin lesions.
|
29455734 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
CCL27 may act early in the course of disease, via the circulation, whereas TNF-α acts throughout the course of disease, in skin lesions.
|
29713456 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
CRT effectively mitigated the secretion of pro‑inflammatory cytokines, including tumor necrosis factor‑α and interleukin 1β, as well as immune cell infiltration into skin lesions in a mouse model of AD‑like skin disease induced by dinitrochlorobenzene.
|
29845271 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-α/IFN-γ-induced TARC activation in HaCaT cells.
|
23454147 |
2013 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Ethanolic Extracts of <i>Artemisia apiacea</i> Hance Improved Atopic Dermatitis-Like Skin Lesions In Vivo and Suppressed TNF-Alpha/IFN-Gamma⁻Induced Proinflammatory Chemokine Production In Vitro.
|
29932162 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of TNF-α in palmoplantar pustulosis increased after anti-TNF-α therapy in the two examined patients with exacerbated skin lesions.
|
29611085 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
High concentrations of tumor necrosis factor-alpha (TNFα) are found in the skin lesions and plasma of patients with psoriasis.
|
28272075 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
High levels of interleukin (IL)-1beta, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma have been detected in skin lesions or sera of patients with BP.
|
16403098 |
2006 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, Tnf gene deficiency prevented skin lesions in cpdm mice.
|
21455173 |
2011 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, Cal/BDP significantly suppressed the interleukin (IL)-23/IL-17-producing T (T17) pathogenic axis, including expression of IL-17a, IL-23a, IL-22 and TNF-α mRNA in skin lesions and expansion of CCR6<sup>+</sup> γδ T17 cells in the draining lymph nodes.
|
31705000 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, the anti‑AD effects of a 70% ethanol extract of TAEE were investigated in 2,4‑dinitrochlorobenzene (DNCB)‑treated mice with AD‑like skin lesions and in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated human keratinocytes (HaCaT cells).
|
30066901 |
2018 |
|
Skin lesion
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Individuals with GA/AA (-308 TNF-α) and TA/AA (-3575 IL10) genotypes were at higher risk of developing arsenic-induced skin lesions, ocular, and respiratory diseases.
|
21357384 |
2011 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
It was found that genistein can significantly improve IMQ-induced pathological scores of cutaneous skin lesions in mice, reduce epidermal thickness, and inhibit the expression of inflammatory factors，including interleukin (IL)-1β, IL-6, tumour necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2), IL-17 and IL-23.
|
30743203 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Kaempferol reduced CD3<sup>+</sup> T cell infiltration and gene expression of major proinflammatory cytokines, including interleukin (IL)-6, IL-17A and tumor necrosis factor (TNF)-α, in the psoriatic skin lesion.
|
31407330 |
2019 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lesion size reduction was associated with reduced expression of IRS-1 (P < 0.01), TNFα (P < 0.0001), and vascular endothelial growth factor (P < 0.01); reduced keratinocyte proliferation (P < 0.01); and the restoration (P < 0.02) of normal levels of infiltrating CD4(+) and CD3(+) lymphocytes in psoriatic skin lesions.
|
24504098 |
2014 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Macroscopic and microscopic evaluation of skin lesions was performed together with measurements of serum levels of interleukin (IL)-1β, IL-6, tumour necrosis factor alpha (TNF-α), IL-17, IL-22, IL-10 and IL-4.
|
29409331 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, C5aR1 deficiency significantly decreased IMQ-induced infiltration of plasmacytoid dendritic cells (pDCs), monocytes and neutrophils in psoriatic skin lesions and functions of pDCs, evidenced by the remarkable reduction in the IMQ-induced production of interferon-α (IFN-α) and tumor necrosis factor α (TNF-α), and FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent pDCs differentiation.
|
31447855 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Neutralization of tumor necrosis factor-α and IL-6 (both downstream of IL-17A) reduced skin lesions, attenuated oxidative stress in heart and blood, and partially improved endothelial dysfunction in K14-IL-17A(ind/+) mice.
|
25341795 |
2014 |