rs4420638, APOC1

N. diseases: 43
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
C-reactive protein measurement
CUI: C0201657
Disease: C-reactive protein measurement
0.800 GeneticVariation GWASCAT Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. 27286809 2016
High density lipoprotein measurement
CUI: C0392885
Disease: High density lipoprotein measurement
0.800 GeneticVariation GWASCAT Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. 27286809 2016
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. 27286809 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASDB Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. 17998437 2008
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASCAT Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. 17998437 2008
Low density lipoprotein cholesterol measurement
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
0.800 GeneticVariation GWASDB Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. 18802019 2008
Low density lipoprotein cholesterol measurement
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
0.800 GeneticVariation GWASCAT Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. 18802019 2008
Serum LDL cholesterol measurement
CUI: C0428474
Disease: Serum LDL cholesterol measurement
0.700 GeneticVariation GWASDB Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. 18802019 2008
Low density lipoprotein cholesterol measurement
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
0.800 GeneticVariation GWASDB Common variants at 30 loci contribute to polygenic dyslipidemia. 19060906 2009
Low density lipoprotein cholesterol measurement
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
0.800 GeneticVariation GWASCAT Common variants at 30 loci contribute to polygenic dyslipidemia. 19060906 2009
Serum LDL cholesterol measurement
CUI: C0428474
Disease: Serum LDL cholesterol measurement
0.700 GeneticVariation GWASDB Common variants at 30 loci contribute to polygenic dyslipidemia. 19060906 2009
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841 2011
High density lipoprotein measurement
CUI: C0392885
Disease: High density lipoprotein measurement
0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2013
Serum total cholesterol measurement
CUI: C1445957
Disease: Serum total cholesterol measurement
0.800 GeneticVariation GWASCAT Discovery and refinement of loci associated with lipid levels. 24097068 2013
Low density lipoprotein cholesterol measurement
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2013
High density lipoprotein measurement
CUI: C0392885
Disease: High density lipoprotein measurement
0.800 GeneticVariation GWASCAT Discovery and refinement of loci associated with lipid levels. 24097068 2013
Serum total cholesterol measurement
CUI: C1445957
Disease: Serum total cholesterol measurement
0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2013
Low density lipoprotein cholesterol measurement
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
0.800 GeneticVariation GWASCAT Discovery and refinement of loci associated with lipid levels. 24097068 2013
Serum LDL cholesterol measurement
CUI: C0428474
Disease: Serum LDL cholesterol measurement
0.700 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2013
Serum HDL cholesterol measurement
CUI: C0428472
Disease: Serum HDL cholesterol measurement
0.700 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2013
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.820 GeneticVariation GWASCAT Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer's disease with OSBPL6, PTPRG, and PDCL3. 26830138 2016
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.710 GeneticVariation BEFREE Following regression analysis adjusted by collection center, gender, duration of diabetes, and average HbA1c, two SNPs were significantly associated with DN. rs4420638 in the APOC1 region (odds ratio [OR] = 1.51; confidence intervals [CI]: 1.19-1.91; P = 0.001) and rs1532624 in CETP (OR = 0.82; CI: 0.69-0.99; P = 0.034); rs4420638 was also significantly associated in a sensitivity analysis (P = 0.016) together with rs7679 (P = 0.027). 23555584 2013
Diabetes
CUI: C0011847
Disease: Diabetes
0.710 GeneticVariation BEFREE Following regression analysis adjusted by collection center, gender, duration of diabetes, and average HbA1c, two SNPs were significantly associated with DN. rs4420638 in the APOC1 region (odds ratio [OR] = 1.51; confidence intervals [CI]: 1.19-1.91; P = 0.001) and rs1532624 in CETP (OR = 0.82; CI: 0.69-0.99; P = 0.034); rs4420638 was also significantly associated in a sensitivity analysis (P = 0.016) together with rs7679 (P = 0.027). 23555584 2013
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.010 GeneticVariation BEFREE Following regression analysis adjusted by collection center, gender, duration of diabetes, and average HbA1c, two SNPs were significantly associated with DN. rs4420638 in the APOC1 region (odds ratio [OR] = 1.51; confidence intervals [CI]: 1.19-1.91; P = 0.001) and rs1532624 in CETP (OR = 0.82; CI: 0.69-0.99; P = 0.034); rs4420638 was also significantly associated in a sensitivity analysis (P = 0.016) together with rs7679 (P = 0.027). 23555584 2013
Low density lipoprotein cholesterol measurement
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019