|
rs2569190
|
CD14;TMCO6
|
Coronary heart disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of COL4A1 (rs605143, rs565470) and CD14 (rs2569190) genes polymorphism with coronary artery disease.
|
29299748 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the accumulating evidence does not support an association of IL-13 SNP rs1800925 and CD14 SNP rs2569190 with AR risk.
|
29687183 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, CD14 (rs2569190), CC (P = 0.008) genotypes, and C allele (P = 0.007) were found to be a positive risk factor, while TT genotype (P = 0.045) and T allele (P = 0.007) as negative risk factor for CAD.
|
29299748 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Graves Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In genetic model analysis, the allele model, recessive model, and homozygous model of rs2569190 and rs2915863 embodied strong correlations with GD after the adjusting of age and gender (<i>P</i> = 0.014, <i>P</i> = 0.015, <i>P</i> = 0.009, and <i>P</i> = 0.014, <i>P</i> = 0.001, <i>P</i> = 0.006, respectively).
|
30700980 |
2018 |
|
rs2569192
|
CD14;TMCO6
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The study was aimed to determine whether four single nucleotide polymorphisms (rs2915863, rs2569190, rs2569192, and rs2563298) of CD14 are associated with AITDs and its subgroups of GD and HT.
|
30700980 |
2018 |
|
rs2569192
|
CD14;TMCO6
|
Graves Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
The study was aimed to determine whether four single nucleotide polymorphisms (rs2915863, rs2569190, rs2569192, and rs2563298) of CD14 are associated with AITDs and its subgroups of GD and HT.
|
30700980 |
2018 |
|
rs2915863
|
CD14;TMCO6
|
Graves Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In genetic model analysis, the allele model, recessive model, and homozygous model of rs2569190 and rs2915863 embodied strong correlations with GD after the adjusting of age and gender (<i>P</i> = 0.014, <i>P</i> = 0.015, <i>P</i> = 0.009, and <i>P</i> = 0.014, <i>P</i> = 0.001, <i>P</i> = 0.006, respectively).
|
30700980 |
2018 |
|
rs5744454
|
CD14;TMCO6
|
Complicated malaria
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data not only reinstates that CD14 of TLR pathway plays a predominant role in P. falciparum malaria, it establishes a functional basis for genetic association of rs5744454 with P. falciparum severe malaria by demonstrating a cis-regulatory role of this promoter polymorphism.
|
30337251 |
2018 |
|
rs2569190
|
CD14;TMCO6
|
Respiratory Tract Infections
|
|
0.010 |
GeneticVariation |
BEFREE |
In children with TT genotype at rs2569190, a higher prenatal intake of vitamins A and C, fruits, and total FV decreased RTI risk (P-trend <0.05), while in infants with TC+CC genotype, a higher prenatal intake of fruit increased RTI risk (P-trend <0.05).
|
27830580 |
2017 |
|
rs2569190
|
CD14;TMCO6
|
Generalized chronic periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of the present study suggest that the T allele and the TT genotype of the rs2569190 SNP in the promoter region of the CD14 gene are associated with GCP in a South Indian population of Tamil ethnicity.
|
28829191 |
2017 |
|
rs2569190
|
CD14;TMCO6
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The CD14 rs2569190 TT Genotype is Associated with Chronic Periodontitis.
|
28829191 |
2017 |
|
rs5744455
|
CD14;TMCO6
|
Carcinoma of larynx
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggested that the genetic variation of CD14, rs5744455, is related to the susceptibility to laryngeal cancer, providing a theoretical basis for the study of the pathogenesis of laryngeal cancer.
|
29077168 |
2017 |
|
rs5744455
|
CD14;TMCO6
|
Malignant neoplasm of larynx
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggested that the genetic variation of CD14, rs5744455, is related to the susceptibility to laryngeal cancer, providing a theoretical basis for the study of the pathogenesis of laryngeal cancer.
|
29077168 |
2017 |
|
rs2569190
|
CD14;TMCO6
|
Primary biliary cirrhosis
|
|
0.010 |
GeneticVariation |
BEFREE |
PSC and LTx cohort patients and primary biliary cirrhosis (PBC) control patients were genotyped for the CD14 -260C>T (rs2569190) polymorphism, and genotypes were correlated with long-term clinical outcome.
|
26970220 |
2016 |
|
rs2569190
|
CD14;TMCO6
|
Primary sclerosing cholangitis
|
|
0.010 |
GeneticVariation |
BEFREE |
PSC and LTx cohort patients and primary biliary cirrhosis (PBC) control patients were genotyped for the CD14 -260C>T (rs2569190) polymorphism, and genotypes were correlated with long-term clinical outcome.
|
26970220 |
2016 |
|
rs2569190
|
CD14;TMCO6
|
Posterior subcapsular cataract
|
|
0.010 |
GeneticVariation |
BEFREE |
PSC and LTx cohort patients and primary biliary cirrhosis (PBC) control patients were genotyped for the CD14 -260C>T (rs2569190) polymorphism, and genotypes were correlated with long-term clinical outcome.
|
26970220 |
2016 |
|
rs2569190
|
CD14;TMCO6
|
Acute periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the meta-analysis was to evaluate the precise association between five widely-evaluated polymorphisms (CD14 -260C/T (rs2569190), Toll-like receptor (TLR) 2 2408G/A (rs5743708), TLR4 896A/G (rs4986790), TLR4 1196C/T (rs4986791), mannose-binding lectin (MBL) codon 54 (rs1800450)) within the PRRs and susceptibility to either chronic (CP) or aggressive periodontitis (AgP).
|
26079505 |
2015 |
|
rs2569190
|
CD14;TMCO6
|
Aggressive Periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the meta-analysis was to evaluate the precise association between five widely-evaluated polymorphisms (CD14 -260C/T (rs2569190), Toll-like receptor (TLR) 2 2408G/A (rs5743708), TLR4 896A/G (rs4986790), TLR4 1196C/T (rs4986791), mannose-binding lectin (MBL) codon 54 (rs1800450)) within the PRRs and susceptibility to either chronic (CP) or aggressive periodontitis (AgP).
|
26079505 |
2015 |
|
rs2569190
|
CD14;TMCO6
|
IgE-mediated allergic asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the TT genotypes for rs2569190 were significantly associated with an increased risk of atopic asthma compared with those carrying the wild-type homozygous CC genotypes [adjusted odds ratio (OR) by gender and age, from 1.075-2.398, P = 0.025].
|
25966203 |
2015 |
|
rs2569190
|
CD14;TMCO6
|
Allergic asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the TT genotypes for rs2569190 were significantly associated with an increased risk of atopic asthma compared with those carrying the wild-type homozygous CC genotypes [adjusted odds ratio (OR) by gender and age, from 1.075-2.398, P = 0.025].
|
25966203 |
2015 |
|
rs2563298
|
CD14;TMCO6
|
Septicemia
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11536889 polymorphism in TLR4 and rs2563298 polymorphism in CD14, and two haplotypes were associated with increased susceptibility to sepsis.
|
25394369 |
2014 |
|
rs2563298
|
CD14;TMCO6
|
Sepsis
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11536889 polymorphism in TLR4 and rs2563298 polymorphism in CD14, and two haplotypes were associated with increased susceptibility to sepsis.
|
25394369 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Severe Sepsis
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes GG of rs2569190 (the CD14 gene) and AT of rs4073 (the IL8 gene) were associated with a significantly increased risk of developing severe sepsis (p = 0.05 and p = 0.01).
|
25000179 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Crohn Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
rs2569190
|
CD14;TMCO6
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |