|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates the CD226 rs763361 polymorphism confers susceptibility to autoimmune disease in Europeans, South Americans and Asians, and in particular, shows that the CD226 rs763361 polymorphism is associated with SLE, SSc and T1D.
|
22941566 |
2012 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
A novel non-synonymous (Gly307Ser) variant, rs763361, of the CD226 gene on chromosome 18q22 was recently shown to be associated with multiple autoimmune diseases.
|
20887380 |
2011 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
The nonsynonymous polymorphism rs763361 of the CD226 gene, which encodes DNAX accessory molecule 1, which is involved in T cell costimulation pathways, has recently been identified as a genetic risk factor for autoimmunity.
|
21162102 |
2011 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
A nonsynonymous polymorphism in exon 7 of the gene encoding the lymphocyte cell-surface CD226 (DNAM1) receptor, Gly307Ser (rs763361), has recently been identified as conferring risk to many autoimmune disorders.
|
21521299 |
2011 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.
|
20338887 |
2010 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
CD226 Gly307Ser association with multiple autoimmune diseases.
|
18971939 |
2009 |
|
Autoimmune Diseases
|
|
0.090 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence that a non-synonymous exchange (Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including type 1 diabetes, multiple sclerosis (MS), rheumatoid arthritis and Grave's disease.
|
19536154 |
2009 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
An association of STAT4 (rs10181656) with PsA was confirmed whereas CD226 (rs763361) was associated with PsA but not with RA, in contrast to previous reports.
|
27440135 |
2017 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our meta-analysis demonstrates that the CD226 rs763361 and FASL rs763110 polymorphisms are associated with RA, especially in Asians.
|
25645050 |
2015 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis, and primary sicca syndrome (pSS).
|
23073294 |
2013 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Disease-specific meta-analysis showed an association between systemic lupus erythematosus (SLE) and the CD226 rs763361 T allele (OR 1.150, 95% CI 1.040-1.271, p = 0.006), but no association between rheumatoid arthritis and the CD226 rs763361 polymorphism (OR for the T allele 1.207, 95% CI 0.913-1.596, p = 0.187).
|
22941566 |
2012 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Meta-analysis confirms the association between rs763361 and RA (overall P < 0.001, overall odds ratio = 1.12).
|
21286723 |
2012 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence that a non-synonymous exchange (Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including type 1 diabetes, multiple sclerosis (MS), rheumatoid arthritis and Grave's disease.
|
19536154 |
2009 |
|
Rheumatoid Arthritis
|
|
0.080 |
GeneticVariation
|
BEFREE |
In addition to the analysis of newly available samples in T1D (2088 cases and 3289 controls) and autoimmune thyroid disease (AITD) (821 cases and 1920 controls), resulting in strong support for the Ser(307) association with T1D (P=3.46 x 10(-9)) and continued potential evidence for AITD (P=0.0345), we provide evidence for association of Gly307Ser with MS (P=4.20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017).
|
18971939 |
2009 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
We also confirmed the association of <i>CD226</i> locus with SLE (rs763361, p<sub>meta</sub>=2.45E-08).
|
29625966 |
2018 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
Our results support an important association of rs4810485 in CD40 gene and rs76</span>3361 in CD226 gene polymorphism, combined effect of rs4810485 and rs763361 with increased risk of SLE.
|
27722794 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates the CD226 rs763361 polymorphism confers susceptibility to autoimmune disease in Europeans, South Americans and Asians, and in particular, shows that the CD226 rs763361 polymorphism is associated with SLE, SSc and T1D.
|
22941566 |
2012 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
|
Lupus Erythematosus, Systemic
|
|
0.050 |
GeneticVariation
|
BEFREE |
A 3-variant haplotype, rs763361;rs34794968;rs727088 (ATC), in the last exon of CD226 was associated with SLE (P = 1.3 × 10(-4) , odds ratio 1.24, 95% confidence interval 1.11-1.38).
|
20669283 |
2010 |
|
Systemic Scleroderma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Furthermore, association analysis of the genotypes with clinical manifestations of the disease revealed that rs763361 variants were associated with the forced vital capacity (FVC) in SSc patients.
|
29338153 |
2017 |
|
Systemic Scleroderma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not.
|
28434122 |
2017 |
|
Systemic Scleroderma
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrates the CD226 rs763361 polymorphism confers susceptibility to autoimmune disease in Europeans, South Americans and Asians, and in particular, shows that the CD226 rs763361 polymorphism is associated with SLE, SSc and T1D.
|
22941566 |
2012 |
|
Systemic Scleroderma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The CD226 rs763361 T allele was found to be associated with SSc in both the discovery and the replication samples, showing the following results in the combined populations: odds ratio (OR) 1.22 (95% confidence interval [95% CI] 1.10-1.34), P = 5.69 × 10(-5) .
|
21162102 |
2011 |
|
Graves Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis, and primary sicca syndrome (pSS).
|
23073294 |
2013 |