|
Myocardial Infarction
|
0.450 |
Biomarker
|
disease |
BEFREE |
BRCA-1 associated protein (BRAP), a newly identified risk gene for MI, aggravates the inflammatory response in atherosclerosis.
|
23356535 |
2013 |
|
Myocardial Infarction
|
0.450 |
Biomarker
|
disease |
BEFREE |
The BRCA-1 associated protein gene (BRAP) was recently identified as a susceptibility gene for myocardial infarction (MI).
|
21670849 |
2012 |
|
Myocardial Infarction
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism (SNP) rs11066001 of BRAP has been shown to be associated with myocardial infarction (MI), coronary atherosclerosis and carotid atherosclerosis, but it is not clear whether it also plays a role in peripheral artery disease (PAD).
|
21301165 |
2011 |
|
Myocardial Infarction
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
We previously reported that a single nucleotide polymorphism (rs11066001) in the BRAP gene was related to the risk of myocardial infarction.
|
22085839 |
2011 |
|
Myocardial Infarction
|
0.450 |
Biomarker
|
disease |
BEFREE |
We report an association of SNPs in BRAP with myocardial infarction risk in a large Japanese cohort (P = 3.0 x 10(-18), OR = 1.48, 2,475 cases and 2,778 controls), with replication in additional Japanese and Taiwanese cohorts (P = 4.4 x 10(-6), 862 cases and 1,113 controls and P = 4.7 x 10(-3), 349 cases and 994 controls, respectively).
|
19198608 |
2009 |
|
Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the BRAP gene may confer vulnerability for SZ in Han Chinese population, adding further evidence for the involvement of developmental and/or neuroinflammatory cascades in the illness.
|
24454952 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.120 |
Biomarker
|
disease |
BEFREE |
Results suggested that (i) parental risk factors, such as parental alcohol dependence and regular smoking, increase risk for externalizing behavior; (ii) prenatal exposures predicted increased symptomatology for HYP/IMP (smoking during pregnancy), INATT and CDP (prenatal alcohol exposure); (iii) after adjusting for measured familial/prenatal risk factors, genetic influences were significant for HYP/IMP, INATT, and CDP; however, similar to earlier reports, genetic effects on alcohol dependence symptoms were negligible; and (iv) in adolescence, correlated liabilities for conduct and alcohol problems are found in environmental factors common to both phenotypes, while covariation among impulsivity, inattention, and conduct problems is primarily due to genetic influences common to these three behaviors.
|
19341765 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
In the present case-control analysis, <i>BRAP rs3782886</i> showed the most significant association signal with a risk of AD (<i>P</i>=1.29×10<sup>-16</sup>, <i>P<sub>corr</sub></i> =7.74×10<sup>-16</sup>, OR =0.19).
|
30636874 |
2019 |
|
Coronary heart disease
|
0.120 |
Biomarker
|
disease |
BEFREE |
Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease.
|
19713974 |
2009 |
|
Coronary heart disease
|
0.120 |
Biomarker
|
disease |
BEFREE |
The single nucleotide polymorphisms (SNPs) in the gene of breast cancer suppressor protein (BRCA1)-associated protein (BRAP) are significantly associated with coronary artery disease, but the molecular mechanisms are not understood.
|
22965072 |
2013 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The BRCA1-associated protein BARD1 is a putative tumor suppressor.
|
11779501 |
2001 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
PET of (124)I-IMP-R4-ch806 biodistribution was able to clearly detect the U87MG.de2-7 tumors at 24 h after injection and for at least 168 h after injection.
|
20484439 |
2010 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The effects of BRAP expression on tumour cell behaviour in vitro and in an in vivo xenograft mouse model were examined.
|
31776938 |
2020 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Recent studies identified IMP proteins as oncofetal factors in various neoplasias, but knowledge of a potential role in ovarian carcinomas is still lacking.
|
17546046 |
2007 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Although discussed using variable terminology, cutaneous BRCA1-associated protein (BAP1)-inactivated melanocytic tumor (BIMT) has been considered a discrete diagnostic entity since 2011.
|
31233225 |
2019 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
To identify novel NF-pNET-associated antigens, we performed serological identification of antigens by recombinant cDNA expression cloning (SEREX) and identified five tumor antigens (phosphatase and tensin homolog, EP300-interacting inhibitor of differentiation 3 [EID3], EH domain-containing protein 1, galactoside-binding soluble 9, and BRCA1-associated protein).
|
29290942 |
2017 |
|
Coronary Arteriosclerosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism (SNP) rs11066001 of BRAP has been shown to be associated with myocardial infarction (MI), coronary atherosclerosis and carotid atherosclerosis, but it is not clear whether it also plays a role in peripheral artery disease (PAD).
|
21301165 |
2011 |
|
Coronary Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
The single nucleotide polymorphisms (SNPs) in the gene of breast cancer suppressor protein (BRCA1)-associated protein (BRAP) are significantly associated with coronary artery disease, but the molecular mechanisms are not understood.
|
22965072 |
2013 |
|
Coronary Arteriosclerosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The BRAP rs11066001 gene is associated with the extent of coronary atherosclerosis and has a synergistic effect with diabetes on the occurrence of significant CAD in the Chinese population.
|
22085839 |
2011 |
|
Coronary Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease.
|
19713974 |
2009 |
|
Coronary Artery Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
In the replication phase, involving 3052 cases and 6335 controls, 12 SNPs were tested; CAD association was replicated and/or verified for 4 (of 12) SNPs from 3 loci: near BRAP and ALDH2 on 12q24 (P=1.6 × 10(-34)), HLA-DQB1 on 6p21 (P=4.7 × 10(-7)), and CDKN2A/B on 9p21 (P=6.1 × 10(-16)).
|
21971053 |
2012 |
|
Coronary Artery Disease
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In addition, a combined analysis of BRAP and another CAD locus on 9p21 suggested that these loci had a synergistic role in the susceptibility.
|
19713974 |
2009 |
|
Coronary Artery Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
The single nucleotide polymorphisms (SNPs) in the gene of breast cancer suppressor protein (BRCA1)-associated protein (BRAP) are significantly associated with coronary artery disease, but the molecular mechanisms are not understood.
|
22965072 |
2013 |
|
Coronary Artery Disease
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The BRAP rs11066001 gene is associated with the extent of coronary atherosclerosis and has a synergistic effect with diabetes on the occurrence of significant CAD in the Chinese population.
|
22085839 |
2011 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Subsequently, human BRAP has been found to exert multiple functions, many of which are related to cancer development.
|
31776938 |
2020 |