|
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
In conclusion, genotypic polymorphisms of the eNOS Glu298Asp and Cav-1 14713A/29107A polymorphisms are associated with the elevated risk of LAA stroke among Han Chinese in Taiwan.
|
28346478 |
2017 |
|
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
In pooled analysis of all patients, intron 4c, but not intron 4a, intron 4b or G894T alleles are associated with stroke (p < 0.01).
|
18070351 |
2007 |
|
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
Thus, we examined the possible association of eNOS G894T variation with stroke severity and functional outcome.
|
22004707 |
2011 |
|
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
We identified an exonic polymorphism in NOS3 (rs1799983, p.Glu298Asp; p = 2.2E-8, odds ratio [OR] = 1.05, 95% confidence interval [CI] = 1.04-1.07) and variants in an intron of COL4A1 (rs9521634; p = 3.8E-8, OR = 1.04, 95% CI = 1.03-1.06) and near DYRK1A (rs720470; p = 6.1E-9, OR = 1.05, 95% CI = 1.03-1.07) at genome-wide significance for stroke.
|
30383316 |
2018 |
|
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004).
|
26256966 |
2015 |
|
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
However, the copresence of G894T and intron 4 VNTR risk-elevating genotypes in the same individual increased the risk of stroke seven times (odds ratio=7.083, 95% confidence interval=0.866-57.963, p=0.029).
|
25321404 |
2014 |
|
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
In order to investigate the influence of genetic factors in childhood stroke, we compared the distributions of mutations/ polymorphisms affecting hemostasis and/or endothelial function (factor V [FV] Leiden, factor II [FII] G20210A, methylenetetrahydrofolate reductase [MTHFR] C677T, angiotensin-converting enzyme [ACE] insertion/deletion [ID], and endothelial nitric oxide synthase [eNOS] G894T) among children with stroke and controls.
|
19372095 |
2009 |
|
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
We tested a single nucleotide polymorphism (SNP) in endothelial nitric oxide synthase (NOS3) gene at codon 298 (single-nucleotide polymorphism rs1799983; p.Asp298Glu) in a cohort of 355 older (>75 years) stroke survivors, who had detailed cognitive assessments from 3 months poststroke, i.e., baseline when the patients were free of dementia and subsequently at annual intervals.
|
20691505 |
2011 |
|
Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess the role of the endothelial nitric oxide synthase (eNOS) gene variants as risk factors for early atherosclerosis, we sought to investigate whether two polymorphisms located in the exon 7 (Glu298-->Asp) and in the promoter region (T-786-->C) of the eNOS gene were associated with functional changes in the endothelium and carotid intima-media thickness (IMT).
|
15073390 |
2004 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu-298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease.
|
10475066 |
1999 |
|
Erectile dysfunction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Logistic regression analysis showed that G894T polymorphism was an independent risk factor for ED.
|
19473288 |
2009 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls.
|
16616056 |
2006 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease.
|
24827774 |
2014 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a subgroup analysis adjusted with various cardiovascular risk factors confirmed positive association of the -786T>C polymorphism in CAD patients with hypertension and a smoking history and also a significant association of the intron 4 genotypes with a smoking history, but no significance has been found in the eNOS polymorphisms of 894G>T upon any risk adjustment.
|
16842840 |
2007 |
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
It was found that, compared with -786TT, the -786C variant genotypes were associated with a significantly increased risk of breast cancer in an allele dose-dependent manner (adjusted odds ratio [OR], 1.33 [95% confidence interval (95% CI)], 0.99-1.77 for -786TC; and OR, 1.79 [95% CI, 1.11-2.87] for -786CC; P(trend) = .007), but 27-bp VNTR and 894G>T genotypes were not.
|
17063466 |
2006 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a Glu298Asp variant of the endothelial nitric oxide synthase gene (NOS3) was identified as being associated with coronary spasm and myocardial infarction, whereas it has been reported that endothelial nitric oxide synthase plays a role in HP.
|
11745998 |
2001 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease.
|
14989558 |
2003 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Indeed, a missense mutation in the endothelial NO gene caused by a Glu298Asp alteration has been strongly associated with essential hypertension, coronary artery spasm, and myocardial infarction.
|
11967250 |
2002 |
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the protective HO1 promoter polymorphism correlates with a lower coronary artery plaque burden, whereas the protective ENOS 894 G/T polymorphism seems to favourably influence changes of coronary artery plaque composition during statin therapy, but has no significant correlation to the magnitude of coronary atherosclerosis.
|
22123460 |
2011 |
|
Chronic kidney disease stage 5
|
|
0.100 |
GeneticVariation
|
BEFREE |
Impact of nitric oxide synthase Glu298Asp polymorphism on the development of end-stage renal disease in type 2 diabetic Egyptian patients.
|
21854353 |
2011 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study indicates that E298D polymorphism of the eNOS gene seems to be associated with MI occurrence in the Greek population.
|
20854685 |
2010 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The eNOS G894T or eNOS 894TT genotypes in combination with the MTHFR 677TT or ACE D/D genotype increases the risk of ischaemic stroke.
|
15595935 |
2005 |
|
Diabetic Nephropathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, a case-control study was carried out to investigate the effects of 7 SNPs in ACE gene and 2 SNPs in eNOS gene in the development of DN in Northern China.7 SNPs including A240T, A2350G, A5466C, A2215G, T3892C, C1237T and C3409T of ACE gene and 2 SNPs (G894T and T786C) of eNOS gene were genotyped by polymerase chain reaction restriction fragment length polymorphism method.
|
25227524 |
2015 |
|
Chronic kidney disease stage 5
|
|
0.100 |
GeneticVariation
|
BEFREE |
Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.
|
16364824 |
2005 |