|
Carcinoma of bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found that the A allele of rs699947 and the A allele of rs833052 within VEGF gene, interaction between rs2010963 and smoking, haplotype containing the rs2010963- C and rs833052- A alleles were all associated with increased bladder cancer risk.
|
28206971 |
2017 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We were unable to find strong association between analyzed polymorphisms in growth factors and the severity of coronary artery disease, although there was a trend toward association between rs699947 and the severity of CAD in patients without previous MI.
|
27835972 |
2016 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
By stratified analysis, AA genotype of rs699947 was associated with an increased risk of osteosarcoma in those with shorter age, males and a family history of cancer, and GG genotype of rs2010963 was correlated with an increased risk of osteosarcoma in those with shorter age, females and a family history of cancer.
|
25550863 |
2014 |
|
Bladder Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
In summary, our study showed evidence that the VEGF rs699947 polymorphism was obviously associated with an increased risk of bladder cancer and renal cell carcinoma, particularly in Asian population, while no significant association was observed in overall urologic neoplasms.
|
30195633 |
2018 |
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results seem to indicate that combining information from genotyping of rs699947 (VEGFA, AC), rs2269772 (ITGA, AA) and tumour histology could allow clinicians to individuate gastric cancer at high risk for recurrence either with peritoneal or hematogenous metastases.
|
22808003 |
2012 |
|
Bladder Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
As to ethnicity subgroup analysis, rs699947 and rs3025039 polymorphisms were thought as a risk factor for BCa risk in Asian population, while a decreased association was revealed between rs699947 (C > A) A-allele and BCa risk in African population under dominant, recessive, homozygous, heterozygous and allele contrast genetic models.
|
30849545 |
2019 |
|
Malignant neoplasm of urinary bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
As to ethnicity subgroup analysis, rs699947 and rs3025039 polymorphisms were thought as a risk factor for BCa risk in Asian population, while a decreased association was revealed between rs699947 (C > A) A-allele and BCa risk in African population under dominant, recessive, homozygous, heterozygous and allele contrast genetic models.
|
30849545 |
2019 |
|
Malignant neoplasm of urinary bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found that the A allele of rs699947 and the A allele of rs833052 within VEGF gene, interaction between rs2010963 and smoking, haplotype containing the rs2010963- C and rs833052- A alleles were all associated with increased bladder cancer risk.
|
28206971 |
2017 |
|
Carcinoma of bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
In summary, our study showed evidence that the VEGF rs699947 polymorphism was obviously associated with an increased risk of bladder cancer and renal cell carcinoma, particularly in Asian population, while no significant association was observed in overall urologic neoplasms.
|
30195633 |
2018 |
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Variant genotypes of rs699947 (CA + AA) were significantly associated with high-grade (G2 + G3) tumors (OR = 1.82; 95% CI = 1.15 - 2.89), and with shorter disease-free survival among patients treated with neoadjuvant chemotherapy followed by mastectomy (HRadjusted = 1.82; 95% CI = 1.16 - 2.86).
|
27195611 |
2016 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, subgroup analysis based on cancer types demonstrated that significantly increased association was found between VEGF rs699947 polymorphism and the risk of bladder cancer (BCa) under heterozygous genetic model (OR = 1.48, 95%CI = 1.17-1.89).
|
30195633 |
2018 |
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Moreover, VEGF rs699947 and rs2010963 polymorphisms may serve as genetic biomarkers of poor collateral circulation after myocardial ischemia.
|
30317903 |
2018 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
Four polymorphisms of the above excluding rs699947 and rs3025039 showed significant association with malignancy, and we observed the presence of positive correlation between haplotype CCGGCC and increased expression of VEGF-A in both plasma and tissues which also correlated with poor prognosis and recurrence suggesting a probable increase in resistance to treatment in such carriers.
|
26264619 |
2016 |
|
Carcinoma of bladder
|
|
0.030 |
GeneticVariation
|
BEFREE |
As to ethnicity subgroup analysis, rs699947 and rs3025039 polymorphisms were thought as a risk factor for BCa risk in Asian population, while a decreased association was revealed between rs699947 (C > A) A-allele and BCa risk in African population under dominant, recessive, homozygous, heterozygous and allele contrast genetic models.
|
30849545 |
2019 |
|
Malignant Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Four polymorphisms of the above excluding rs699947 and rs3025039 showed significant association with malignancy, and we observed the presence of positive correlation between haplotype CCGGCC and increased expression of VEGF-A in both plasma and tissues which also correlated with poor prognosis and recurrence suggesting a probable increase in resistance to treatment in such carriers.
|
26264619 |
2016 |
|
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genomic DNA was isolated from whole blood for the analysis of <i>VEGF-A</i> (rs2010963, 1570360, rs699947), <i>ICAM-1</i> (rs5498, rs1799969) SNPs and from tumor tissue for the detection of genomic variants in <i>KRAS</i>, <i>NRAS</i>, <i>BRAF</i> genes.
|
31752122 |
2019 |
|
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, subgroup analysis based on cancer types demonstrated that significantly increased association was found between VEGF rs699947 polymorphism and the risk of bladder cancer (BCa) under heterozygous genetic model (OR = 1.48, 95%CI = 1.17-1.89).
|
30195633 |
2018 |
|
Bladder Neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
We found that the A allele of rs699947 and the A allele of rs833052 within VEGF gene, interaction between rs2010963 and smoking, haplotype containing the rs2010963- C and rs833052- A alleles were all associated with increased bladder cancer risk.
|
28206971 |
2017 |
|
Coronary Arteriosclerosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined two VEGF polymorphisms, including +405 C/G (rs2010963) and -2578C/A (rs699947), to assess their relation to the extent of coronary atherosclerosis.
|
20489684 |
2010 |
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Compared with the G allele, the A allele of rs699947 was associated with a significantly increased risk of cervical cancer in subjects above 20 years and who were positive for human papillomavirus 16 (HPV-16) or HPV-18 infection.
|
26535675 |
2015 |
|
Malignant neoplasm of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
rs833061 and rs699947 on promoter gene of vascular endothelial growth factor (VEGF) and associated lung cancer susceptibility and survival: a meta-analysis.
|
25468805 |
2014 |
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Specific VEGF variants (rs699947, rs1570360) and haplotype (CTGCCAG) may contribute to the development of CC among Tunisian women.
|
25541433 |
2015 |
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) gene polymorphisms are not associated with AMD susceptibility in a Spanish population.
|
23971975 |
2013 |
|
Retinal Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found a significant association between the A allele at rs699947 with DR (odds ratio = 1.84 (95% confidence interval = 1.28-2.66); P = 0.001 vs. noDR).
|
20444917 |
2010 |