Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 72 928
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 95 596
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
CHEK2 O96017 checkpoint kinase 2 Kinase 1.2E-24 0.460 0.808 47 223
CDH1 P12830 cadherin 1 0.15 0.401 0.808 73 158
MUTYH Q9UIF7 mutY DNA glycosylase Enzyme 1.3E-18 0.521 0.769 19 144
SMAD4 Q13485 SMAD family member 4 Transcription factor 1.00 0.401 0.808 47 136
PAX6 P26367 paired box 6 1.00 0.450 0.769 55 109
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 93 98
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
DPYD Q12882 dihydropyrimidine dehydrogenase Enzyme 3.4E-22 0.493 0.846 45 78
CLN3 Q13286 CLN3 lysosomal/endosomal transmembrane protein, battenin Transporter 1.3E-07 0.572 0.692 12 78
TYMP P19971 thymidine phosphorylase Enzyme 1.2E-04 0.495 0.769 23 73
BAP1 Q92560 BRCA1 associated protein 1 Enzyme 0.99 0.454 0.731 108 72
GLI3 P10071 GLI family zinc finger 3 1.00 0.436 0.846 31 67
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 110 65
KMT2A Q03164 lysine methyltransferase 2A 1.00 0.410 0.885 46 64
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 98 61
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
DES P17661 desmin 8.8E-03 0.460 0.846 36 56
SERPINA1 P01009 serpin family A member 1 Enzyme modulator 6.8E-08 0.410 0.923 59 47
WWOX Q9NZC7 WW domain containing oxidoreductase Enzyme 1.2E-15 0.453 0.808 39 45
PDHA1 P08559 pyruvate dehydrogenase E1 subunit alpha 1 0.99 0.581 0.538 23 45