|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that in the group of mestizo schoolchildren studied, the Arg16Gly and Gln27Glu polymorphisms are not markers of susceptibility or severity of asthma and do not affect ADRB2 gene expression during the rescue therapy.
|
22328447 |
2012 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, Gly16Arg (rs1042713) and Gln27Glu (rs1042714) in the ADRB2 gene were not associated with blood pressure, hypertension or CVD either in the population overall or in women and men separately.
|
21883537 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
CART analysis showed that smoking parents who overate and carried the Arg allele, ADRB2 R16G, had an odds ratio (OR) of 11.7 (95% confidence interval (CI), 2.13-64.04) for obesity compared to non-smoking parents who had none of these factors.
|
22094842 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Stratification analyses by obesity showed that A46G polymorphism was related to the prevalence of hypertension in the obese population (GG vs. AG vs. AA, P<0.001, OR = 1.645, 95%CI [1.258-2.151]).
|
21483652 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although each polymorphism of β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G is known to be associated with obesity, the interaction among these polymorphisms is not fully understood.
|
21959333 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We analyzed β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G polymorphisms by the Smart Amplification Process 2 in 222 Japanese subjects without the medication of hypertension, dyslipidemia or diabetes, and investigated the association between the physical and metabolic characteristics and the combination of these polymorphisms.
|
21959333 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Stratification analyses by obesity showed that A46G polymorphism was related to the prevalence of hypertension in the obese population (GG vs. AG vs. AA, P<0.001, OR = 1.645, 95%CI [1.258-2.151]).
|
21483652 |
2011 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We selected 604 subjects with current asthma from the European Community Respiratory Health Study to evaluate whether asthma control and lung function decline were associated with Gly16Arg polymorphism, and to test whether LABA or inhaled corticosteroid (ICS) use modified these effects.
|
21436355 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Together, our findings suggest evidence for a two-locus interaction between the LEPR Gln223Arg and ADRB2 Arg16Gly variants in the risk of overweight/obesity, and highlight further the importance of multilocus effects in the genetic component of obesity.
|
21233811 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no statistical association between A46G and hypertension risk in all subjects, Asians or Caucasians.
|
20739939 |
2010 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
β2-adrenoceptor (β2AR) gene polymorphism glutamine 27 glutamic acid (Gln27Glu) and Arg16Gly were reported to have an association with obesity and obesity related disorders in some population.
|
20738880 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We revealed that a combination of the Arg16Gly and Glu298Asp polymorphisms in ADRB2 and NOS3, respectively, remarkably increased the risk for hypertension in middle-aged and elderly humans.
|
19373110 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Early studies suggest that bronchodilator reversibility and asthma worsening in patients on continuous short-acting and long-acting beta-agonists are related to the Gly16Arg genotype for the ADRB2.
|
19077707 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aims of this study were: (1) to find associations of asthma with single-nucleotide polymorphisms (SNPs) within the ADRB2 gene: Arg16Gly, Gln27Glu, -1023 G/A, -367 T/C, -47 C/T ; (2) to define linkage disequilibrium in the gene region, basing on the analyzed SNPs; and (3) to analyze the importance of ADRB2 polymorphism for response to bronchodilator drugs in children diagnosed with bronchial asthma.
|
19638684 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Eleven single nucleotide polymorphisms (SNPs) in CHRM1-3 (coding muscarinic receptors one to three) which were identified by re-sequencing, and Arg16Gly and Gln27Glu in ADRB2 (coding beta(2) adrenoreceptor) were scored in 80 of the 138 asthmatics.
|
19183167 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors analyze the possible implication of 7 genetic polymorphisms described as asthma susceptibility genes: IL13 (C-1112T and R130Q), IL4RA (I50V, Q551R), IL5 (C-746T) and ADRB2 (Q27E and R16G) in specific olive pollen allergic sensitization.
|
18849614 |
2009 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The summary odds ratio (OR) from overall analyses showed no association between either rs1042714 or rs1042713 and obesity.
|
19186333 |
2008 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ADRbeta2 variations Gly(16)Arg and Gln(27)Glu and, more recently, haplotypic variations, have been the focus of numerous pharmacogenetic studies looking at responses to short-acting (SABA) and long-acting beta-agonists (LABA) in subjects with asthma.
|
18303970 |
2008 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Analyses from this study indicate that genetic polymorphisms leading to Arg16Gly sequence changes within the beta2-adrenergic receptor do not affect patients' responses to recommended asthma therapy with salmeterol and fluticasone propionate.
|
17030231 |
2006 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we examined the variability of definitions of endpoints and analyses reported across studies addressing the association of the Arg16Gly and/or Gln27Glu polymorphisms of the beta2-adrenergic receptor gene with clinical response to beta2-agonist therapy in asthma.
|
17001289 |
2006 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not observe association of the SNP +46 (Arg16Gly) variant with asthma disease diagnosis and asthma-related phenotypes.
|
16596417 |
2006 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Ethnic-specific pharmacogenetic differences exist between Arg16Gly genotypes, asthma severity, and bronchodilator response in Puerto Ricans and Mexicans with asthma.
|
15557128 |
2005 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A number of studies have investigated two common polymorphisms in the beta(2)-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility.
|
15987731 |
2005 |