|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The MEDLINE and EMBASE databases were searched for studies reporting on the association between GCKR variants (rs1260326, rs780094, and rs780093) and coronary artery disease (CAD), estimated glomerular filtration rate (eGFR), and chronic kidney disease (CKD).
|
30352097 |
2018 |
|
Hyperglycemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The C allele of rs780094 was associated with lower lactate levels in fasting but increased lactate level during hyperglycemia independently of insulin levels.
|
30375486 |
2018 |
|
Chronic Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The MEDLINE and EMBASE databases were searched for studies reporting on the association between GCKR variants (rs1260326, rs780094, and rs780093) and coronary artery disease (CAD), estimated glomerular filtration rate (eGFR), and chronic kidney disease (CKD).
|
30352097 |
2018 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, we provided direct evidence that the copy number, but not the genotype of the CNV in the genomic regions of rs780094(GCKR) is associated with low level of high-density lipoprotein cholesterol in PCOS.
|
27878529 |
2017 |
|
Spina Bifida
|
|
0.010 |
GeneticVariation
|
BEFREE |
The AA genotype in maternal GCKR rs780094 is associated with an increased risk for NTDs and spina bifida in the Chinese population.
|
25369983 |
2015 |
|
Neural Tube Defects
|
|
0.010 |
GeneticVariation
|
BEFREE |
The AA genotype in maternal GCKR rs780094 is associated with an increased risk for NTDs and spina bifida in the Chinese population.
|
25369983 |
2015 |
|
Fibrosis, Liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
In patients with NAFLD, GCKR rs780094 C>T is associated with the severity of liver fibrosis and with higher serum triglyceride levels.
|
24498332 |
2014 |
|
Fatty Liver Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study suggests that risk allele T of the GCKR rs780094 and rs1260326 is associated with predisposition to NAFLD and NASH with significant fibrosis.
|
23800943 |
2014 |
|
Nonalcoholic Steatohepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GCKR rs1260326 and rs780094 allele T were associated with susceptibility to NAFLD (OR 1.49, 95 % CI 1.09-2.05, p = 0.012; and OR 1.51, 95 % CI 1.09-2.09, p = 0.013, respectively), non-alcoholic steatohepatitis (NASH) (OR 1.55, 95 % CI 1.10-2.17, p = 0.013; and OR 1.56, 95 % CI 1.10-2.20, p = 0.012, respectively) and NASH with significant fibrosis (OR 1.50, 95 % CI 1.01-2.21, p = 0.044; and OR 1.52, 95 % CI 1.03-2.26, p = 0.038, respectively).
|
23800943 |
2014 |
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study provides the first evidence that GCKR rs780094, a single-nucleotide polymorphism related to diabetes, may be associated with pancreatic cancer risk.
|
22015968 |
2012 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation
|
BEFREE |
Future studies attempting to replicate the association between the GCKR rs780094 variant and the risk of colorectal cancer are warranted.
|
22354904 |
2012 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Future studies attempting to replicate the association between the GCKR rs780094 variant and the risk of colorectal cancer are warranted.
|
22354904 |
2012 |
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study provides the first evidence that GCKR rs780094, a single-nucleotide polymorphism related to diabetes, may be associated with pancreatic cancer risk.
|
22015968 |
2012 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study.
|
20661421 |
2010 |
|
Fatty Liver
|
|
0.020 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants were independent risk factors of hepatic steatosis and elevated ALT levels.
|
29314568 |
2018 |
|
Fatty Liver
|
|
0.020 |
GeneticVariation
|
BEFREE |
We used data from the National Health and Nutrition Examination Survey III to validate the association between rs738409 (PNPLA3), rs780094 (GCKR), and rs4240624 (PPP1R3B) with HS, with or without increased levels of ALT, among 3 different ancestries.
|
23416328 |
2013 |
|
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results of this population-based study provide evidence for a relationship between lipid regulatory gene polymorphisms including GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) with dyslipidemia in an Iranian population.
|
29858861 |
2018 |
|
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
Ga allele of GCKR (rs780094) SNPs had a protective effect on obesity.
|
29531563 |
2018 |
|
Steatohepatitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
PNPLA3 rs738409, GCKR rs780094 and TM6SF2 rs58542926 variants were independent risk factors of hepatic steatosis and elevated ALT levels.
|
29314568 |
2018 |
|
Steatohepatitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype.
|
24498332 |
2014 |
|
Steatohepatitis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We used data from the National Health and Nutrition Examination Survey III to validate the association between rs738409 (PNPLA3), rs780094 (GCKR), and rs4240624 (PPP1R3B) with HS, with or without increased levels of ALT, among 3 different ancestries.
|
23416328 |
2013 |
|
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
Results of logistic regression revealed that, despite higher triglyceride levels, the carriers of the GCKR variants were more protected against the development of obesity; the adjusted models confirmed the lower risk of obesity for both variants (rs1260326: OR, 0.46; 95% CI, 0.25-0.83; rs780094: OR, 0.41; 95% CI, 0.23-0.74).
|
21511510 |
2011 |
|
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
The GCKR rs780094 was also associated with obesity and BMI, independently of its association with type 2 diabetes.
|
19241058 |
2009 |
|
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals.
|
19241058 |
2009 |
|
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01).
|
18008060 |
2008 |