|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our work is to study the possible role of clinical variables, neuropsychological performance, and the 5HTTLPR, rs25531, and val108/58Met COMT polymorphisms on the prediction of depression remission after 12 weeks' treatment with fluoxetine.
|
24446536 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Although preliminary, these findings identify anhedonia as a promising mechanism linking 5-HTTLPR/rs25531 genotype and stress to depression.
|
22094432 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our work is to study the possible role of clinical variables, neuropsychological performance, and the 5HTTLPR, rs25531, and val108/58Met COMT polymorphisms on the prediction of depression remission after 12 weeks' treatment with fluoxetine.
|
24446536 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
Although preliminary, these findings identify anhedonia as a promising mechanism linking 5-HTTLPR/rs25531 genotype and stress to depression.
|
22094432 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution.
|
22520017 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution.
|
22520017 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our work is to study the possible role of clinical variables, neuropsychological performance, and the 5HTTLPR, rs25531, and val108/58Met COMT polymorphisms on the prediction of depression remission after 12 weeks' treatment with fluoxetine.
|
24446536 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Although preliminary, these findings identify anhedonia as a promising mechanism linking 5-HTTLPR/rs25531 genotype and stress to depression.
|
22094432 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
Unmedicated, young adults with low current depression and anxiety symptoms (N=106) were genotyped for the 5-HTTLPR, including the single nucleotide polymorphism (SNP) rs25531 in the long allele of the 5-HTTLPR.
|
20694965 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Stratification for anxious versus nonanxious depression revealed a significantly detrimental effect of the less active 5-HTTLPR S allele (p = 0.007) and 5-HTTLPR/5-HTT rs25531 haplotypes on treatment response in patients with anxious depression.
|
20588071 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Stratification for anxious versus nonanxious depression revealed a significantly detrimental effect of the less active 5-HTTLPR S allele (p = 0.007) and 5-HTTLPR/5-HTT rs25531 haplotypes on treatment response in patients with anxious depression.
|
20588071 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
Stratification for anxious versus nonanxious depression revealed a significantly detrimental effect of the less active 5-HTTLPR S allele (p = 0.007) and 5-HTTLPR/5-HTT rs25531 haplotypes on treatment response in patients with anxious depression.
|
20588071 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Unmedicated, young adults with low current depression and anxiety symptoms (N=106) were genotyped for the 5-HTTLPR, including the single nucleotide polymorphism (SNP) rs25531 in the long allele of the 5-HTTLPR.
|
20694965 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Using a large twin sample of 3,243 individuals from 2,230 families aged 18-95 years (mean = 32.3, SD = 13.6) we investigate the interaction between 5HTTLPR (subtyped with SNP rs25531) and stressful events on risk of depression and suicidality using both ordinal regressions and item response theory analyses.
|
19911410 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
|
20515362 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Unmedicated, young adults with low current depression and anxiety symptoms (N=106) were genotyped for the 5-HTTLPR, including the single nucleotide polymorphism (SNP) rs25531 in the long allele of the 5-HTTLPR.
|
20694965 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Using a large twin sample of 3,243 individuals from 2,230 families aged 18-95 years (mean = 32.3, SD = 13.6) we investigate the interaction between 5HTTLPR (subtyped with SNP rs25531) and stressful events on risk of depression and suicidality using both ordinal regressions and item response theory analyses.
|
19911410 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
Using a large twin sample of 3,243 individuals from 2,230 families aged 18-95 years (mean = 32.3, SD = 13.6) we investigate the interaction between 5HTTLPR (subtyped with SNP rs25531) and stressful events on risk of depression and suicidality using both ordinal regressions and item response theory analyses.
|
19911410 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
To further delineate the impact of 5-HTT gene variation on psychopathology in depression, in this analysis the influence of the 5-HTTLPR and the functionally closely related 5-HTT rs25531 was investigated in 340 Caucasian patients with a major depressive episode (DSM-IV) with particular attention to the subtype of depression (melancholic depression versus atypical depression) applying logistic regression models adjusted for age and gender.
|
18050262 |
2008 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
To further delineate the impact of 5-HTT gene variation on psychopathology in depression, in this analysis the influence of the 5-HTTLPR and the functionally closely related 5-HTT rs25531 was investigated in 340 Caucasian patients with a major depressive episode (DSM-IV) with particular attention to the subtype of depression (melancholic depression versus atypical depression) applying logistic regression models adjusted for age and gender.
|
18050262 |
2008 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
To further delineate the impact of 5-HTT gene variation on psychopathology in depression, in this analysis the influence of the 5-HTTLPR and the functionally closely related 5-HTT rs25531 was investigated in 340 Caucasian patients with a major depressive episode (DSM-IV) with particular attention to the subtype of depression (melancholic depression versus atypical depression) applying logistic regression models adjusted for age and gender.
|
18050262 |
2008 |
|
rs25531
|
SLC6A4;LOC105371720
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
rs25531
|
SLC6A4;LOC105371720
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation |
BEFREE |
Lower AluJb methylation was particularly found in 5-HTTLPR/rs25531 risk allele carriers under stress and correlated with less depressive episodes. fMRI analysis revealed a significant interaction of AluJb methylation and diagnosis in the amygdala, with MDD patients showing lower AluJb methylation associated with decreased amygdala reactivity.
|
29114103 |
2018 |