|
Myocardial Infarction
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.
|
24916648 |
2015 |
|
Myocardial Infarction
|
0.450 |
Biomarker
|
disease |
BEFREE |
BRCA-1 associated protein (BRAP), a newly identified risk gene for MI, aggravates the inflammatory response in atherosclerosis.
|
23356535 |
2013 |
|
Myocardial Infarction
|
0.450 |
Biomarker
|
disease |
BEFREE |
The BRCA-1 associated protein gene (BRAP) was recently identified as a susceptibility gene for myocardial infarction (MI).
|
21670849 |
2012 |
|
Myocardial Infarction
|
0.450 |
Biomarker
|
disease |
CTD_human |
We report an association of SNPs in BRAP with myocardial infarction risk in a large Japanese cohort (P = 3.0 x 10(-18), OR = 1.48, 2,475 cases and 2,778 controls), with replication in additional Japanese and Taiwanese cohorts (P = 4.4 x 10(-6), 862 cases and 1,113 controls and P = 4.7 x 10(-3), 349 cases and 994 controls, respectively).
|
19198608 |
2009 |
|
Myocardial Infarction
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese.
|
24916648 |
2015 |
|
Myocardial Infarction
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism (SNP) rs11066001 of BRAP has been shown to be associated with myocardial infarction (MI), coronary atherosclerosis and carotid atherosclerosis, but it is not clear whether it also plays a role in peripheral artery disease (PAD).
|
21301165 |
2011 |
|
Myocardial Infarction
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
We previously reported that a single nucleotide polymorphism (rs11066001) in the BRAP gene was related to the risk of myocardial infarction.
|
22085839 |
2011 |
|
Myocardial Infarction
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population.
|
21107343 |
2011 |
|
Myocardial Infarction
|
0.450 |
Biomarker
|
disease |
BEFREE |
We report an association of SNPs in BRAP with myocardial infarction risk in a large Japanese cohort (P = 3.0 x 10(-18), OR = 1.48, 2,475 cases and 2,778 controls), with replication in additional Japanese and Taiwanese cohorts (P = 4.4 x 10(-6), 862 cases and 1,113 controls and P = 4.7 x 10(-3), 349 cases and 994 controls, respectively).
|
19198608 |
2009 |
|
Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the BRAP gene may confer vulnerability for SZ in Han Chinese population, adding further evidence for the involvement of developmental and/or neuroinflammatory cascades in the illness.
|
24454952 |
2014 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Our data suggest that the BRAP gene may confer vulnerability for SZ in Han Chinese population, adding further evidence for the involvement of developmental and/or neuroinflammatory cascades in the illness.
|
24454952 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.120 |
Biomarker
|
disease |
BEFREE |
Results suggested that (i) parental risk factors, such as parental alcohol dependence and regular smoking, increase risk for externalizing behavior; (ii) prenatal exposures predicted increased symptomatology for HYP/IMP (smoking during pregnancy), INATT and CDP (prenatal alcohol exposure); (iii) after adjusting for measured familial/prenatal risk factors, genetic influences were significant for HYP/IMP, INATT, and CDP; however, similar to earlier reports, genetic effects on alcohol dependence symptoms were negligible; and (iv) in adolescence, correlated liabilities for conduct and alcohol problems are found in environmental factors common to both phenotypes, while covariation among impulsivity, inattention, and conduct problems is primarily due to genetic influences common to these three behaviors.
|
19341765 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
In the present case-control analysis, <i>BRAP rs3782886</i> showed the most significant association signal with a risk of AD (<i>P</i>=1.29×10<sup>-16</sup>, <i>P<sub>corr</sub></i> =7.74×10<sup>-16</sup>, OR =0.19).
|
30636874 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison.
|
31591379 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
"ALDH2 is associated to alcohol dependence and is the major genetic determinant of ""daily maximum drinks"" in a GWAS study of an isolated rural Chinese sample."
|
24277619 |
2014 |
|
Coronary heart disease
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of coronary artery disease in the Japanese.
|
21971053 |
2012 |
|
Coronary heart disease
|
0.120 |
Biomarker
|
disease |
BEFREE |
Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease.
|
19713974 |
2009 |
|
Coronary heart disease
|
0.120 |
Biomarker
|
disease |
BEFREE |
The single nucleotide polymorphisms (SNPs) in the gene of breast cancer suppressor protein (BRCA1)-associated protein (BRAP) are significantly associated with coronary artery disease, but the molecular mechanisms are not understood.
|
22965072 |
2013 |
|
Coronary heart disease
|
0.120 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of a coronary artery disease risk variant.
|
23364394 |
2013 |
|
Drinking behavior processes
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.
|
21372407 |
2011 |
|
Drinking behavior processes
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Common variants at 12q24 are associated with drinking behavior in Han Chinese.
|
23364009 |
2013 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
Malignant neoplasm of esophagus
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
|
21642993 |
2011 |
|
Coronary Arteriosclerosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism (SNP) rs11066001 of BRAP has been shown to be associated with myocardial infarction (MI), coronary atherosclerosis and carotid atherosclerosis, but it is not clear whether it also plays a role in peripheral artery disease (PAD).
|
21301165 |
2011 |
|
Coronary Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
The single nucleotide polymorphisms (SNPs) in the gene of breast cancer suppressor protein (BRCA1)-associated protein (BRAP) are significantly associated with coronary artery disease, but the molecular mechanisms are not understood.
|
22965072 |
2013 |