|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The results indicated that lung cancer risk was significantly associated with miRNA-196a2 rs11614913 and miRNA-146a rs2910164.
|
29750042 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Liver carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed that miR-196a2 rs11614913 polymorphism is associated with cancer susceptibility, especially in lung cancer (homozygote comparison, OR =0.840, 95% CI =0.734-0.961; recessive model, OR =0.858, 95% CI =0.771-0.955), hepatocellular carcinoma (allelic contrast, OR =0.894, 95% CI =0.800-0.998; homozygote comparison, OR =0.900, 95% CI =0.813-0.997; recessive model, OR =0.800, 95% CI =0.678-0.944), and head and neck cancer (allelic contrast, OR =1.076, 95% CI =1.006-1.152; homozygote comparison, OR =1.214, 95% CI =1.043-1.413).
|
29535537 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, the present study explored the association between five common functional polymorphisms in miRNAs (i.e., miRNA-196a2C>T, rs11614913; miRNA-146aG>C, rs2910164; miRNA-423C>A, rs6505162; miRNA-608G>C, rs4919510; miRNA-27aC>T, rs895819) and the risk of BC.
|
29782194 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
The statistical analysis showed a significant relation between CC genotype of rs11614913(196a2) (codominant, odds ratio (OR) = 0.58, p = 0.02236; recessive, OR = 2.92, p = 0.01695; overdominant, OR = 0.44, p = 0.0113) and BC susceptibility.
|
29965793 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed that miR-196a2 rs11614913 polymorphism is associated with cance</span>r susceptibility, especially in lung cancer (homozygote comparison, OR =0.840, 95% CI =0.734-0.961; recessive model, OR =0.858, 95% CI =0.771-0.955), hepatocellular carcinoma (allelic contrast, OR =0.894, 95% CI =0.800-0.998; homozygote comparison, OR =0.900, 95% CI =0.813-0.997; recessive model, OR =0.800, 95% CI =0.678-0.944), and head and neck cancer (allelic contrast, OR =1.076, 95% CI =1.006-1.152; homozygote comparison, OR =1.214, 95% CI =1.043-1.413).
|
29535537 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed that miR-196a2 rs11614913 polymorphism is associated with cancer susceptibility, especially in lung cancer (homozygote comparison, OR =0.840, 95% CI =0.734-0.961; recessive model, OR =0.858, 95% CI =0.771-0.955), hepatocellular carcinoma (allelic contrast, OR =0.894, 95% CI =0.800-0.998; homozygote comparison, OR =0.900, 95% CI =0.813-0.997; recessive model, OR =0.800, 95% CI =0.678-0.944), and head and neck cancer (allelic contrast, OR =1.076, 95% CI =1.006-1.152; homozygote comparison, OR =1.214, 95% CI =1.043-1.413).
|
29535537 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed that miR-196a2 rs11614913 polymorphism is associated with cancer susceptibility, especially in lung cancer (homozygote comparison, OR =0.840, 95% CI =0.734-0.961; recessive model, OR =0.858, 95% CI =0.771-0.955), hepatocellular carcinoma (allelic contrast, OR =0.894, 95% CI =0.800-0.998; homozygote comparison, OR =0.900, 95% CI =0.813-0.997; recessive model, OR =0.800, 95% CI =0.678-0.944), and head and neck cancer (allelic contrast, OR =1.076, 95% CI =1.006-1.152; homozygote comparison, OR =1.214, 95% CI =1.043-1.413).
|
29535537 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
The miR-196a2 (rs11614913) was not related to breast cancer (p > 0.05).
|
29521182 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The results indicated that lung cancer risk was significantly associated with miRNA-196a2 rs11614913 and miRNA-146a rs2910164.
|
29750042 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
The statistical analysis showed a significant relation between CC genotype of rs11614913(196a2) (codominant, odds ratio (OR) = 0.58, p = 0.02236; recessive, OR = 2.92, p = 0.01695; overdominant, OR = 0.44, p = 0.0113) and BC susceptibility.
|
29965793 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
The miR-196a2 (rs11614913) was not related to breast cancer (p > 0.05).
|
29521182 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggested that SNPs rs71428439 (miR-149), rs2910164 (miR-146a), rs928508 (mir-30c-1) and rs629367 (let-7a-2) were associated with the lung cancer prevalence, polymorphisms of rs11614913 (miR-196a-2) and rs9280508 (miR-30c-1) significantly influenced the patients' response to platinum-based chemotherapy, which may serve as potential clinical biomarkers to predict lung cancer risk and platinum-based chemotherapy response.
|
30069329 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
It was shown that 6 miRNAs SNPs (miR-608 rs4919510, miR-492 rs2289030, miR-378 rs1076064, miR-499 rs4919510, miR-149 rs2292832, miR-196a2 rs11614913) were associated with better cancer overall survival (OS) while let-7i rs10877887 was associated with poor OS; the homozygous and heterozygote genotype of miR-423 were related to poor cancer relapse-free survival (RFS) when compared with the wild genotype; miR-146 rs2910164 was linked to favorable cancer DFS while miR-196a2 rs11614913 was associated with poor DFS.
|
30619739 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings suggested that SNPs rs71428439 (miR-149), rs2910164 (miR-146a), rs928508 (mir-30c-1) and rs629367 (let-7a-2) were associated with the lung cancer prevalence, polymorphisms of rs11614913 (miR-196a-2) and rs9280508 (miR-30c-1) significantly influenced the patients' response to platinum-based chemotherapy, which may serve as potential clinical biomarkers to predict lung cancer risk and platinum-based chemotherapy response.
|
30069329 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, the present study explored the association between five common functional polymorphisms in miRNAs (i.e., miRNA-196a2C>T, rs11614913; miRNA-146aG>C, rs2910164; miRNA-423C>A, rs6505162; miRNA-608G>C, rs4919510; miRNA-27aC>T, rs895819) and the risk of BC.
|
29782194 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
<b>Results:</b> Three SNPs were significantly associated with survival of patients with colorectal cancer after correction for multiple testing, and two of the SNPs (<i>hsa-mir-196a-2</i> rs11614913 and <i>U85</i> rs714775) remained significant in multivariate analyses.
|
29483812 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed that miR-196a2 rs11614913 polymorphism is associated with cancer susceptibility, especially in lung cancer (homozygote comparison, OR =0.840, 95% CI =0.734-0.961; recessive model, OR =0.858, 95% CI =0.771-0.955), hepatocellular carcinoma (allelic contrast, OR =0.894, 95% CI =0.800-0.998; homozygote comparison, OR =0.900, 95% CI =0.813-0.997; recessive model, OR =0.800, 95% CI =0.678-0.944), and head and neck cancer (allelic contrast, OR =1.076, 95% CI =1.006-1.152; homozygote comparison, OR =1.214, 95% CI =1.043-1.413).
|
29535537 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, MIR196A2 rs11614913 might play a potential role in the pathogenesis of CRC i</span>n Iranian population.
|
29802998 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we investigated the association of hsa-mir-149 rs2292832 C/T, hsa-mir-146a rs2910164 G/C and hsa-mir-196a2 rs11614913 C/T and explored their roles in clinicopathological features of CRC progression in an Eastern Tunisian cohort.
|
29715515 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Liver carcinoma
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, hsa-<i>mir-146a</i> rs2910164 and hsa-<i>mir-34b/c</i> rs4938723 could be biomarkers for the HCC risk while hsa-<i>mir-196a-2</i> rs11614913 and hsa-<i>mir-149</i> rs2292832 had potential to be biomarkers for HBV-related HCC risk.
|
29976775 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
It was shown that 6 miRNAs SNPs (miR-608 rs4919510, miR-492 rs2289030, miR-378 rs1076064, miR-499 rs4919510, miR-149 rs2292832, miR-196a2 rs11614913) were associated with better cancer overall survival (OS) while let-7i rs10877887 was associated with poor OS; the homozygous and heterozygote genotype of miR-423 were related to poor cancer relapse-free survival (RFS) when compared with the wild genotype; miR-146 rs2910164 was linked to favorable cancer DFS while miR-196a2 rs11614913 was associated with poor DFS.
|
30619739 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, the pooled analysis showed that miRNA-196a2 rs11614913 was associated with a decreased cancer risk (CC vs TT: OR = 1.25, 95% CI: 1.09-1.44; CT vs TT: OR = 1.26, 95% CI: 1.03-1.53).
|
29750042 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
Maturation of MIR196A2 as a gene regulator with a high potential for targeted cancer therapy can be modulated by the rs11614913 polymorphism.
|
29802998 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
Although for rs11614913 and rs3746444 polymorphisms, overall analyses suggested negative results, for rs11614913 polymorphism, when subgroup analysis was conducted by cancer type, a significantly decreased risk of renal cell cancer was identified in recessive model.
|
29491365 |
2018 |
|
rs11614913
|
HOXC6;MIR196A2
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation |
BEFREE |
The results indicated that lung cancer risk was significantly associated with miRNA-196a2 rs11614913 and miRNA-146a rs2910164.
|
29750042 |
2018 |