|
Heart Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Individuals in the CNS-IMP cluster were the oldest, with the worst function and more likely to live in a nursing home; those in the HEART cluster had the highest number of co-occurring diseases and drugs, and they exhibited the highest mean values of serum creatinine and C - reactive protein.
|
31125398 |
2020 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In parallel, we found that BRAP knockdown increased tumour growth and invasion and decreased survival in an in vivo glioma xenograft mouse model.
|
31776938 |
2020 |
|
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Effect of dietary energy and polymorphisms in BRAP and GHRL on obesity and metabolic traits.
|
27245511 |
2019 |
|
Uveal melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Uveal melanoma (UM) remains without effective therapy at the metastatic stage, which is associated with <i>BAP-1</i> (BRCA1 associated protein) mutations.
|
31146482 |
2019 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Also, administration with SB or IMP could reverse the hyperactivity of hypothalamic-pituitary-adrenal axis as well as decreased inflammatory cytokines with improved antioxidant status.
|
31353549 |
2019 |
|
Pulmonary arterial hypertension
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Role of BRCA1-associated protein (BRAP) variant in childhood pulmonary arterial hypertension.
|
30703135 |
2019 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Whole-exome next-generation sequencing was performed in the 2 PAH patients and the proband's healthy mother, and a BRCA1-associated protein (BRAP) gene variant, p.Arg554Leu, was identified in the 2 family members with PAH, but not in the proband's mother without PAH.
|
30703135 |
2019 |
|
Anemia, Sickle Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
Regional cerebral blood flow (CBF) were obtained from ASL and <sup>123</sup>I-IMP single-photon emission computed tomography (SPECT) images by volume-of-interest analysis in patients with SCD (n = 16).
|
30216759 |
2018 |
|
Ascites
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Complete Genome Sequence of <i>bla</i><sub>IMP-6</sub>-Positive <i>Metakosakonia</i> sp. MRY16-398 Isolate From the Ascites of a Diverticulitis Patient.
|
30524415 |
2018 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
In colon CA IAI isolates susceptibilities did not reach 80% for AMK and ETP, and in pancreatic IAIs susceptibilities of HA GNBs did not reach 80% to AMK, TZP and ETP, and CA GNBs to IMP and ETP.
|
30453893 |
2018 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Using iodine-123-N-isopropyl-p-iodoamphetamine single-photon emission computed tomography (IMP-SPECT), we performed a cross-sectional study of 44 patients with diabetes, and compared CBF in those with (n = 24) and without neuropathic pain (n = 20).
|
29627772 |
2018 |
|
Personality Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The main difference between groups was ICD-10 diagnosis distribution: in the IMP group more anxiety-related disorders (F4), in the N-IMP group more personality disorders (F6).
|
28826267 |
2018 |
|
Bone marrow depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
All patients receive folic acid 5 mg daily whilst on the trial IMP to reduce the risk of bone marrow depression.
|
29402332 |
2018 |
|
Renal carnitine transport defect
|
0.010 |
Biomarker
|
disease |
BEFREE |
Regional cerebral blood flow (CBF) were obtained from ASL and <sup>123</sup>I-IMP single-photon emission computed tomography (SPECT) images by volume-of-interest analysis in patients with SCD (n = 16).
|
30216759 |
2018 |
|
Intracranial Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Acetazolamide reactivity on <sup>123</sup> I-IMP SPECT is used to detect misery perfusion due to intracranial atherosclerosis.
|
29215168 |
2018 |
|
Abdominal Infection
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In colon CA IAI isolates susceptibilities did not reach 80% for AMK and ETP, and in pancreatic IAIs susceptibilities of HA GNBs did not reach 80% to AMK, TZP and ETP, and CA GNBs to IMP and ETP.
|
30453893 |
2018 |
|
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
This work characterized mega plasmid pSY153-MDR, carrying <i>bla</i><sub>IMP-45</sub> and <i>armA</i>, from a multidrug-resistant (MDR) <i>Pseudomonas putida</i> isolate from the urine of a cerebral infarction patient in China.
|
28978128 |
2017 |
|
Muscle Rigidity
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Mutations in the BRCA1-associated protein required for the ataxia telangiectasia mutated (ATM) activation-1 (BRAT1) gene cause lethal neonatal rigidity and multifocal seizure syndrome characterized by rigidity and intractable seizures and a milder phenotype with intellectual disability, seizures, nonprogressive cerebellar ataxia or dyspraxia, and cerebellar atrophy.
|
28635423 |
2017 |
|
Seizures
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Mutations in the BRCA1-associated protein required for the ataxia telangiectasia mutated (ATM) activation-1 (BRAT1) gene cause lethal neonatal rigidity and multifocal seizure syndrome characterized by rigidity and intractable seizures and a milder phenotype with intellectual disability, seizures, nonprogressive cerebellar ataxia or dyspraxia, and cerebellar atrophy.
|
28635423 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In patient tumors, 90% of ESCCs examined had higher levels of BRAP protein than paired non-tumor tissues, and 63.8% had gains in BRAP DNA copy number.
|
28780075 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> Clear cell renal cell carcinoma (ccRCC) is the most prevalent histologic subtype of kidney cancers in adults, which could be divided into two distinct subgroups according to the <i>BRCA1 associated protein-1</i> (<i>BAP1</i>) mutation status.
|
28900502 |
2017 |
|
Cerebellar atrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the BRCA1-associated protein required for the ataxia telangiectasia mutated (ATM) activation-1 (BRAT1) gene cause lethal neonatal rigidity and multifocal seizure syndrome characterized by rigidity and intractable seizures and a milder phenotype with intellectual disability, seizures, nonprogressive cerebellar ataxia or dyspraxia, and cerebellar atrophy.
|
28635423 |
2017 |
|
Malignant neoplasm of kidney
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> Clear cell renal cell carcinoma (ccRCC) is the most prevalent histologic subtype of kidney cancers in adults, which could be divided into two distinct subgroups according to the <i>BRCA1 associated protein-1</i> (<i>BAP1</i>) mutation status.
|
28900502 |
2017 |
|
Chronic Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
After adjustment for clinical factors, kidney function was associated with BRAP rs3782886 and SPATA5L1 rs2467853 and the GRS for CKD that we developed was associated CKD.
|
29016630 |
2017 |
|
RIGIDITY AND MULTIFOCAL SEIZURE SYNDROME, LETHAL NEONATAL
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the BRCA1-associated protein required for the ataxia telangiectasia mutated (ATM) activation-1 (BRAT1) gene cause lethal neonatal rigidity and multifocal seizure syndrome characterized by rigidity and intractable seizures and a milder phenotype with intellectual disability, seizures, nonprogressive cerebellar ataxia or dyspraxia, and cerebellar atrophy.
|
28635423 |
2017 |