rs1799983, NOS3

N. diseases: 246
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Deep Vein Thrombosis
CUI: C0149871
Disease: Deep Vein Thrombosis
0.020 GeneticVariation BEFREE -922A/G shows both genotypic (P=0.0218; chi2=5.25; O.R=1.94) as well as allelic association (P=0.0014; chi2=10.19; O.R=2.0) while 894G/T shows only allelic (P=0.04; chi2=3.93; O.R=3.93) association with DVT. 20114041 2010
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease. 16364824 2005
Atherosclerosis
CUI: C0004153
Disease: Atherosclerosis
0.100 GeneticVariation BEFREE Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease. 16364824 2005
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE Diabetes mellitus and late-onset hypogonadism: the role of Glu298Asp endothelial nitric oxide synthase polymorphism. 25228279 2015
Septicemia
CUI: C0036690
Disease: Septicemia
0.030 GeneticVariation BEFREE Sepsis independently associated with HF, increased NOx, peripheral neutrophils, and fibrinogen levels, decreased prothrombin and the presence of the NOS3 (E298D) and NOS2A (exon 22) SNPs. 25239655 2014
Sepsis
CUI: C0243026
Disease: Sepsis
0.030 GeneticVariation BEFREE Sepsis independently associated with HF, increased NOx, peripheral neutrophils, and fibrinogen levels, decreased prothrombin and the presence of the NOS3 (E298D) and NOS2A (exon 22) SNPs. 25239655 2014
Heart failure
CUI: C0018801
Disease: Heart failure
0.060 GeneticVariation BEFREE Heart failure and endothelial nitric oxide synthase G894T gene polymorphism frequency variations within ancestries. 28554876 2018
Congestive heart failure
CUI: C0018802
Disease: Congestive heart failure
0.060 GeneticVariation BEFREE Heart failure and endothelial nitric oxide synthase G894T gene polymorphism frequency variations within ancestries. 28554876 2018
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Glu298-->Asp polymorphism of the eNOS gene appears to be associated with the presence, extent, and severity of angiographically assessed coronary artery disease. 12010932 2002
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.100 GeneticVariation BEFREE Glu298-->Asp polymorphism of the eNOS gene appears to be associated with the presence, extent, and severity of angiographically assessed coronary artery disease. 12010932 2002
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.100 GeneticVariation BEFREE Glu298-->Asp polymorphism of the eNOS gene appears to be associated with the presence, extent, and severity of angiographically assessed coronary artery disease. 12010932 2002
Myocardial Infarction
CUI: C0027051
Disease: Myocardial Infarction
0.100 GeneticVariation BEFREE G894T polymorphism on the eNOS gene increases the risk for premature MI and modifies the response of vascular endothelium during the acute phase of MI by affecting the release of vWF, IL-6, and oxidative stress status, an effect diminished one year after the event. 16168297 2005
Behcet Syndrome
CUI: C0004943
Disease: Behcet Syndrome
0.070 GeneticVariation BEFREE Glu298 --> Asp polymorphism of the eNOS gene does not appear to be associated with the presence of BD in the Turkish population. 16463158 2006
Encephalitis, St. Louis
CUI: C0014060
Disease: Encephalitis, St. Louis
0.010 GeneticVariation BEFREE Glu298Asp eNOS polymorphism is not associated with SLE. 19318399 2009
Foot Ulcer
CUI: C0085119
Disease: Foot Ulcer
0.010 GeneticVariation BEFREE G894T polymorphism of eNOS gene was not associated with foot ulcer and diabetic complications, except in the presence of atherosclerotic heart disease. 20642368 2010
Complications of Diabetes Mellitus
CUI: C0342257
Disease: Complications of Diabetes Mellitus
0.020 GeneticVariation BEFREE G894T polymorphism of eNOS gene was not associated with foot ulcer and diabetic complications, except in the presence of atherosclerotic heart disease. 20642368 2010
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.100 GeneticVariation BEFREE G894T polymorphism of eNOS gene was not associated with foot ulcer and diabetic complications, except in the presence of atherosclerotic heart disease. 20642368 2010
Eclampsia
CUI: C0013537
Disease: Eclampsia
0.060 GeneticVariation BEFREE Glu298Asp polymorphism in the eNOS gene could be an individual's risk factor and may modulate progression to an eclampsia complication of preeclampsia in the Turkish population. 21793998 2011
Hypertensive disease
CUI: C0020538
Disease: Hypertensive disease
0.100 GeneticVariation BEFREE Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. 21816783 2011
Coronary Arteriosclerosis
CUI: C0010054
Disease: Coronary Arteriosclerosis
0.100 GeneticVariation BEFREE Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. 21816783 2011
Coronary Artery Disease
CUI: C1956346
Disease: Coronary Artery Disease
0.100 GeneticVariation BEFREE Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. 21816783 2011
Coronary heart disease
CUI: C0010068
Disease: Coronary heart disease
0.100 GeneticVariation BEFREE Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. 21816783 2011
Asthma
CUI: C0004096
Disease: Asthma
0.060 GeneticVariation BEFREE G894T and -786T/C polymorphisms were not associated with asthma susceptibility. 22966886 2012
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE G894T polymorphism was associated with DN only in allele contrast and in co-dominance model. 24433471 2014
Malignant neoplasm of breast
CUI: C0006142
Disease: Malignant neoplasm of breast
0.100 GeneticVariation BEFREE This meta-analysis indicated that the eNOS T-786C polymorphism is associated with elevated cancer risk; the G894T polymorphism contributes to susceptibility to breast cancer and cancer generally in females; and the 4a/b polymorphism may be associated with prostate cancer risk. 25040995 2014