|
Blast Phase
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The decrease in IMP DH activity, GTP concentration, and expression of c-Ki-ras oncogene were early markers of the successful chemotherapeutic impact of tiazofurin in a patient with chronic granulocytic leukemia in blast crisis.
|
1705812 |
1991 |
|
Myeloid Leukemia, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The decrease in IMP DH activity, GTP concentration, and expression of c-Ki-ras oncogene were early markers of the successful chemotherapeutic impact of tiazofurin in a patient with chronic granulocytic leukemia in blast crisis.
|
1705812 |
1991 |
|
Blast Phase
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Tiazofurin effects on IMP-dehydrogenase activity and expression in the leukemia cells of patients with CML blast crisis.
|
9042310 |
1997 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since IMP has been proposed to be the potential target of lithium, a drug commonly used for the treatment of bipolar disorder, we proceeded to characterize the cognate transcript.
|
9322233 |
1997 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The BRCA1-associated protein BARD1 is a putative tumor suppressor.
|
11779501 |
2001 |
|
Pseudomonas Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Successful carbapenem-based chemotherapy for the treatment of Pseudomonas infections has been seriously hindered by the recent appearance of IMP- and VIM-type metallo-beta-lactamases, which confer high-level resistance to carbapenems and most other beta-lactams.
|
12409373 |
2002 |
|
Glycogen Storage Disease Type VII
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Exposure to a calmodulin antagonist significantly slows IMP accumulation during experimental energy imbalance in patients' cells to levels that are similar to those in untreated controls, implying that Ca2+-calmodulin is involved in erythrocyte AMP deaminase activation in familial phosphofructokinase deficiency.
|
16670071 |
2006 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Recent studies identified IMP proteins as oncofetal factors in various neoplasias, but knowledge of a potential role in ovarian carcinomas is still lacking.
|
17546046 |
2007 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent studies identified IMP proteins as oncofetal factors in various neoplasias, but knowledge of a potential role in ovarian carcinomas is still lacking.
|
17546046 |
2007 |
|
Retinitis Pigmentosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
IMP dehydrogenase-linked retinitis pigmentosa.
|
18600550 |
2008 |
|
Myocardial Infarction
|
0.450 |
Biomarker
|
disease |
CTD_human |
We report an association of SNPs in BRAP with myocardial infarction risk in a large Japanese cohort (P = 3.0 x 10(-18), OR = 1.48, 2,475 cases and 2,778 controls), with replication in additional Japanese and Taiwanese cohorts (P = 4.4 x 10(-6), 862 cases and 1,113 controls and P = 4.7 x 10(-3), 349 cases and 994 controls, respectively).
|
19198608 |
2009 |
|
Myocardial Infarction
|
0.450 |
Biomarker
|
disease |
BEFREE |
We report an association of SNPs in BRAP with myocardial infarction risk in a large Japanese cohort (P = 3.0 x 10(-18), OR = 1.48, 2,475 cases and 2,778 controls), with replication in additional Japanese and Taiwanese cohorts (P = 4.4 x 10(-6), 862 cases and 1,113 controls and P = 4.7 x 10(-3), 349 cases and 994 controls, respectively).
|
19198608 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.120 |
Biomarker
|
disease |
BEFREE |
Results suggested that (i) parental risk factors, such as parental alcohol dependence and regular smoking, increase risk for externalizing behavior; (ii) prenatal exposures predicted increased symptomatology for HYP/IMP (smoking during pregnancy), INATT and CDP (prenatal alcohol exposure); (iii) after adjusting for measured familial/prenatal risk factors, genetic influences were significant for HYP/IMP, INATT, and CDP; however, similar to earlier reports, genetic effects on alcohol dependence symptoms were negligible; and (iv) in adolescence, correlated liabilities for conduct and alcohol problems are found in environmental factors common to both phenotypes, while covariation among impulsivity, inattention, and conduct problems is primarily due to genetic influences common to these three behaviors.
|
19341765 |
2009 |
|
Impulsive Behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Results suggested that (i) parental risk factors, such as parental alcohol dependence and regular smoking, increase risk for externalizing behavior; (ii) prenatal exposures predicted increased symptomatology for HYP/IMP (smoking during pregnancy), INATT and CDP (prenatal alcohol exposure); (iii) after adjusting for measured familial/prenatal risk factors, genetic influences were significant for HYP/IMP, INATT, and CDP; however, similar to earlier reports, genetic effects on alcohol dependence symptoms were negligible; and (iv) in adolescence, correlated liabilities for conduct and alcohol problems are found in environmental factors common to both phenotypes, while covariation among impulsivity, inattention, and conduct problems is primarily due to genetic influences common to these three behaviors.
|
19341765 |
2009 |
|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus, while a variety of adolescent problem behaviors are significantly correlated, the structure of that association may differ as a function of phenotype (e.g., comorbid HYP/IMP and CDP vs. comorbid CDP and AlcProb), a finding that could inform different approaches to treatment and prevention.
|
19341765 |
2009 |
|
Alcohol problem
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus, while a variety of adolescent problem behaviors are significantly correlated, the structure of that association may differ as a function of phenotype (e.g., comorbid HYP/IMP and CDP vs. comorbid CDP and AlcProb), a finding that could inform different approaches to treatment and prevention.
|
19341765 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
This review provides a background to the IMP protein family with an emphasis on human IMP2, followed by a closer look at the GWA studies to evaluate the significance, if any, of the proposed correlation between IMP2 and T2D.
|
19429674 |
2009 |
|
Coronary heart disease
|
0.120 |
Biomarker
|
disease |
BEFREE |
Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease.
|
19713974 |
2009 |
|
Coronary Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease.
|
19713974 |
2009 |
|
Coronary Artery Disease
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In addition, a combined analysis of BRAP and another CAD locus on 9p21 suggested that these loci had a synergistic role in the susceptibility.
|
19713974 |
2009 |
|
Alanine aminotransferase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of hematological and biochemical traits in a Japanese population.
|
20139978 |
2010 |
|
Serum Alanine Aminotransferase Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study of hematological and biochemical traits in a Japanese population.
|
20139978 |
2010 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
PET of (124)I-IMP-R4-ch806 biodistribution was able to clearly detect the U87MG.de2-7 tumors at 24 h after injection and for at least 168 h after injection.
|
20484439 |
2010 |
|
Glioma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Immuno-PET quantitation of de2-7 epidermal growth factor receptor expression in glioma using 124I-IMP-R4-labeled antibody ch806.
|
20484439 |
2010 |
|
Fanconi Anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
BRIP1 is a BRCA1 associated protein that is mutated in a fraction of familial breast cancer and Fanconi anemia cases.
|
20567916 |
2010 |