|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution.
|
22520017 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Using a large twin sample of 3,243 individuals from 2,230 families aged 18-95 years (mean = 32.3, SD = 13.6) we investigate the interaction between 5HTTLPR (subtyped with SNP rs25531) and stressful events on risk of depression and suicidality using both ordinal regressions and item response theory analyses.
|
19911410 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes.
|
24862560 |
2014 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Depression was measured at both diagnostic (major depression according to DSM-IV) and symptomatic (subthreshold depression) levels of caseness, in addition to 5-HTTLPR and rs25531 genotyping and diurnal cortisol measures.
|
28024274 |
2017 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
Depression was measured at both diagnostic (major depression according to DSM-IV) and symptomatic (subthreshold depression) levels of caseness, in addition to 5-HTTLPR and rs25531 genotyping and diurnal cortisol measures.
|
28024274 |
2017 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our work is to study the possible role of clinical variables, neuropsychological performance, and the 5HTTLPR, rs25531, and val108/58Met COMT polymorphisms on the prediction of depression remission after 12 weeks' treatment with fluoxetine.
|
24446536 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
Using a large twin sample of 3,243 individuals from 2,230 families aged 18-95 years (mean = 32.3, SD = 13.6) we investigate the interaction between 5HTTLPR (subtyped with SNP rs25531) and stressful events on risk of depression and suicidality using both ordinal regressions and item response theory analyses.
|
19911410 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
The 5-HTTLPR polymorphism in the gene's promoter region has a short (S) and a long (L) allele, of which L contains a further SNP (rs25531), resulting in a triallelic polymorphism: La, Lg, and S. Both S and Lg result in increased serotonin signaling (to simplify, we refer to both alleles as 'S'), which in turn appears associated with depression vulnerability, specifically in individuals with stressful events.
|
26232751 |
2015 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese.
|
27788383 |
2017 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
Seeking to explain the adolescent gender difference in depression, this study examined the effects of 5-HTTLPR (rs25531), the monoamine oxidase A-upstream variable number tandem repeat (MAOA-uVNTR), and negative life events (NLE).
|
22836288 |
2013 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressive disorder
|
|
0.100 |
GeneticVariation |
BEFREE |
To further delineate the impact of 5-HTT gene variation on psychopathology in depression, in this analysis the influence of the 5-HTTLPR and the functionally closely related 5-HTT rs25531 was investigated in 340 Caucasian patients with a major depressive episode (DSM-IV) with particular attention to the subtype of depression (melancholic depression versus atypical depression) applying logistic regression models adjusted for age and gender.
|
18050262 |
2008 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Although preliminary, these findings identify anhedonia as a promising mechanism linking 5-HTTLPR/rs25531 genotype and stress to depression.
|
22094432 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Depressed mood
|
|
0.100 |
GeneticVariation |
BEFREE |
Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese.
|
27788383 |
2017 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Depression was measured at both diagnostic (major depression according to DSM-IV) and symptomatic (subthreshold depression) levels of caseness, in addition to 5-HTTLPR and rs25531 genotyping and diurnal cortisol measures.
|
28024274 |
2017 |
|
rs25531
|
SLC6A4;LOC105371720
|
Mental Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
The serotonin transporter (5-HTT) and the 5-HTTLPR/rs25531 polymorphisms in its gene (SLC6A4) have been associated with depression, increased stress-response, and brain structural alterations such as reduced hippocampal volumes.
|
24862560 |
2014 |
|
rs25531
|
SLC6A4;LOC105371720
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation |
BEFREE |
The 5-HTTLPR/rs25531-haplotype had a suggestive effect on course of MDD, but not on presence of MDD.
|
23021380 |
2013 |
|
rs25531
|
SLC6A4;LOC105371720
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation |
BEFREE |
A variable number of tandem repeats (short (S) vs long (L)) in the promoter region of the serotonin transporter gene (5-HTTLPR) and a functional variant of a single-nucleotide polymorphism (rs25531) in 5-HTTLPR have been recently associated with increased risk for major depressive disorder (MDD).
|
20090673 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation |
BEFREE |
Lower AluJb methylation was particularly found in 5-HTTLPR/rs25531 risk allele carriers under stress and correlated with less depressive episodes. fMRI analysis revealed a significant interaction of AluJb methylation and diagnosis in the amygdala, with MDD patients showing lower AluJb methylation associated with decreased amygdala reactivity.
|
29114103 |
2018 |
|
rs25531
|
SLC6A4;LOC105371720
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
rs25531
|
SLC6A4;LOC105371720
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation |
BEFREE |
The aim of our work is to study the possible role of clinical variables, neuropsychological performance, and the 5HTTLPR, rs25531, and val108/58Met COMT polymorphisms in the prediction of the response to fluoxetine after 4weeks of treatment in a sample of patient with MDD.
|
20584552 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Major Depressive Disorder
|
|
0.060 |
GeneticVariation |
BEFREE |
49 patients with major depression and SSRI treatment were genotyped for the 5-HTTLPR locus including the rs25531.
|
22086748 |
2012 |
|
rs25531
|
SLC6A4;LOC105371720
|
Obsessive-Compulsive Disorder
|
|
0.050 |
GeneticVariation |
BEFREE |
The present study investigated the possible correlation of SLC6A4 polymorphisms (5-HTTLPR, rs25532, rs25531) in Iranian OCD patients considering gender, age of onset, family history of psychiatric disorders, obsessive and compulsive subtypes and severities.
|
28691545 |
2018 |
|
rs25531
|
SLC6A4;LOC105371720
|
Obsessive-Compulsive Disorder
|
|
0.050 |
GeneticVariation |
BEFREE |
The higher expressing 5-HTTLPR/rs25531 LA allele was more prevalent in TD probands than in controls (χ(2) = 5.75; P = 0.017; odds ratio [OR], 1.35); and, in a secondary analysis, surprisingly, it was significantly more frequent in probands who had TD alone than in those who had TD plus OCD (Fisher's exact test; P = 0.0006; OR, 2.29).
|
23630162 |
2013 |
|
rs25531
|
SLC6A4;LOC105371720
|
Abnormal behavior
|
|
0.050 |
GeneticVariation |
BEFREE |
We investigated, in a large cohort of 5,608 controls and subjects suffering from various psychiatric disorders, the frequency of haplotypes and corresponding genotypes combining the 5-HTTLPR and the other serotonin transporter promoter functional variant (rs25531).
|
20862697 |
2010 |
|
rs25531
|
SLC6A4;LOC105371720
|
Abnormal behavior
|
|
0.050 |
GeneticVariation |
BEFREE |
Comparing the genotypic and allelic frequencies of AD without and with BPSD, we did not find a difference for the 5-HTTLPR or the rs25531, even after stratification according to single SBI-BP item.
|
19625753 |
2009 |