|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a significant association of the missense Glu298Asp variant of the eNOS gene with MI.
|
9626827 |
1998 |
|
Coronary Artery Vasospasm
|
|
0.060 |
GeneticVariation
|
BEFREE |
Recently, we reported that a missense Glu298Asp variant in exon 7 of the eNOS gene is a possible genetic factor involved in the pathogenesis of coronary spasm.
|
9626827 |
1998 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have identified a missense variant, Glu298Asp, in exon 7 of the eNOS gene and demonstrated that it is associated with both coronary spastic angina and myocardial infarction.
|
9674630 |
1998 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the Glu298Asp missense variant was significantly associated with essential hypertension, which suggests that it is a genetic susceptibility factor for essential hypertension.
|
9674630 |
1998 |
|
Coronary spastic angina
|
|
0.020 |
GeneticVariation
|
BEFREE |
We have identified a missense variant, Glu298Asp, in exon 7 of the eNOS gene and demonstrated that it is associated with both coronary spastic angina and myocardial infarction.
|
9674630 |
1998 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a common polymorphism in exon 7 of the eNOS gene (894G-->T) has been reported to be a strong risk factor for coronary artery disease.
|
9731617 |
1998 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a common polymorphism in exon 7 of the eNOS gene (894G-->T) has been reported to be a strong risk factor for coronary artery disease.
|
9731617 |
1998 |
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a common polymorphism in exon 7 of the eNOS gene (894G-->T) has been reported to be a strong risk factor for coronary artery disease.
|
9731617 |
1998 |
|
Coronary Artery Vasospasm
|
|
0.060 |
GeneticVariation
|
BEFREE |
After initial screening in the entire 26 coding regions of the eNOS gene, we found a missense Glu298Asp variant in exon 7 in patients with coronary spasm.
|
9737779 |
1998 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relevance of the Glu298Asp polymorphism to hypertension in this population was tested in 2 ways.
|
10205226 |
1999 |
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant association between a Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene and essential hypertension was recently reported in Japanese populations, with the 298Asp variant showing a higher prevalence in hypertensive patients (10.3% to 12.0%) than in normotensive subjects (5.0% to 5.8%).
|
10205226 |
1999 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A missense mutation of the nitric oxide synthase (eNOS) gene (Glu298Asp) in five patients with coronary artery disease--case reports.
|
10451235 |
1999 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A missense mutation of the nitric oxide synthase (eNOS) gene (Glu298Asp) in five patients with coronary artery disease--case reports.
|
10451235 |
1999 |
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A missense mutation of the nitric oxide synthase (eNOS) gene (Glu298Asp) in five patients with coronary artery disease--case reports.
|
10451235 |
1999 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu-298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease.
|
10475066 |
1999 |
|
Atherosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined associations between the endothelial nitric oxide synthase (eNOS) gene Glu-298-->Asp (894G-->T) mutation and the occurrence and severity of angiographically defined coronary artery disease (CAD). eNOS mediates basal vascular wall nitric oxide production, and altered nitric oxide production has been implicated in atherosclerosis.
|
10475066 |
1999 |
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu-298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease.
|
10475066 |
1999 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the eNOS Glu-298-->Asp mutation is common, occurring with an allele frequency of 32.5%, but is not associated with either the occurrence or severity of CAD in the Australian population or with other established coronary risk factors assessed in our study.
|
10475066 |
1999 |
|
Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined associations between the endothelial nitric oxide synthase (eNOS) gene Glu-298-->Asp (894G-->T) mutation and the occurrence and severity of angiographically defined coronary artery disease (CAD). eNOS mediates basal vascular wall nitric oxide production, and altered nitric oxide production has been implicated in atherosclerosis.
|
10475066 |
1999 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for a common NOS 3 polymorphism (894 G-->T) which encodes a Glu298-->Asp amino acid substitution in eNOS is a risk factor for angiographic CAD and recent MI in this population.
|
10510054 |
1999 |
|
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK.
|
10510054 |
1999 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK.
|
10510054 |
1999 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for a common NOS 3 polymorphism (894 G-->T) which encodes a Glu298-->Asp amino acid substitution in eNOS is a risk factor for angiographic CAD and recent MI in this population.
|
10510054 |
1999 |
|
Cor pulmonale
|
|
0.010 |
GeneticVariation
|
BEFREE |
An endothelial nitric oxide synthase (eNOS) polymorphism in exon 7 (894 G/T) resulting in glutamate or aspartate, respectively, at position 298 on the protein is correlated with severity of cardiopulmonary diseases.
|
10717002 |
2000 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Glu298Asp variant may be a genetic susceptibility factor for hypertension.
|
10883733 |
2000 |