TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs4570625
rs4570625 		0.724 0.200 12 71938143 upstream gene variant G/T snv 0.27
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2017 2017
dbSNP: rs17110747
rs17110747 		0.882 0.120 12 72032174 3 prime UTR variant G/A snv 0.12
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2014 2014
dbSNP: rs4570625
rs4570625 		0.724 0.200 12 71938143 upstream gene variant G/T snv 0.27
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		Chemically-Induced Disorders; Mental Disorders 0.010 1.000 1 2014 2014
dbSNP: rs1473473
rs1473473 		0.925 0.080 12 72010598 intron variant C/A;T snv 0.81
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		Mental Disorders 0.020 1.000 2 2011 2013
dbSNP: rs11179027
rs11179027 		1.000 0.040 12 71983532 intron variant G/C snv 0.26
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		Mental Disorders 0.010 1.000 1 2013 2013
dbSNP: rs4570625
rs4570625 		0.724 0.200 12 71938143 upstream gene variant G/T snv 0.27
CUI: C0003467
Disease: Anxiety
Anxiety 		Behavior and Behavior Mechanisms 0.020 1.000 2 2013 2015
dbSNP: rs1843809
rs1843809 		0.851 0.080 12 71954918 intron variant G/T snv 0.77
CUI: C0003467
Disease: Anxiety
Anxiety 		Behavior and Behavior Mechanisms 0.010 1.000 1 2015 2015
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C0003467
Disease: Anxiety
Anxiety 		Behavior and Behavior Mechanisms 0.010 1.000 1 2015 2015
dbSNP: rs4570625
rs4570625 		0.724 0.200 12 71938143 upstream gene variant G/T snv 0.27
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		Mental Disorders 0.020 1.000 2 2013 2015
dbSNP: rs1843809
rs1843809 		0.851 0.080 12 71954918 intron variant G/T snv 0.77
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		Mental Disorders 0.010 1.000 1 2015 2015
dbSNP: rs4290270
rs4290270 		0.724 0.320 12 72022455 synonymous variant A/T snv 0.57 0.55
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		Mental Disorders 0.010 1.000 1 2015 2015
dbSNP: rs4565946
rs4565946 		0.827 0.080 12 71942989 intron variant C/A;G;T snv
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		Mental Disorders 0.010 1.000 1 2013 2013
dbSNP: rs4570625
rs4570625 		0.724 0.200 12 71938143 upstream gene variant G/T snv 0.27
CUI: C0860603
Disease: Anxiety symptoms
Anxiety symptoms 		0.020 1.000 2 2009 2016
dbSNP: rs11178997
rs11178997 		0.827 0.040 12 71938373 upstream gene variant T/A snv 0.12
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		Mental Disorders 0.020 1.000 2 2005 2009
dbSNP: rs4570625
rs4570625 		0.724 0.200 12 71938143 upstream gene variant G/T snv 0.27
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		Mental Disorders 0.020 1.000 2 2005 2009
dbSNP: rs17110690
rs17110690 		0.925 0.080 12 72014217 intron variant G/A snv 0.19
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		Mental Disorders 0.010 1.000 1 2015 2015
dbSNP: rs1843809
rs1843809 		0.851 0.080 12 71954918 intron variant G/T snv 0.77
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		Mental Disorders 0.010 1.000 1 2010 2010
dbSNP: rs120074176
rs120074176 		1.000 12 71979053 missense variant C/T snv 2.4E-05
CUI: C2751802
Disease: ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7
ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7 		0.800 1.000 1 2008 2008
dbSNP: rs139896303
rs139896303 		1.000 0.040 12 71972584 missense variant G/A snv 1.2E-04 5.6E-05
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		Mental Disorders 0.010 1.000 1 2012 2012
dbSNP: rs1843809
rs1843809 		0.851 0.080 12 71954918 intron variant G/T snv 0.77
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		Mental Disorders 0.010 1.000 1 2010 2010
dbSNP: rs2129575
rs2129575 		1.000 0.040 12 71946293 intron variant G/T snv 0.25
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		Mental Disorders 0.010 1.000 1 2012 2012
dbSNP: rs11179000
rs11179000 		0.925 0.040 12 71944848 intron variant A/T snv 0.31
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		Mental Disorders 0.010 < 0.001 1 2006 2006
dbSNP: rs4341581
rs4341581 		1.000 0.040 12 71941293 intron variant G/T snv 0.97
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		Mental Disorders 0.010 < 0.001 1 2006 2006
dbSNP: rs4565946
rs4565946 		0.827 0.080 12 71942989 intron variant C/A;G;T snv
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		Mental Disorders 0.010 < 0.001 1 2007 2007
dbSNP: rs4570625
rs4570625 		0.724 0.200 12 71938143 upstream gene variant G/T snv 0.27
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		Mental Disorders 0.010 < 0.001 1 2007 2007