Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
CDH1 hypermethylation status was found to be associated with advancement of disease, distant organ metastases and lymph node invasion in Gastric cancer patients.
|
30989488 |
2019 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
E-cadherin gene mutations have previously been detected in advanced diffuse-type gastric cancer and gastric carcinoma cell lines.
|
8973475 |
1996 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied.
|
22936446 |
2012 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis of CDH1 C-160A genetic polymorphism and gastric cancer risk.
|
21612411 |
2011 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy.
|
22543498 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population.
|
18482459 |
2008 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism at position -160 at the CDH1 promoter region has been reported to lead to transcriptional downregulation of the gene in vitro, with possible increase in the risk of gastric cancer.
|
17549573 |
2007 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in the E-cadherin gene promoter-160 is not associated with risk of Korean gastric cancer.
|
12923325 |
2003 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A very small proportion of GCs can be caused by a specific germ-line mutation of the E-cadherin gene (CDH1).
|
22104201 |
2011 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
All individuals with a CDH1 mutation had a personal or family history of diffuse gastric cancer.
|
26072394 |
2015 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Among these genes, the mRNA ratio of CDH2 to CDH1 could distinguish the 15 diffuse-type GC samples from the 17 intestinal-type GC samples.
|
24728500 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An overview of the various pathways of importance in gastric cancer, as discovered through in-vitro, primary cancer and mouse model studies, is presented and the clinical importance of CDH1 mutations is discussed.
|
17311530 |
2007 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Analysis of HDGC patients harbouring CDH1 alleles with PTCs at a wide variety of different positions indicates an association of their predicted ability to induce NMD and an earlier age of onset of gastric cancer.
|
18427545 |
2008 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer.
|
12444556 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Carriers of CDH1 mutations are at risk for a highly penetrant, aggressive and early-onset diffuse-type gastric cancer, and these individuals are usually offered prophylactic total gastrectomy.
|
26363540 |
2015 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
CDH1a, a non-canonical transcript of the CDH1 gene, has been found to be expressed in some gastric cancer (GC) cell lines, whereas it is absent in normal gastric mucosa.
|
29443099 |
2018 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cell adhesion molecule abnormalities such as those involving CDH1 may play an important role in diffuse-type gastric cancer development.
|
11979414 |
2002 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Characterization of a mutant E-cadherin protein encoded by a mutant gene frequently seen in diffuse-type human gastric carcinoma.
|
11058874 |
2000 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CIHM of CDH1 and DAP-kinase in non-neoplastic gastric mucosa corresponded to a risk of GC regardless of histological subtype, H. pylori infection status, gender and generation.
|
20150736 |
2010 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Combined analysis of E-cadherin gene (CDH1) promoter hypermethylation and E-cadherin protein expression in patients with gastric cancer: implications for treatment with demethylating drugs.
|
14998854 |
2004 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Correlation of a single nucleotide polymorphism in the E-cadherin gene promoter with tumorigenesis and progression of gastric carcinoma in Japan.
|
12851691 |
2003 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer.
|
26334097 |
2015 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Downregulation of E-cadherin (CDH1) plays a key role in the development of diffuse-type gastric cancer, and DNA methylation is a major cause of the gene's silencing.
|
21273772 |
2011 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
E-cadherin/CDH1 gene methylation is an important cause for its gene silence in diffuse variant gastric carcinoma.
|
16830381 |
2006 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene.
|
23812922 |
2014 |