TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs4570625
rs4570625 		0.724 0.200 12 71938143 upstream gene variant G/T snv 0.27
CUI: C0860603
Disease: Anxiety symptoms
Anxiety symptoms 		0.020 1.000 2 2009 2016
dbSNP: rs120074176
rs120074176 		1.000 12 71979053 missense variant C/T snv 2.4E-05
CUI: C2751802
Disease: ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7
ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7 		0.800 1.000 1 2008 2008
dbSNP: rs1386483
rs1386483 		0.790 0.080 12 72018714 intron variant T/C snv 0.53
CUI: C0564567
Disease: Impulsive character (finding)
Impulsive character (finding) 		0.010 1.000 1 2012 2012
dbSNP: rs1386483
rs1386483 		0.790 0.080 12 72018714 intron variant T/C snv 0.53
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.010 1.000 1 2007 2007
dbSNP: rs1386494
rs1386494 		0.790 0.120 12 71958763 intron variant T/C;G snv 0.82
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
PARKINSON DISEASE, LATE-ONSET 		0.010 1.000 1 2007 2007
dbSNP: rs1386497
rs1386497 		1.000 12 71998510 intron variant C/A snv 0.83
CUI: C3496069
Disease: cocaine use
cocaine use 		0.010 1.000 1 2015 2015
dbSNP: rs17110563
rs17110563 		0.827 0.080 12 71972526 missense variant C/T snv 1.2E-03 1.1E-03
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		0.700 1.000 1 2012 2012
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C0008060
Disease: child abuse behavior
child abuse behavior 		0.010 1.000 1 2017 2017
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C4017088
Disease: UNIPOLAR DEPRESSION, SUSCEPTIBILITY TO
UNIPOLAR DEPRESSION, SUSCEPTIBILITY TO 		0.700 0
dbSNP: rs17110563
rs17110563 		0.827 0.080 12 71972526 missense variant C/T snv 1.2E-03 1.1E-03
CUI: C1862077
Disease: BIPOLAR AFFECTIVE DISORDER, SUSCEPTIBILITY TO
BIPOLAR AFFECTIVE DISORDER, SUSCEPTIBILITY TO 		0.700 0
dbSNP: rs4570625
rs4570625 		0.724 0.200 12 71938143 upstream gene variant G/T snv 0.27
CUI: C0003467
Disease: Anxiety
Anxiety 		Behavior and Behavior Mechanisms 0.020 1.000 2 2013 2015
dbSNP: rs11178999
rs11178999 		12 71939790 intron variant G/A snv 0.27
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2019 2019
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0344315
Disease: Depressed mood
Depressed mood 		Behavior and Behavior Mechanisms 0.010 1.000 1 2013 2013
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0011570
Disease: Mental Depression
Mental Depression 		Behavior and Behavior Mechanisms 0.010 1.000 1 2013 2013
dbSNP: rs12229394
rs12229394 		0.925 0.080 12 71999134 intron variant G/A snv 0.29
CUI: C0344315
Disease: Depressed mood
Depressed mood 		Behavior and Behavior Mechanisms 0.010 1.000 1 2010 2010
dbSNP: rs12229394
rs12229394 		0.925 0.080 12 71999134 intron variant G/A snv 0.29
CUI: C0011570
Disease: Mental Depression
Mental Depression 		Behavior and Behavior Mechanisms 0.010 1.000 1 2010 2010
dbSNP: rs1317926854
rs1317926854 		1.000 0.040 12 72031625 missense variant A/G snv
CUI: C1842981
Disease: NEUROTICISM
NEUROTICISM 		Behavior and Behavior Mechanisms 0.010 1.000 1 2011 2011
dbSNP: rs1386483
rs1386483 		0.790 0.080 12 72018714 intron variant T/C snv 0.53
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2009 2009
dbSNP: rs1473473
rs1473473 		0.925 0.080 12 72010598 intron variant C/A;T snv 0.81
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2013 2013
dbSNP: rs1843809
rs1843809 		0.851 0.080 12 71954918 intron variant G/T snv 0.77
CUI: C0424166
Disease: Social Anxiety
Social Anxiety 		Behavior and Behavior Mechanisms 0.010 1.000 1 2015 2015
dbSNP: rs1843809
rs1843809 		0.851 0.080 12 71954918 intron variant G/T snv 0.77
CUI: C0003467
Disease: Anxiety
Anxiety 		Behavior and Behavior Mechanisms 0.010 1.000 1 2015 2015
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2009 2009
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C0003467
Disease: Anxiety
Anxiety 		Behavior and Behavior Mechanisms 0.010 1.000 1 2015 2015
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		Behavior and Behavior Mechanisms 0.010 < 0.001 1 2018 2018
dbSNP: rs4570625
rs4570625 		0.724 0.200 12 71938143 upstream gene variant G/T snv 0.27
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2017 2017