TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		Mental Disorders 0.020 1.000 2 2014 2015
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		Mental Disorders 0.010 1.000 1 2010 2010
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0013146
Disease: Drug abuse
Drug abuse 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2014 2014
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0026691
Disease: Mucocutaneous Lymph Node Syndrome
Mucocutaneous Lymph Node Syndrome 		Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases 0.010 1.000 1 2010 2010
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0029121
Disease: Oppositional Defiant Disorder
Oppositional Defiant Disorder 		Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0011570
Disease: Mental Depression
Mental Depression 		Behavior and Behavior Mechanisms 0.010 1.000 1 2015 2015
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0344315
Disease: Depressed mood
Depressed mood 		Behavior and Behavior Mechanisms 0.010 1.000 1 2015 2015
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		Mental Disorders 0.010 1.000 1 2010 2010
dbSNP: rs10784941
rs10784941 		1.000 0.040 12 71942732 intron variant A/G snv 0.40
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		Mental Disorders 0.010 1.000 1 2012 2012
dbSNP: rs10879357
rs10879357 		1.000 0.040 12 72020783 intron variant A/G snv 0.59
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		Mental Disorders 0.010 1.000 1 2011 2011
dbSNP: rs11178998
rs11178998 		1.000 0.040 12 71938935 5 prime UTR variant A/G snv 5.7E-02
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs1317926854
rs1317926854 		1.000 0.040 12 72031625 missense variant A/G snv
CUI: C1842981
Disease: NEUROTICISM
NEUROTICISM 		Behavior and Behavior Mechanisms 0.010 1.000 1 2011 2011
dbSNP: rs1386486
rs1386486 		0.827 0.080 12 72018440 intron variant A/G snv 0.53
CUI: C1970945
Disease: MAJOR AFFECTIVE DISORDER 6
MAJOR AFFECTIVE DISORDER 6 		Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386486
rs1386486 		0.827 0.080 12 72018440 intron variant A/G snv 0.53
CUI: C1852197
Disease: MAJOR AFFECTIVE DISORDER 1
MAJOR AFFECTIVE DISORDER 1 		Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386486
rs1386486 		0.827 0.080 12 72018440 intron variant A/G snv 0.53
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386486
rs1386486 		0.827 0.080 12 72018440 intron variant A/G snv 0.53
CUI: C1970943
Disease: MAJOR AFFECTIVE DISORDER 4
MAJOR AFFECTIVE DISORDER 4 		Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386486
rs1386486 		0.827 0.080 12 72018440 intron variant A/G snv 0.53
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs7954758
rs7954758 		1.000 0.040 12 71942014 intron variant A/G snv 9.6E-02
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		Mental Disorders 0.020 1.000 2 2017 2018
dbSNP: rs11179000
rs11179000 		0.925 0.040 12 71944848 intron variant A/T snv 0.31
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		Mental Disorders 0.010 < 0.001 1 2006 2006
dbSNP: rs11179000
rs11179000 		0.925 0.040 12 71944848 intron variant A/T snv 0.31
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		Mental Disorders 0.010 1.000 1 2011 2011
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C0033139
Disease: Primary Insomnia
Primary Insomnia 		Nervous System Diseases; Mental Disorders 0.010 < 0.001 1 2018 2018
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2012 2012
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		Mental Disorders 0.010 1.000 1 2017 2017
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders 0.010 1.000 1 2009 2009