TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		Mental Disorders 0.020 1.000 2 2014 2015
dbSNP: rs120074176
rs120074176 		1.000 12 71979053 missense variant C/T snv 2.4E-05
CUI: C2751802
Disease: ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7
ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7 		0.800 1.000 1 2008 2008
dbSNP: rs1317926854
rs1317926854 		1.000 0.040 12 72031625 missense variant A/G snv
CUI: C1842981
Disease: NEUROTICISM
NEUROTICISM 		Behavior and Behavior Mechanisms 0.010 1.000 1 2011 2011
dbSNP: rs4565946
rs4565946 		0.827 0.080 12 71942989 intron variant C/A;G;T snv
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		Mental Disorders 0.010 1.000 1 2012 2012
dbSNP: rs4565946
rs4565946 		0.827 0.080 12 71942989 intron variant C/A;G;T snv
CUI: C0040188
Disease: Tic disorder
Tic disorder 		Nervous System Diseases; Mental Disorders 0.010 1.000 1 2013 2013
dbSNP: rs4565946
rs4565946 		0.827 0.080 12 71942989 intron variant C/A;G;T snv
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		Mental Disorders 0.010 1.000 1 2013 2013
dbSNP: rs4565946
rs4565946 		0.827 0.080 12 71942989 intron variant C/A;G;T snv
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		Mental Disorders 0.010 1.000 1 2011 2011
dbSNP: rs4565946
rs4565946 		0.827 0.080 12 71942989 intron variant C/A;G;T snv
CUI: C2169806
Disease: recurrent muscle twitches (symptom)
recurrent muscle twitches (symptom) 		Pathological Conditions, Signs and Symptoms; Nervous System Diseases 0.010 1.000 1 2013 2013
dbSNP: rs4565946
rs4565946 		0.827 0.080 12 71942989 intron variant C/A;G;T snv
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder 		Mental Disorders 0.010 1.000 1 2006 2006
dbSNP: rs4565946
rs4565946 		0.827 0.080 12 71942989 intron variant C/A;G;T snv
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		Mental Disorders 0.010 < 0.001 1 2007 2007
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		Mental Disorders 0.010 1.000 1 2010 2010
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0013146
Disease: Drug abuse
Drug abuse 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2014 2014
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0026691
Disease: Mucocutaneous Lymph Node Syndrome
Mucocutaneous Lymph Node Syndrome 		Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases 0.010 1.000 1 2010 2010
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0029121
Disease: Oppositional Defiant Disorder
Oppositional Defiant Disorder 		Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0011570
Disease: Mental Depression
Mental Depression 		Behavior and Behavior Mechanisms 0.010 1.000 1 2015 2015
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0344315
Disease: Depressed mood
Depressed mood 		Behavior and Behavior Mechanisms 0.010 1.000 1 2015 2015
dbSNP: rs7305115
rs7305115 		0.807 0.200 12 71979082 synonymous variant A/C;G;T snv 4.0E-06; 0.56
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		Mental Disorders 0.010 1.000 1 2010 2010
dbSNP: rs7963720
rs7963720 		1.000 0.080 12 71972406 intron variant C/G;T snv
CUI: C0019337
Disease: Heroin Dependence
Heroin Dependence 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2008 2008
dbSNP: rs7963803
rs7963803 		12 71937538 upstream gene variant C/A;G snv
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		Nervous System Diseases; Cardiovascular Diseases 0.010 1.000 1 2019 2019
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		Mental Disorders 0.030 1.000 3 2006 2015
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		Mental Disorders 0.030 1.000 3 2006 2015
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0344315
Disease: Depressed mood
Depressed mood 		Behavior and Behavior Mechanisms 0.010 1.000 1 2013 2013
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0588008
Disease: Severe depression
Severe depression 		Mental Disorders 0.010 1.000 1 2019 2019
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0011570
Disease: Mental Depression
Mental Depression 		Behavior and Behavior Mechanisms 0.010 1.000 1 2013 2013
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		Mental Disorders 0.010 1.000 1 2013 2013